文献

J-GLOBAL ID：201702231990541714   整理番号：17A0504317

効果的な癌治療に必要な許容範囲内の薬物濃度を維持するため経口活性カルボプラチン/デオキシコール酸複合体を使用したメトロノーム化学療法

Metronomic chemotherapy using orally active carboplatin/deoxycholate complex to maintain drug concentration within a tolerable range for effective cancer management

著者 (12件)： Mahmud Foyez (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea) ,  Chung Seung Woo (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea) ,  Alam Farzana (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea) ,  Choi Jeong Uk (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea) ,  Kim Seong Who (Department of Biochemistry and Molecular Biology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 138-736, South Korea) ,  Kim In-San (Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kim Sang Yoon (Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kim Sang Yoon (Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 138-736, South Korea) ,  Lee Dong Soo (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea) ,  Lee Dong Soo (Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, South Korea) ,  Byun Youngro (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea) ,  Byun Youngro (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea)
資料名： Journal of Controlled Release  (Journal of Controlled Release)
巻： 249  ページ： 42-52  発行年： 2017年03月10日 
JST資料番号： C0308D  ISSN： 0168-3659  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： メトロノーム化学療法は良好な毒性プロファイルに変換され,腫瘍...

シソーラス用語： 病態モデル ,...
準シソーラス用語： *メトロノーム化学療法

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著者キーワード (5件)： Carboplatin ,  Oral anticancer ,  Metronomic dose ,  Oral drug delivery ,  Bile acids

分類 (1件)： 腫ようの実験的治療  (GE02040Y)

物質索引 (1件)： デオキシコール酸

引用文献 (48件)：

• N. Andre, M. Carre, E. Pasquier, Metronomics: towards personalized chemotherapy? Nat. Rev. Clin. Oncol. 11 (2014) 413-431.
• E. Pasquier, M. Kavallaris, N. Andre, Metronomic chemotherapy: new rationale for new directions, Nat. Rev. Clin. Oncol. 7 (2010) 455-465.
• D. Hanahan, G. Bergers, E. Bergsland, Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice, J. Clin. Invest. 105 (2000) 1045-1047.
• T. Browder, C.E. Butterfield, B.M. Kraling, B. Shi, B. Marshall, M.S. O'Reilly, J. Folkman, Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer, Cancer Res. 60 (2000) 1878-1886.
• G. Klement, S. Baruchel, J. Rak, S. Man, K. Clark, DJ. Hicklin, P. Bohlen, R.S. Kerbel, Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity, J. Clin. Invest. 105 (2000) R15-R24.

タイトルに関連する用語 (8件)： 癌治療 ,  許容範囲 ,  薬物濃度 ,  活性 ,  カルボプラチン ,  デオキシコール酸 ,  複合体 ,  メトロノーム化学療法