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J-GLOBAL ID：201702252035217645   整理番号：17A1491910

組織特異的機能とヒト疾患におけるMACF1,多様性【Powered by NICT】

MACF1, versatility in tissue-specific function and in human disease

著者 (35件)： Hu Lifang (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Hu Lifang (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Hu Lifang (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Xiao Yunyun (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Xiao Yunyun (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Xiao Yunyun (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Xiong Zhipeng (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Xiong Zhipeng (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Xiong Zhipeng (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Zhao Fan (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Zhao Fan (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Zhao Fan (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Yin Chong (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Yin Chong (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Yin Chong (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Zhang Yan (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Zhang Yan (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Zhang Yan (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Su Peihong (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Su Peihong (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Su Peihong (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Li Dijie (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Li Dijie (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Li Dijie (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Chen Zhihao (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Chen Zhihao (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Chen Zhihao (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Ma Xiaoli (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Ma Xiaoli (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Ma Xiaoli (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Zhang Ge (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China) ,  Zhang Ge (Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China) ,  Qian Airong (Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China) ,  Qian Airong (Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 518057, China) ,  Qian Airong (NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China)
資料名： Seminars in Cell & Developmental Biology  (Seminars in Cell & Developmental Biology)
巻： 69  ページ： 3-8  発行年： 2017年 
JST資料番号： T0944B  ISSN： 1084-9521  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Spectraplakinは進化的に保存された巨大な蛋白質ファミリーであり,多くの細胞骨格関連過程で重要な役割を果たしている。微小管アクチン橋かけ因子1(MACF1)は,複数のイソ型を持つ最も多才スペクトラプラキンの一つである。広く発現する哺乳類のスペクトラプラキンとして,MACF1は多くの組織の正常な機能の維持に重要である。ノックアウトマウスモデルを用いた機能喪失研究は胚発生,皮膚完全性維持,神経発生,骨形成,および結腸傍細胞透過性におけるMACF1の重要な役割を明らかにした。ヒトMACF1遺伝子の変異は新規ミオパチー遺伝的疾患を引き起こす。さらに,MACF1の異常発現は統合失調症,パーキンソン病,癌および骨粗鬆症と関連している。これは生理学及び病理学におけるMACF1の重要な役割を示した。ここでは,特異的な組織とヒト疾患におけるMACF1の役割の研究の進歩をレビューし,将来の研究のためのMACF1の展望を提供した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 細胞骨格 ,  *ヒト ,  哺乳類 ,  統合失調症 ,  微小管 ,  病理学 ,  胚発生 ,  Parkinson病 ,  アクチン ,  筋疾患 ,  骨粗鬆症 ,  遺伝
準シソーラス用語： 神経発生 ,  アイソフォーム ,  *ヒトの病気 , 【Automatic Indexing@JST】

著者キーワード (5件)： MACF1 ,  Spectraplakin ,  ノックアウトマウスモデル ,  組織特異的機能 ,  ヒト疾患

分類 (5件)： 遺伝子発現  (EC02040Q) ,  婦人科・産科の基礎医学  (GS01020L) ,  動物の代謝と栄養一般  (EJ02031R) ,  細胞生理一般  (EF02010S) ,  酵素一般  (EB09010D)

タイトルに関連する用語 (3件)： 組織 ,  ヒト疾患 ,  多様性