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Helicobacter pyloriはpH応答性BabA媒介接着を介して慢性感染と胃疾患に適応する【Powered by NICT】

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

著者 (70件)： Bugaytsova Jeanna A. (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Bjornham Oscar (Department of Applied Physics and Electronics, Umea University, 901 87 Umea, Sweden) ,  Chernov Yevgen A. (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Gideonsson Paer (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Henriksson Sara (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Mendez Melissa (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Sjostrom Rolf (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Mahdavi Jafar (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Mahdavi Jafar (School of Life Sciences, CBS, University of Nottingham, NG7 2RD Nottingham, UK) ,  Shevtsova Anna (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Ilver Dag (Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden) ,  Moonens Kristof (Structural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium) ,  Moonens Kristof (Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium) ,  Quintana-Hayashi Macarena P. (Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden) ,  Moskalenko Roman (Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine) ,  Aisenbrey Christopher (Department of Chemistry, Umea University, 901 87 Umea, Sweden) ,  Bylund Goran (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Schmidt Alexej (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Åberg Anna (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Braennstrom Kristoffer (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Koniger Verena (Max von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany) ,  Vikstrom Susanne (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Rakhimova Lena (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Rakhimova Lena (Department of Medical Biosciences, Umea University, 901 85 Umea, Sweden) ,  Hofer Anders (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  OEgren Johan (Department of Odontology, Umea University, 901 87 Umea, Sweden) ,  Liu Hui (Department of Medicine, USUHS, Bethesda, MD 20814, USA) ,  Goldman Matthew D. (Department of Pediatrics, USUHS, Bethesda, MD 20814, USA) ,  Whitmire Jeannette M. (Department of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA) ,  Åden Jorgen (Department of Chemistry, Umea University, 901 87 Umea, Sweden) ,  Younson Justine (King’s College London, Dental Institute, London SE1 9RT, UK) ,  Kelly Charles G. (King’s College London, Dental Institute, London SE1 9RT, UK) ,  Gilman Robert H. (Department of International Health, John Hopkins School of Public Health, Baltimore, MD 21205, USA) ,  Chowdhury Abhijit (Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education & Research, Kolkata 700020, India) ,  Mukhopadhyay Asish K. (Division of Bacteriology, National Institute of Cholera and Enteric Diseases P33, CIT Road, Kolkata 700010, India) ,  Nair G. Balakrish (Translational Health Science and Technology Institute 496, Phase-III, Udyog Vihar Gurgaon, 122016 Haryana, India) ,  Papadakos Konstantinos S. (Hellenic Pasteur Institute, Athens 11521, Greece) ,  Martinez-Gonzalez Beatriz (Hellenic Pasteur Institute, Athens 11521, Greece) ,  Sgouras Dionyssios N. (Hellenic Pasteur Institute, Athens 11521, Greece) ,  Engstrand Lars (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden) ,  Unemo Magnus (Department of Laboratory Medicine, Microbiology, OErebro University Hospital, 701 85 OErebro, Sweden) ,  Danielsson Dan (Department of Laboratory Medicine, Microbiology, OErebro University Hospital, 701 85 OErebro, Sweden) ,  Suerbaum Sebastian (Max von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany) ,  Suerbaum Sebastian (Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany) ,  Suerbaum Sebastian (German Center for Infection Research (DZIF), Hannover-Braunschweig Site, 30625 Hannover, Germany) ,  Suerbaum Sebastian (German Center for Infection Research (DZIF), Munich Site, 80336 Munich, Germany) ,  Oscarson Stefan (Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland) ,  Morozova-Roche Ludmilla A. (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Olofsson Anders (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Grobner Gerhard (Department of Chemistry, Umea University, 901 87 Umea, Sweden) ,  Holgersson Jan (Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden) ,  Esberg Anders (Department of Odontology, Umea University, 901 87 Umea, Sweden) ,  Stromberg Nicklas (Department of Odontology, Umea University, 901 87 Umea, Sweden) ,  Landstrom Marene (Department of Medical Biosciences, Umea University, 901 85 Umea, Sweden) ,  Eldridge Angela M. (Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA) ,  Chromy Brett A. (Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA) ,  Hansen Lori M. (Departments of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA) ,  Solnick Jay V. (Departments of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA) ,  Solnick Jay V. (California National Primate Research Center, University of California Davis School of Medicine, Davis, CA 95616, USA) ,  Linden Sara K. (Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden) ,  Haas Rainer (Max von Pettenkofer Institute of Hygiene and Medical Microbiology, LMU Munich, 80336 Munich, Germany) ,  Haas Rainer (German Center for Infection Research (DZIF), Munich Site, 80336 Munich, Germany) ,  Dubois Andre (Department of Medicine, USUHS, Bethesda, MD 20814, USA) ,  Merrell D. Scott (Department of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA) ,  Schedin Staffan (Department of Applied Physics and Electronics, Umea University, 901 87 Umea, Sweden) ,  Remaut Han (Structural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium) ,  Remaut Han (Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium) ,  Arnqvist Anna (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden) ,  Berg Douglas E. (Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA) ,  Boren Thomas (Department of Medical Biochemistry and Biophysics, Umea University, 901 87 Umea, Sweden)
資料名： Cell Host & Microbe  (Cell Host & Microbe)
巻： 21  号： 3  ページ： 376-389  発行年： 2017年 
JST資料番号： W2784A  ISSN： 1931-3128  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： BabAアドヘシンは抗原グリコシル化胃粘膜をABO血液型へのHelicobacter pyloriの高親和性結合を仲介する。BabAは酸応答性結合低pHで還元し,酸中和により回復することを示した。酸応答性は系統間で異なりしばしば異なる胃内領域と相関し,慢性感染と疾患進行中の発展高親和性結合BabA多量体の可逆的形成をBabAにおけるpHセンサ配列とpHに依存した。BabAの異常な可逆的酸応答性は,緊密な粘膜細菌付着を可能にするは酸性殺菌内腔に排出される上皮細胞および粘液から効果的に散逸することが出来る,こと及びbabA関連遺伝子変異と組換えを介してBabA結合特性におけるバイオ選択と変化は,個人間の差異と経時的胃液酸度の変化により選択されていることを提案した。これらの過程は多様なH.pylori亜集団,BabAの適応進化はH.pylori持続性と明白な胃疾患に寄与することを生成した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： pHセンサ ,  *感染 ,  殺菌 ,  *Helicobacter pylori ,  胃液 ,  親和性 ,  上皮細胞 ,  グリコシル化 ,  *接着 ,  酸性度 ,  *応答特性 ,  *胃疾患 ,  粘液 ,  多量体 ,  胃粘膜

著者キーワード (10件)： H elicobacter pylori ,  血液型抗原結合接着 ,  胃液酸度 ,  酸反応性 ,  適応 ,  diversity ,  多型 ,  亜集団 ,  multimerization ,  胃癌

分類 (1件)： 微生物感染の生理と病原性  (EG03053T)

タイトルに関連する用語 (7件)： Helicobacter ,  pH応答性 ,  BABA ,  慢性 ,  感染 ,  胃疾患 ,  適応