文献

J-GLOBAL ID：201702236252928421   整理番号：17A0153073

人工間葉系幹細胞からの抗癌タンパク質MDA-7の分泌制御

Controlled Secretion of the Anticancer Protein MDA-7 from Engineered Mesenchymal Stem Cells

著者 (10件)： Sagara Atsunobu (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Karasawa Takeshi (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Igarashi Katsuhide (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Otsuka Maky (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Sugiura Rei (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Kodama Akihiro (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Yamashita Mutsumi (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Narita Minoru (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Narita Minoru (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences) ,  Kato Yoshinori (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences)
資料名： Biological and Pharmaceutical Bulletin  (Biological and Pharmaceutical Bulletin)
巻： 40  号： 1  ページ： 113-117(J-STAGE)  発行年： 2017年 
JST資料番号： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 間葉系幹細胞(MSC)は標的癌療法のためのサイトカインの“生...

シソーラス用語： *間葉系幹細胞 ,...
準シソーラス用語： HUVEC ,...

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著者キーワード (10件)： controlled secretion ,  melanoma differentiation-associated gene-7 ,  mesenchymal stem cell ,  Tet-On system ,  in vitro ,  controlled secretion ,  melanoma differentiation-associated gene-7 ,  mesenchymal stem cell ,  Tet-On system ,  in vitro

分類 (1件)： 基礎腫よう学一般  (GE02010R)

物質索引 (1件)： ドキシサイクリン

引用文献 (21件)：

• 1) Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene, 11, 2477-2486 (1995).
• 2) Ekmekcioglu S, Ellerhorst J, Mhashilkar AM, Sahin AA, Read CM, Prieto VG, Chada S, Grimm EA. Down-regulated melanoma differentiation associated gene (MDA-7) expression in human melanomas. Int. J. Cancer, 94, 54-59 (2001).
• 3) Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proc. Natl. Acad. Sci. U.S.A., 108, 8785-8790 (2011).
• 4) Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, Mhashilkar A, Parker K, Vukelja S, Richards D, Hood J, Coffee K, Nemunaitis J. Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a Phase I study. Mol. Ther., 11, 149-159 (2005).
• 5) Eager R, Harle L, Nemunaitis J. Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. Expert Opin. Biol. Ther., 8, 1633-1643 (2008).

タイトルに関連する用語 (5件)： 人工 ,  間葉系幹細胞 ,  癌タンパク質 ,  MDA ,  分泌