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J-GLOBAL ID：201702245551422132   整理番号：17A1491965

ヒストンCrotonylationと精子形成を調節するクロモドメイン蛋白質CDYLはクロトニルCoAヒドラターゼとして作用する【Powered by NICT】

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis

著者 (25件)： Liu Shumeng (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Liu Shumeng (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China) ,  Yu Huajing (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Liu Yongqing (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Liu Xinhua (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China) ,  Liu Xinhua (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China) ,  Zhang Yu (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Bu Chen (Jingjie PTM BioLab (Hangzhou), Co. Ltd., Hangzhou 310018, China) ,  Yuan Shuai (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Chen Zhe (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Xie Guojia (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Li Wanjin (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Xu Bosen (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Yang Jianguo (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  He Lin (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Jin Tong (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Xiong Yundong (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Sun Luyang (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Liu Xiaohui (School of Life Sciences, Tsinghua University, Beijing 100084, China) ,  Han Chunsheng (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China) ,  Cheng Zhongyi (Jingjie PTM BioLab (Hangzhou), Co. Ltd., Hangzhou 310018, China) ,  Liang Jing (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Shang Yongfeng (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China) ,  Shang Yongfeng (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China) ,  Shang Yongfeng (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)
資料名： Molecular Cell  (Molecular Cell)
巻： 67  号： 5  ページ： 853-866.e5  発行年： 2017年 
JST資料番号： W1167A  ISSN： 1097-2765  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： リジンcrotonylation(Kcr)は,哺乳類細胞における活発な転写と関連していることを新たに同定されたヒストン修飾である。クロモドメインY様転写コレプレッサーCDYLはクロトニル-CoAを変換β-ヒドロキシブイチリルCoAにクロトニル-CoAヒドラターゼとして作用することによりヒストンKcrを負に調節することを報告する。CDYLによるヒストンKcrの負の調節はその転写抑制活性に本質的に結合および円形精子細胞とゲノムワイドヒストン置換伸長精子細胞における性染色体連鎖遺伝子の再活性化における機能的に実行することを示した。CdylトランスジェニックマウスはヒストンKcrの調節異常と減少した精巣上体精子数と精子細胞運動性と雄性稔性の減少を明らかにした。著者らの研究は,ヒストンKcrの調節における生化学的経路を明らかにし,精子形成におけるCDYL調節されたヒストンKcrを暗示し,雄の生殖の生理学とAZFc(無精子症因子c)-欠失不妊症の男性の精子形成不全の機構の理解に追加した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 細胞運動 ,  遺伝子 ,  不妊症 ,  精巣上体 ,  *ヒストン ,  トランスジェニックマウス ,  *精子形成 ,  男性 ,  *精子 ,  *ヒドロリアーゼ
準シソーラス用語： 無精子症 ,  精子数 ,  精子細胞 ,  ヒストン修飾 ,  *クロモドメイン , 【Automatic Indexing@JST】

著者キーワード (6件)： CDYL ,  ヒストンcrotonylation ,  クロトニル-CoAヒドラターゼ ,  精子形成 ,  遺伝子転写 ,  ヒストン置換

分類 (1件)： 遺伝子発現  (EC02040Q)

タイトルに関連する用語 (7件)： ヒストン ,  精子形成 ,  調節 ,  クロモドメイン ,  蛋白質 ,  クロトニルCoA ,  ヒドラターゼ