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J-GLOBAL ID：201702246786881371   整理番号：17A1217138

CAMKIIγを促進するT細胞リンパ腫によるc-Myc蛋白質の安定化【Powered by NICT】

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

著者 (28件)： Gu Ying (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Zhang Jiawei (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Ma Xiaoxiao (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Ma Xiaoxiao (Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Kim Byung-wook (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Kim Byung-wook (Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Wang Hailong (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Li Jinfan (Department of Pathology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) ,  Pan Yi (Department of Pathology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China) ,  Xu Yang (Department of Hematology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) ,  Xu Yang (Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) ,  Ding Lili (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Yang Lu (The Integrative Genomics Core, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Guo Chao (The Integrative Genomics Core, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Wu Xiwei (The Integrative Genomics Core, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Wu Jun (Division of Comparative Medicine, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Wu Kirk (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Gan Xiaoxian (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Li Gang (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Li Ling (Division of Hematopoietic Stem Cell & Leukemia Research, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Forman Stephen J. (Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Forman Stephen J. (Department of Hematology & Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Chan Wing-Chung (Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Chan Wing-Chung (Department of Pathology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Xu Rongzhen (Department of Hematology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) ,  Xu Rongzhen (Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) ,  Huang Wendong (Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA) ,  Huang Wendong (Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA)
資料名： Cancer Cell  (Cancer Cell)
巻： 32  号： 1  ページ： 115-128.e7  発行年： 2017年 
JST資料番号： W1844A  ISSN： 1535-6108  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 高c-Myc蛋白質発現はいくつかの癌におけるMYC増幅に沿って観察されるが,ほとんどの場合蛋白質過剰発現は遺伝子増幅,例えば,T細胞リンパ腫(TCL)のない状態で起こった。,Ca~2+/カルモジュリン依存性蛋白質キナーゼIIγ(CAMKIIγ)はセリン62(S62)で直接りん酸化によるc-Myc蛋白質を安定化することを示した。CAMKIIγは腫瘍維持に必須であることが示された。特異的阻害剤CAMKIIγの阻害はc-Mycと減少した腫瘍負担を不安定化した。重要なことに,患者TCL試験片における高CAMKIIγレベルは増加したc-MycとpS62C Mycレベルと相関していた。CAMKIIγ:c-Myc軸はTCLの発生と維持に大きく影響しTCLのための潜在的な治療標的である。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *タンパク質 ,  タンパク質キナーゼ ,  *T細胞リンパ腫 ,  リン酸化 ,  患者 ,  遺伝子増幅 ,  腫瘍 ,  カルモジュリン
準シソーラス用語： 治療標的 ,  *Myc蛋白質 ,  不安定化 ,  阻害剤 ,  過剰発現 ,  蛋白質発現 ,  *癌原遺伝子蛋白質c-myc , 【Automatic Indexing@JST】

著者キーワード (5件)： c-MYC ,  T細胞リンパ腫 ,  CAMKIIγ ,  phosphorylation ,  c-Myc安定化

分類 (4件)： 遺伝子発現  (EC02040Q) ,  細胞構成体の機能  (EF03060C) ,  細胞生理一般  (EF02010S) ,  抗腫よう薬の基礎研究  (GW16010A)

タイトルに関連する用語 (5件)： CaMKII ,  促進 ,  T細胞リンパ腫 ,  c-myc蛋白質 ,  安定化