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J-GLOBAL ID：201702238163032332   整理番号：17A1466756

超安定化による天然様HIV-1エンベロープ三量体の免疫原性の改善【Powered by NICT】

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

著者 (31件)： Torrents de la Pena Alba (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Julien Jean-Philippe (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  de Taeye Steven W. (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Garces Fernando (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Guttman Miklos (Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA) ,  Ozorowski Gabriel (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Pritchard Laura K. (Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK) ,  Behrens Anna-Janina (Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK) ,  Go Eden P. (Department of Chemistry, University of Kansas, Lawrence, KS 66047, USA) ,  Burger Judith A. (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Schermer Edith E. (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Sliepen Kwinten (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Ketas Thomas J. (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA) ,  Pugach Pavel (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA) ,  Yasmeen Anila (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA) ,  Cottrell Christopher A. (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Torres Jonathan L. (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Vavourakis Charlotte D. (Microbial Systems Ecology, Department of Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam 1098 XH, the Netherlands) ,  van Gils Marit J. (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  LaBranche Celia (Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA) ,  Montefiori David C. (Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA) ,  Desaire Heather (Department of Chemistry, University of Kansas, Lawrence, KS 66047, USA) ,  Crispin Max (Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK) ,  Klasse Per Johan (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA) ,  Lee Kelly K. (Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA) ,  Moore John P. (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA) ,  Ward Andrew B. (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Wilson Ian A. (Department of Integrative Structural and Computational Biology, Scripps CHAVI-ID, IAVI Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Wilson Ian A. (The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Sanders Rogier W. (Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands) ,  Sanders Rogier W. (Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA)
資料名： Cell Reports  (Cell Reports)
巻： 20  号： 8  ページ： 1805-1817  発行年： 2017年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： HIV-1エンベロープ糖蛋白質(Env)三量体の天然様組換体の産生は複合体の天然柔軟性と不安定性を克服する必要がある。人工BG505SOSIP.664三量体は天然Envの構造と抗原性を模倣した。BG505と他の遺伝子型のSOSIP三量体の糖蛋白質間の新ジスルフィド結合(gp)120とgp41サブユニットの導入は,それらの安定性と抗原性を改善し,それらの立体配座柔軟性を低下させ,非配位立体配座におけるそれらの維持を助けるかを記述した。得られた次世代SOSIP。v5三量体はウサギにおける強い自己ティアー-2中和抗体(NAb)応答を誘導する。さらに,BG505SOSIP。v6三量体はプロトタイプBG505SOSIP.664により誘発されなかったティアー-2ウイルスのサブセットに対して弱い異種NAb応答を誘導した。これら安定化法は,NAb(bNAbs)を誘導することを目的とした多価ワクチンの成分としての複数の遺伝子型から三量体に適用することができる。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *免疫原性 ,  柔軟性 ,  ジスルフィド結合 ,  立体配座 ,  不安定性 ,  *HIV1 ,  サブユニット ,  中和抗体 ,  遺伝子型 ,  *三量体 ,  ワクチン ,  複合体 ,  プロトタイプ ,  糖タンパク質
準シソーラス用語： エンベロープ糖蛋白質 , 【Automatic Indexing@JST】

分類 (3件)： 酵素一般  (EB09010D) ,  ウイルスの生化学  (EG04030F) ,  分子構造  (EB03020Y)

タイトルに関連する用語 (5件)： 安定化 ,  HIV-1 ,  エンベロープ ,  三量体 ,  免疫原性