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J-GLOBAL ID：201702233914730946   整理番号：17A1169367

グラム陰性細菌感染創傷のための細菌セルロースと小分子で修飾した金ナノ粒子の複合材料【Powered by NICT】

Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds

著者 (16件)： Li Ying (National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China) ,  Li Ying (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Tian Yue (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Tian Yue (Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, 100050, China) ,  Zheng Wenshu (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Feng Yan (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Huang Rong (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Shao Jingxin (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Tang Rongbing (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Wang Peng (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Jia Yuexiao (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Zhang Jiangjiang (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Zheng Wenfu (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Yang Guang (National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China) ,  Jiang Xingyu (CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China) ,  Jiang Xingyu (University of Chinese Academy of Sciences, Beijing, 100190, China)
資料名： Small  (Small)
巻： 13  号： 27  ページ： ROMBUNNO.201700130  発行年： 2017年 
JST資料番号： W2348A  ISSN： 1613-6810  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 特に多剤耐性細菌感染症,細菌感染症は,創傷治癒の分野でますます深刻な問題である。4,6-ジアミノ-2-ピリミジンチオール(DAPT)修飾金ナノ粒子(Au DAPT NPs)により修飾されたバクテリアセルロース(BC)は,細菌感染創傷の治療のためのドレッシング(BC Au DAPTナノ複合材料)として提示した。BC Au DAPTナノ複合材料はグラム陰性菌に対して最もの抗生物質(セファゾリン/スルファメトキサゾール)よりも良好な有効性(最小発育阻止濃度で測定した)を持ち,吸水能力,機械的歪,および生体適合性を含む優れた物理化学的性質を維持した。ラットに対するEscherichia coliあるいはPseudomonas aeruginosaが感染した全層皮膚創傷,BC Au DAPTナノ複合材料は細菌増殖を阻害し,創傷治癒を促進する。BC Au DAPTナノ複合材料系はスーパーバグ感染創傷を治療するための有望なプラットフォームである。Copyright 2017 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *ナノ粒子 ,  生体適合性 ,  細菌感染症 ,  抗生物質 ,  *金 ,  創傷治癒 ,  *細菌感染 ,  最小発育阻止濃度 ,  大腸菌 ,  ナノ複合材料 ,  *感染 ,  多剤耐性 ,  緑膿菌 ,  グラム陰性菌
準シソーラス用語： *金ナノ粒子 , 【Automatic Indexing@JST】

著者キーワード (4件)： 抗菌 ,  Au DAPTナノ粒子 ,  細菌セルロース ,  BC Au DAPTナノ複合材料

分類 (1件)： 医用素材  (GA05040H)

タイトルに関連する用語 (8件)： グラム陰性細菌 ,  感染 ,  創傷 ,  細菌セルロース ,  小分子 ,  修飾 ,  金ナノ粒子 ,  複合材料