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J-GLOBAL ID：201702252699507773   整理番号：17A1559277

びまん性大細胞型B細胞リンパ腫の遺伝的および機能的ドライバ【Powered by NICT】

Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma

著者 (62件)： Reddy Anupama (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Reddy Anupama (Department of Medicine, Duke University Medical Center, Durham, NC, USA) ,  Zhang Jenny (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Zhang Jenny (Department of Medicine, Duke University Medical Center, Durham, NC, USA) ,  Davis Nicholas S. (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Moffitt Andrea B. (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Love Cassandra L. (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Waldrop Alexander (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Leppa Sirpa (Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland) ,  Pasanen Annika (Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland) ,  Meriranta Leo (Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland) ,  Karjalainen-Lindsberg Marja-Liisa (Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland) ,  Norgaard Peter (Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark) ,  Pedersen Mette (Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark) ,  Gang Anne O. (Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark) ,  Hogdall Estrid (Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark) ,  Heavican Tayla B. (Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA) ,  Lone Waseem (Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA) ,  Iqbal Javeed (Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA) ,  Qin Qiu (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Li Guojie (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Kim So Young (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Healy Jane (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Richards Kristy L. (Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA) ,  Fedoriw Yuri (Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA) ,  Bernal-Mizrachi Leon (Winship Cancer Institute, Emory University, Atlanta, GA, USA) ,  Koff Jean L. (Winship Cancer Institute, Emory University, Atlanta, GA, USA) ,  Staton Ashley D. (Winship Cancer Institute, Emory University, Atlanta, GA, USA) ,  Flowers Christopher R. (Winship Cancer Institute, Emory University, Atlanta, GA, USA) ,  Paltiel Ora (Hadassah-Hebrew University Medical Center, Jerusalem, Israel) ,  Goldschmidt Neta (Hadassah-Hebrew University Medical Center, Jerusalem, Israel) ,  Calaminici Maria (Barts Cancer Institute of Queen Mary University of London, London, UK) ,  Clear Andrew (Barts Cancer Institute of Queen Mary University of London, London, UK) ,  Gribben John (Barts Cancer Institute of Queen Mary University of London, London, UK) ,  Nguyen Evelyn (Pathology, Indiana University, Indianapolis, IN, USA) ,  Czader Magdalena B. (Pathology, Indiana University, Indianapolis, IN, USA) ,  Ondrejka Sarah L. (Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA) ,  Collie Angela (Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA) ,  Hsi Eric D. (Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA) ,  Tse Eric (Queen Mary Hospital, University of Hong Kong, Hong Kong) ,  Au-Yeung Rex K.H. (Queen Mary Hospital, University of Hong Kong, Hong Kong) ,  Kwong Yok-Lam (Queen Mary Hospital, University of Hong Kong, Hong Kong) ,  Srivastava Gopesh (Queen Mary Hospital, University of Hong Kong, Hong Kong) ,  Choi William W.L. (Queen Mary Hospital, University of Hong Kong, Hong Kong) ,  Evens Andrew M. (Tufts University Medical Center, Boston, MA, USA) ,  Pilichowska Monika (Tufts University Medical Center, Boston, MA, USA) ,  Sengar Manju (Tata Memorial Center, Mumbai, India) ,  Reddy Nishitha (Vanderbilt University Medical Center, Nashville, TN, USA) ,  Li Shaoying (MD Anderson Cancer Center, Houston, TX, USA) ,  Chadburn Amy (Columbia-Presbyterian Hospital, New York, NY, USA) ,  Gordon Leo I. (Northwestern University Medical School, Chicago, IL, USA) ,  Jaffe Elaine S. (National Cancer Institute, Bethesda, MD, USA) ,  Levy Shawn (Hudson Alpha Institute for Biotechnology, Huntsville, AL, USA) ,  Rempel Rachel (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Tzeng Tiffany (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Happ Lanie E. (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Dave Tushar (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Rajagopalan Deepthi (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Datta Jyotishka (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Dunson David B. (Department of Statistical Science, Duke University, Durham, NC, USA) ,  Dave Sandeep S. (Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA) ,  Dave Sandeep S. (Department of Medicine, Duke University Medical Center, Durham, NC, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 171  号： 2  ページ： 481-494.e15  発行年： 2017年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： びまん性大細胞型B細胞リンパ腫(DLBCL)は血液癌の最も一般的な型であり,顕著な遺伝的および臨床的不均一性によって特徴づけられる。この不均一性は,疾患の遺伝的基礎と治療への応答を理解するための主要な障害となっている。ここでは,疾患の150種の遺伝的運転者の景観を定義する包括的に1,001DLBCL患者のコホートにおける全エキソーム配列決定及びトランスクリプトーム配列決定の統合的解析を行った。は細胞増殖を促進する癌遺伝子を定義するDLBCL細胞系の不偏CRISPRスクリーンを用いてこれらの遺伝子の機能的影響を特性化した。これらの遺伝的変化を包括する予後モデルは,現在確立された方法より優れた性能を:起源の細胞,臨床的変数を含む国際予後指数,および二重MYCとBCL2発現。これらの結果は,疾患の新しい治療機会を同定するための遺伝的運転者とDLBCLにおけるそれらの機能的役割を定義する。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 治療法 ,  不均一性 ,  キャラクタリゼーション ,  トランスクリプトーム ,  患者 ,  細胞増殖 ,  *遺伝 ,  母集団 ,  癌遺伝子
準シソーラス用語： 予後指標 ,  細胞株 ,  エクソーム ,  血液癌 ,  *びまん性B細胞性大細胞型リンパ腫 , 【Automatic Indexing@JST】

著者キーワード (6件)： エキソーム配列決定 ,  遺伝的変異 ,  びまん性大細胞型B細胞リンパ腫 ,  DLBCL ,  TCGA ,  癌ゲノムアトラス

分類 (4件)： 発癌機序・因子  (GE02020C) ,  血液の腫よう  (GK04000M) ,  細胞生理一般  (EF02010S) ,  遺伝的変異  (EC01030Y)

タイトルに関連する用語 (3件)： びまん性大細胞型B細胞リンパ腫 ,  遺伝 ,  ドライバ