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J-GLOBAL ID：201702213651729807   整理番号：17A1443660

慢性肝臓疾患下での急性における急性腎損傷を予測するための素因,損傷,応答,臓器不全モデルの開発【Powered by NICT】

Development of predisposition, injury, response, organ failure model for predicting acute kidney injury in acute on chronic liver failure

著者 (58件)： Maiwall Rakhi (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Sarin Shiv Kumar (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Kumar Suman (Department of Clinical Hematology, Command Hospital [Eastern Command], Kolkata, India) ,  Jain Priyanka (Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Kumar Guresh (Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Bhadoria Ajeet Singh (Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Moreau Richard (UMR_S1149, Center for Research in Inflammation (CRI), Inserm and Paris Diderot University, Paris, France) ,  Moreau Richard (DHU Unity, Liver unit, Beaujon hospital, APHP, Clichy, France) ,  Kedarisetty Chandan Kumar (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Abbas Zaigham (Department of Gastroenterology, Ziauddin University Hospital, Karachi, Pakistan) ,  Amarapurkar Deepak (Department of Gastroenterology and Hepatology, Bombay Hospital and Medical Research, Mumbai, India) ,  Bhardwaj Ankit (Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Bihari Chhagan (Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Butt Amna Subhan (Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan) ,  Chan Albert (Department of Surgery, Division of Hepatobiliary and Pancreatic surgery, and Liver Transplantation, The University of Hong Kong, Hong Kong, China) ,  Chawla Yogesh Kumar (Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India) ,  Chowdhury Ashok (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Dhiman RadhaKrishan (Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India) ,  Dokmeci Abdul Kadir (Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey) ,  Ghazinyan Hasmik (Department of Hepatology, Nork Clinical Hospital of Infectious Diseases, Yerevan, Armenia) ,  Hamid Saeed Sadiq (Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan) ,  Kim Dong Joon (Center for Liver and Digestive Diseases, Hallym University Chuncheon Sacred Heart Hospital, Gangwon-Do, Korea) ,  Komolmit Piyawat (Department of Medicine, Division of Gastroenterology and Hepatology, Chulalongkorn University, Bangkok, Thailand) ,  Lau George K. (Department of Hepatology, The Institute of Translational Hepatology, Beijing 302 Hospital, Beijing, China) ,  LEE Guan Huei (Department of Medicine, National University Health System, Singapore, Singapore) ,  Lesmana Laurentius A. (Division of Hepatology, University of Indonesia, Jakarta, Indonesia) ,  Jamwal Kapil (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Mamun-Al-Mahtab (Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh) ,  Mathur Rajendra Prasad (Department of Nephrology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Nayak Suman Lata (Department of Nephrology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Ning Qin (Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Pamecha Viniyendra (Department of Hepatobiliary Surgery, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Alcantara-Payawal Diana (Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines) ,  Rastogi Archana (Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Rahman Salimur (Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh) ,  Rela Mohamed (Institute of Liver diseases and Transplantation, Global Health city, Chennai, India) ,  Saraswat Vivek A. (Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India) ,  Shah Samir (Department of Hepatology, Global Hospitals, Mumbai, India) ,  Shiha Gamal (Department of Internal Medicine, Egyptian Liver Research Institute and Hospital, Cairo, Egypt) ,  Sharma Barjesh Chander (Department of Gastroenterology, GB Pant Hospital, New Delhi, India) ,  Sharma Manoj Kumar (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Sharma Kapil (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Tan Soek Siam (Department of Hepatology Selayang Hospital, Selangor, Malaysia) ,  Chandel Shivendra Singh (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Vashishtha Chitranshu (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Wani Zeeshan A. (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) ,  Yuen Man-Fung (Department of Medicine, The University of Hong Kong, Hong Kong, China) ,  Yokosuka Osamu (Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Duseja Ajay (Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India) ,  Jafri Wasim (Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan) ,  Devarbhavi Harshad (Department of Gastroenterology, St.John’s Medical College and Hospital, Bangalore, India) ,  Eapen C. E. (Department of Gastroenterology and Hepatology, CMC, Vellore, India) ,  Goel Ashish (Department of Gastroenterology, Rome, NY, USA) ,  Sood Ajit (Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India) ,  Ji Jia (Department of Gastroenterology, Liver Research Center, Beijing, China) ,  Duan Z. (Department of Gastroenterology, Nanjing First Hospital, Nanjing, China) ,  Chen Y. (Department of Gastroenterology, East Brunswick, NJ, USA) ,  of the APASL ACLF Research Consortium (AARC) working party
資料名： Liver International  (Liver International)
巻： 37  号： 10  ページ： 1497-1507  発行年： 2017年 
JST資料番号： E0044B  ISSN： 1478-3223  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 背景と目的:慢性肝不全の急性における急性腎障害の予測因子に関するデータは限られている。慢性肝不全患者に対する急性の多中心性コホートにおける急性腎損傷を予測するためのPIROモデル(素因,損傷,応答,臓器不全)を開発した。APASL ACLF研究コンソーシアム(A ARC)からの2360例の患者と方法:データを解析した。多変量ロジスティック回帰モデル(PIROスコア)は,慢性肝不全患者(n=997)に対する急性のもう一つの前向き多施設コホートにおける検証された導出コホート(n=1363)から開発した。P成分の有意な【結果】因子は血清クレアチニン[(≧2 mg/dL)OR4.52年,95%CI(3.67 5.30)],ビリルビン[(<12 mg/dL,OR 1)対(12 30 mg/dL,OR 1.45, 95% 1.1 2.63)対(≧30 mg/dL,OR 2.6, 95% CI 1.3 5.2)],血清カリウム[(<3 mmol/LOR 1)対(3 4.9 mmol/L,OR 2.7, 95% CI 1.05 1.97)対(≧5 mmol/L,OR 4.34, 95% CI 1.67 11.3)]および血中尿素(OR 3.73, 95% CI 2.5 5.5)であった;I成分の腎毒性薬(OR 9.86, 95% CI 3.2 30.8)R成分,全身性炎症反応症候群(OR 2.14, 95% CI 1.4 3.3)O成分,循環不全(OR 3.5, 95% CI 2.2 5.5)。PIROスコアは誘導および確認コホートにおける0.95と0.96のC インデックスを伴う急性腎損傷を予測した。PIROスコアも導出と検証コホートの両方における死亡率(P<.001)と関連していた。【結論】PIROモデルは急性腎障害発症のリスクを慢性肝不全患者に対する急性同定し,層状化する。それは信頼性をもってこれらの患者の死亡率を予測する,慢性肝不全の急性患者における急性腎障害の予後的意義を強調した。Copyright 2017 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 信頼性 ,  *患者 ,  母集団 ,  死亡率 ,  腎毒性 ,  全身性炎症反応症候群
準シソーラス用語： 肝不全 ,  血清クレアチニン ,  スコア ,  ロジスティック回帰モデル ,  予測因子 ,  急性腎障害 ,  *臓器障害 ,  *急性腎損傷 ,  慢性肝疾患 , 【Automatic Indexing@JST】

著者キーワード (5件)： 急性腎損傷 ,  慢性肝臓疾患下での急性 ,  肝不全 ,  多臓器不全 ,  PIRO

分類 (2件)： 泌尿生殖器の臨床医学一般  (GM01030E) ,  泌尿生殖器の基礎医学  (GM01020T)

タイトルに関連する用語 (8件)： 慢性肝臓疾患 ,  急性腎損傷 ,  予測 ,  損傷 ,  応答 ,  臓器不全 ,  モデル ,  開発