文献

J-GLOBAL ID：201602262267544611   整理番号：16A1259931

分子プロファイリングはびまん性神経膠腫進行の生物学的に離散したサブセットおよび経路を明らかにする

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

著者 (58件)： Ceccarelli Michele (Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar) ,  Ceccarelli Michele (Department of Science and Technology, University of Sannio, Benevento 82100, Italy) ,  Barthel Floris P. (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Barthel Floris P. (Oncology Graduate School Amsterdam, Department of Pathology, VU University Medical Center, 1081 HV Amsterdam, the Netherlands) ,  Malta Tathiane M. (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Malta Tathiane M. (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Sabedot Thais S. (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Sabedot Thais S. (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Salama Sofie R. (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Murray Bradley A. (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Morozova Olena (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Newton Yulia (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Radenbaugh Amie (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Pagnotta Stefano M. (Department of Science and Technology, University of Sannio, Benevento 82100, Italy) ,  Pagnotta Stefano M. (BIOGEM Istituto di Ricerche Genetiche “G. Salvatore,” Campo Reale, 83031 Ariano Irpino, Italy) ,  Anjum Samreen (Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar) ,  Wang Jiguang (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Manyam Ganiraju (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Zoppoli Pietro (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Ling Shiyun (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rao Arjun A. (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Grifford Mia (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Cherniack Andrew D. (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Zhang Hailei (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Poisson Laila (Henry Ford Hospital, Detroit, MI 48202, USA) ,  Carlotti Carlos Gilberto (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Carlotti Carlos Gilberto (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Tirapelli Daniela Pretti da Cunha (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Tirapelli Daniela Pretti da Cunha (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Rao Arvind (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Mikkelsen Tom (Henry Ford Hospital, Detroit, MI 48202, USA) ,  Lau Ching C. (Texas Children’s Hospital, Houston, TX 77030, USA) ,  Lau Ching C. (Baylor College of Medicine, Houston, TX 77030, USA) ,  Yung W.K. Alfred (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rabadan Raul (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Huse Jason (Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  Brat Daniel J. (Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA) ,  Lehman Norman L. (Department of Pathology, The Ohio State University, Columbus, OH 43210, USA) ,  Barnholtz-Sloan Jill S. (Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA) ,  Zheng Siyuan (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hess Kenneth (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Rao Ganesh (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Meyerson Matthew (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Meyerson Matthew (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Beroukhim Rameen (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA) ,  Beroukhim Rameen (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Beroukhim Rameen (Department of Medicine, Harvard Medical School, Boston, MA 02215, USA) ,  Cooper Lee (Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA) ,  Akbani Rehan (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wrensch Margaret (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA) ,  Haussler David (UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA) ,  Aldape Kenneth D. (Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada) ,  Laird Peter W. (Van Andel Research Institute, Grand Rapids, MI 49503, USA) ,  Gutmann David H. (School of Medicine, Washington University, St. Louis, MO 63110, USA) ,  Noushmehr Houtan (Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Monte Alegre, Ribeirao Preto-SP CEP: 14049-900, Brazil) ,  Noushmehr Houtan (Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo 14049-900, Brazil) ,  Iavarone Antonio (Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA) ,  Verhaak Roel G.W. (Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 164  号： 3  ページ： 550-563  発行年： 2016年01月28日 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 成人びらん性神経膠腫の治療法の開発は,体細胞性神経膠腫による変化および準最適な疾患分類の不完全な知識によって妨げられている。著者らは,Cancer Genome Atlasからの1,122のびまん性神経膠腫のグレードII-III-IVに関連した遺伝子の完全なセットを定義し,そして疾患分類を改善するため,分子相関を特定するため,および低悪性度から高悪性度への進行に対する知見を提供するために,分子プロファイルを用いた。全ゲノムシーケンシングデータ解析は,TERTプロモーター遺伝子ではなくATRX遺伝子が増大したテロメア長と関連することを決定した。IDH遺伝子突然変異および1p/19q共欠失状態に基づく神経膠腫分類の最近の進歩は,臨床的に関連する分子サブセットを同定したDNAメチル化プロファイルの分析によって再現された。IDH変異神経膠腫のサブタイプは,DNA脱メチル化および不良な予後に関連した。IDH-野生型びまん性神経膠腫群は,線毛性星状細胞腫との分子類似性を示し,比較的良好な生存率を示した。関連疾患群の理解は,臨床結果の改善を助けるかもしれない。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.

シソーラス用語： ヒト ,  *神経膠腫 ,  コホート研究 ,  遺伝子 ,  *ゲノムワイド関連解析 ,  テロメア ,  ホメオスタシス ,  メチル化 ,  遺伝子発現 ,  病態生理 ,  イソクエン酸デヒドロゲナーゼ ,  ATRX遺伝子 ,  DNAメチル化 ,  IDH1遺伝子 ,  IDH2遺伝子 ,  TERT遺伝子 ,  遺伝子プロファイル ,  腫瘍関連遺伝子 ,  *遺伝的変異 ,  テロメアホメオスタシス ,  分子遺伝現象
準シソーラス用語： *遺伝子変異 ,  ゲノムコホート研究 ,  テロメア長管理 ,  びまん性神経膠腫

分類 (4件)： 基礎腫よう学一般  (GE02010R) ,  遺伝的変異  (EC01030Y) ,  遺伝子発現  (EC02040Q) ,  神経系の腫よう  (GN04000V)

タイトルに関連する用語 (5件)： 分子プロファイリング ,  神経膠腫 ,  生物学 ,  サブ ,  経路