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J-GLOBAL ID：201702241809657047   整理番号：17A1961887

ゲノム-核ラミナ相互作用心臓幹細胞系統制限を調節する【Powered by NICT】

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction

著者 (19件)： Poleshko Andrey (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Shah Parisha P. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Gupta Mudit (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Babu Apoorva (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Morley Michael P. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Manderfield Lauren J. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Ifkovits Jamie L. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Calderon Damelys (Department of Cell, Developmental, and Regenerative Biology, Mindich Child Health and Development Institute, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Aghajanian Haig (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Sierra-Pagan Javier E. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Sun Zheng (Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Wang Qiaohong (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Li Li (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Dubois Nicole C. (Department of Cell, Developmental, and Regenerative Biology, Mindich Child Health and Development Institute, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Morrisey Edward E. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Lazar Mitchell A. (Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Smith Cheryl L. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Epstein Jonathan A. (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Jain Rajan (Departments of Medicine and Cell and Developmental Biology, Institute for Regenerative Medicine, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 171  号： 3  ページ： 573-587.e14  発行年： 2017年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 前駆細胞は系統特異的遺伝子の協調的発現と複雑なクロマチン構成の修飾を介して特殊化した細胞型に分化する。ヒストンデアセチラーゼ(HDAC3)は,心臓前駆体リネージ制限中の核ラミナでのヘテロクロマチンを組織化することを示した。心筋細胞の仕様である周縁ヘテロクロマチンの再編成と関連し,デアセチラーゼ活性,核ラミナに系統関連遺伝子を含むHdac3テザー周縁ヘテロクロマチンとは無関係であった。心臓前駆細胞におけるHdac3の欠失は核周辺のゲノム領域を放出し,心筋細胞への早発性心臓遺伝子発現と分化に導く対照的に,核周辺にHdac3を制限する前駆細胞はHdac3を欠くにおける筋形成をレスキューする。著者らの結果は,系統特異的因子による活性化のためのゲノム領域の利用可能性は,動的なクロマチン核ラミナ相互作用を介して部分的に調節され,分化シグナルに応答する前駆細胞の能力は核周辺から離れた応答遺伝子座の協調運動に依存するかもしれないことを示唆した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 遺伝子発現 ,  ヘテロクロマチン ,  筋形成 ,  心筋細胞 ,  ヒストンデアセチラーゼ ,  *心臓 ,  遺伝子 ,  前駆体 ,  クロマチン ,  *ゲノム ,  *相互作用
準シソーラス用語： デアセチラーゼ ,  細胞型 ,  前駆細胞 ,  *核ラミナ , 【Automatic Indexing@JST】

著者キーワード (5件)： 心臓特異化 ,  核ラミナ ,  ゲノム構成 ,  系統制限 ,  細胞能力

分類 (2件)： 生物学的機能  (EB03040U) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (7件)： ゲノム ,  核ラミナ ,  相互作用 ,  心臓幹細胞 ,  系統 ,  制限 ,  調節