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J-GLOBAL ID：201702243866162230   整理番号：17A1551418

カスタマイズされたコラーゲン足場を介した表皮成長因子受容体阻害剤の送達はウサギモデルにおける半月板欠損再生を促進する【Powered by NICT】

Delivery of epidermal growth factor receptor inhibitor via a customized collagen scaffold promotes meniscal defect regeneration in a rabbit model

著者 (46件)： Pan Zongyou (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Pan Zongyou (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Pan Zongyou (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Pan Zongyou (Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, China) ,  Wu Yan (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Wu Yan (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Wu Yan (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Zhang Xiaolei (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Zhang Xiaolei (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Zhang Xiaolei (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Zhang Xiaolei (Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, China) ,  Zhang Xiaolei (China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China) ,  Fu Qianbao (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Fu Qianbao (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Fu Qianbao (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Li Jun (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Li Jun (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Li Jun (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Yang Yang (Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, China) ,  Yu Dongsheng (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Yu Dongsheng (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Yu Dongsheng (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Xu Yuzi (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Xu Yuzi (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Xu Yuzi (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Lu Xiaolang (Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, China) ,  Sun Heng (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Sun Heng (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Sun Heng (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Zhang Xianzhu (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Zhang Xianzhu (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Zhang Xianzhu (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Heng Boon Chin (Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region) ,  Bunpetch Varitsara (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Bunpetch Varitsara (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Bunpetch Varitsara (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Zhang Shufang (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Zhang Shufang (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Zhang Shufang (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Zhang Shufang (China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China) ,  Ouyang Hongwei (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, School of Medicine, Zhejiang University, China) ,  Ouyang Hongwei (Zhejiang Key Laboratory for Tissue Engineering and Repair Technology, School of Medicine, Zhejiang University, Zhejiang 310009, China) ,  Ouyang Hongwei (Department of Sports Medicine, School of Medicine, Zhejiang University, Zhejiang 310000, China) ,  Ouyang Hongwei (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China) ,  Ouyang Hongwei (Department of Orthopaedics, The Second Affiliated Hospital, Wenzhou Medical University, China) ,  Ouyang Hongwei (China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China)
資料名： Acta Biomaterialia  (Acta Biomaterialia)
巻： 62  ページ： 210-221  発行年： 2017年 
JST資料番号： W3136A  ISSN： 1742-7061  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 半月板損傷は最も一般的な膝関節損傷の一つ,今日まで臨床診療における難治性課題として残っている。ヒトおよびマウス半月板損傷の両方における異常な表皮成長因子受容体(EGFR)活性化レベルは,を促した誘導軟骨特異的EGFR欠損マウスモデルを用いてEGFRの機能的役割を調べた。はマウスにおける条件付きEGFR欠失はメニスカス内の増加した部分半月板切除誘導E CM産生,低分子EGFR阻害剤の利用,ゲフィチニブ,ブロックEGFR活性に匹敵することをもたらしたことを示した。ここでは,注入したカスタマイズされたコラーゲン足場とゲフィチニブの関節内送達を組み合わせた失われた半月板組織の代わりに,半月板再生を促進し,ウサギ半月板切除モデルにおける変形性関節症(OA)の進行を防止した。本研究の主な新規性は,半月板損傷治療における低分子EGFR阻害剤の新しい応用の発見である。本研究では,ロバストな機械的強度を提供し,効果的に半月板再生を促進するためのカスタマイズされたコラーゲン足場を用いることの重要性を強調した。要約すると,著者らの研究は,カスタマイズされた,多層コラーゲン足場の移植と共にゲフィチニブの関節内デリバリーは半月板再生を促進するのみならず,ウサギモデルにおける変性から関節軟骨を保護することを見出した。これらの結果は,半月板組織工学研究と臨床のための貴重な洞察を提供した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *EGF受容体 ,  機械的強度 ,  変形性関節症 ,  *カスタム化 ,  治療法 ,  関節軟骨 ,  *コラーゲン ,  メニスカス ,  *半月板 ,  生体組織工学 ,  *モデル ,  ヒト
準シソーラス用語： 半月板切除術 ,  半月板損傷 ,  *阻害剤 , 【Automatic Indexing@JST】

著者キーワード (4件)： ゲフィチニブ ,  コラーゲン足場 ,  メニスカス ,  EGFR

分類 (2件)： 骨格系  (EJ10030R) ,  運動器系の基礎医学  (GG01020B)

タイトルに関連する用語 (10件)： カスタマイズ ,  コラーゲン ,  足場 ,  表皮成長因子受容体 ,  阻害剤 ,  送達 ,  ウサギモデル ,  半月板 ,  欠損 ,  促進