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J-GLOBAL ID：201702226739985557   整理番号：17A1455808

低肺機能患者における糖尿病の多環芳香族炭化水素と中心性肥満リスク増加への曝露【Powered by NICT】

Exposure to polycyclic aromatic hydrocarbons and central obesity enhanced risk for diabetes among individuals with poor lung function

著者 (20件)： Hou Jian (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Hou Jian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Sun Huizhen (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Sun Huizhen (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Huang Xiji (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Huang Xiji (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Zhou Yun (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Zhou Yun (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Zhang Youjian (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Zhang Youjian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Yin Wenjun (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Yin Wenjun (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Xu Tian (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Xu Tian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Cheng Juan (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Cheng Juan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Chen Weihong (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Chen Weihong (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...) ,  Yuan Jing (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China) ,  Yuan Jing (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and ...)
資料名： Chemosphere  (Chemosphere)
巻： 185  ページ： 1136-1143  発行年： 2017年 
JST資料番号： E0843A  ISSN： 0045-6535  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： いくつかの研究は,肥満の間の関連または多環芳香族炭化水素(PAHs)への曝露と糖尿病のリスクを示した。本研究では,糖尿病に対する肥満と尿モノヒドロキシPAHs(OH PAHs)の相互作用を研究することを目的とした。個人(n=2716)は,武漢珠海コホート研究のベースライン調査から採取した。彼らは,身体検査,肺機能,生化学的指標と尿OH-PAHsレベルの測定を完了した。糖尿病に対する肥満と尿ΣOH/PAHsレベルの添加効果は,相互作用による相互作用(RERI)と寄与割合(AP)による相対過剰リスクを計算することにより評価した。いくつかの尿OH-PAHsを積極的に中心性肥満または正常体重(全てに対しp<0.05)患者における糖尿病と関連していた。低肺機能患者の中で,尿ΣOH/PAHs及び胴囲(WC, RERI: 0.866, 95% CI: 0.431, 2.164, p=0.192)または胴囲-身長比(WHtR, RERI: 1.091, 95% CI: 0.124, 2.305, p=0.078)間のRERIが観察された。尿ΣOH/PAHsとWCまたはWHtR間の相互作用に起因するAPは0.383(95% CI: 0.07,0.80, p=0.086)または0.465(95% CI: 0.019,0.912, p=0.04)であった。結果は,中心性肥満は低肺機能患者における糖尿病に対する背景のPAHへの曝露の効果を強化する可能性があることを示した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *糖尿病 ,  生化学 ,  相互作用 ,  身長 ,  基準線 ,  *芳香族縮合炭化水素 ,  添加物効果 ,  *患者 ,  理学的検査 ,  体重 ,  コホート研究 ,  *肥満
準シソーラス用語： ウエスト周囲径 ,  *肺機能 ,  *換気困難 , 【Automatic Indexing@JST】

著者キーワード (4件)： 多環芳香族炭化水素 ,  肥満 ,  肺機能 ,  糖尿病

分類 (1件)： その他の汚染原因物質  (SB05040W)

タイトルに関連する用語 (7件)： 低肺機能 ,  患者 ,  糖尿病 ,  多環芳香族炭化水素 ,  中心性肥満 ,  リスク ,  曝露