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J-GLOBAL ID：201702210025768917   整理番号：17A1217249

民族横断的な全ゲノムスキャンは新規アルツハイマー病遺伝子座を同定する【Powered by NICT】

Transethnic genome-wide scan identifies novel Alzheimer’s disease loci

著者 (79件)： Jun Gyungah R. (Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA) ,  Jun Gyungah R. (Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA) ,  Chung Jaeyoon (Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA) ,  Mez Jesse (Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA) ,  Barber Robert (Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA) ,  Beecham Gary W. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA) ,  Bennett David A. (Department of Neurological Sciences and Rush Alzheimer’s Disease Center, Chicago, IL, USA) ,  Buxbaum Joseph D. (Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA) ,  Buxbaum Joseph D. (Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA) ,  Buxbaum Joseph D. (Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA) ,  Byrd Goldie S. (Department of Biology, North Carolina A&T State University, Greensboro, NC, USA) ,  Carrasquillo Minerva M. (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ,  Crane Paul K. (Department of Medicine, University of Washington, Seattle, WA, USA) ,  Cruchaga Carlos (Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA) ,  Cruchaga Carlos (Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA) ,  De Jager Philip (Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  De Jager Philip (Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA) ,  Ertekin-Taner Nilufer (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ,  Evans Denis (Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA) ,  Fallin M. Danielle (Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA) ,  Foroud Tatiana M. (Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA) ,  Friedland Robert P. (Department of Neurology, University of Louisville, Louisville, KY, USA) ,  Goate Alison M. (Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA) ,  Graff-Radford Neill R. (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ,  Hendrie Hugh (Department of Psychiatry, Indiana University, Indianapolis, IN, USA) ,  Hendrie Hugh (Regenstrief Institute, Inc, Indianapolis, IN, USA) ,  Hall Kathleen S. (Regenstrief Institute, Inc, Indianapolis, IN, USA) ,  Hall Kathleen S. (Department of Medicine, Indiana University, Indianapolis, IN, USA) ,  Hamilton-Nelson Kara L. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA) ,  Inzelberg Rivka (Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel) ,  Kamboh M. Ilyas (University of Pittsburgh Alzheimer’s Disease Research Center and Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA) ,  Kauwe John S.K. (Department of Biology, Brigham Young University, Provo, UT, USA) ,  Kukull Walter A. (Department of Epidemiology, University of Washington, Seattle, WA, USA) ,  Kukull Walter A. (National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA) ,  Kunkle Brian W. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA) ,  Kuwano Ryozo (Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan) ,  Larson Eric B. (Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA) ,  Larson Eric B. (Group Health, Group Health Research Institute, Seattle, WA, USA) ,  Logue Mark W. (Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA) ,  Logue Mark W. (Department of Neurological Sciences and Rush Alzheimer’s Disease Center, Chicago, IL, USA) ,  Logue Mark W. (National Center for PTSD, Behavioral Science Division, Boston VA Healthcare System, Boston, MA, USA) ,  Manly Jennifer J. (The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA) ,  Manly Jennifer J. (The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Martin Eden R. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA) ,  Montine Thomas J. (Department of Pathology, Stanford University, Stanford, CA, USA) ,  Mukherjee Shubhabrata (Department of Medicine, University of Washington, Seattle, WA, USA) ,  Naj Adam (Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA) ,  Reiman Eric M. (Arizona Alzheimer’s Consortium, Phoenix, AZ, USA) ,  Reiman Eric M. (Department of Psychiatry, University of Arizona, Phoenix, AZ, USA) ,  Reiman Eric M. (Banner Alzheimer’s Institute, Phoenix, AZ, USA) ,  Reiman Eric M. (Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA) ,  Reitz Christiane (The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Reitz Christiane (The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Reitz Christiane (The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Sherva Richard (Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA) ,  St. George-Hyslop Peter H. (Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada) ,  St. George-Hyslop Peter H. (Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK) ,  Thornton Timothy (Department of Medicine, University of Washington, Seattle, WA, USA) ,  Younkin Steven G. (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ,  Vardarajan Badri N. (The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA) ,  Vardarajan Badri N. (The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Vardarajan Badri N. (The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Wang Li-San (Arizona Alzheimer’s Consortium, Phoenix, AZ, USA) ,  Wendlund Jens R. (PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA) ,  Winslow Ashley R. (PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA) ,  Haines Jonathan (Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA) ,  Mayeux Richard (The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA) ,  Mayeux Richard (The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Mayeux Richard (The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Mayeux Richard (The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Mayeux Richard (The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA) ,  Pericak-Vance Margaret A. (The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA) ,  Schellenberg Gerard (Arizona Alzheimer’s Consortium, Phoenix, AZ, USA) ,  Lunetta Kathryn L. (Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA) ,  Farrer Lindsay A. (Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA) ,  Farrer Lindsay A. (Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA) ,  Farrer Lindsay A. (Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA) ,  Farrer Lindsay A. (Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA) ,  Farrer Lindsay A. (Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA)
資料名： Alzheimer’s & Dementia: Journal of the Alzheimer’s Association  (Alzheimer's & Dementia: Journal of the Alzheimer's Association)
巻： 13  号： 7  ページ： 727-738  発行年： 2017年 
JST資料番号： W3115A  ISSN： 1552-5260  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Alzheimer病(AD)に対する遺伝子座はヨーロッパ系の白人で同定されているが,他の個体群間のADの遺伝的構造はあまり理解されていない。Alzheimer病遺伝学コンソーシアムによって組み立てられたヨーロッパ系,アフリカ系アメリカ人,日本人およびイスラエルのアラブ人の白人を含むステージ1試料における遅発性ADの人種同一性障害のゲノムワイド関連研究(GWAS)を実施した。新規遺伝子座からステージ1から示唆する結果は,国際ゲノミクスアルツハイマープロジェクトGWASデータセットにまとめ結果を用いて追跡した。一塩基多型(SNP)に基づく試験(P<5 × 10~ 8)における有意なゲノムワイド(GWS)関係はPFDN1/HBEGF,USP6NL/ECHDC3,BZRAP1AS1のSNPsとNFIC SNP(アポリポ蛋白質E)APOEε4対立遺伝子の相互作用を同定した。も新規遺伝子座,TPGB(P=1.8 × 10~ 6)試料における遺伝子関連のGWS証拠(P<2.7 × 10~ 6)を得た。著者らの知見は,新しいAD感受性遺伝子座を同定するための人種同一性障害研究の価値を強調した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： ヨーロッパ ,  遺伝学 ,  *民族 ,  対立遺伝子 ,  イスラエル国 ,  ゲノムワイド関連解析 ,  一塩基多型 ,  *Alzheimer病 ,  *遺伝子 ,  アポE
準シソーラス用語： 人種 ,  日本人 ,  アフリカ系アメリカ人 ,  遺伝的構造 ,  白人 , 【Automatic Indexing@JST】

著者キーワード (4件)： 民族超越 ,  アルツハイマー病 ,  ゲノムワイド関連 ,  APOE相互作用

分類 (1件)： 遺伝的変異  (EC01030Y)

タイトルに関連する用語 (5件)： 民族 ,  ゲノムスキャン ,  アルツハイマー病 ,  遺伝子座 ,  同定