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J-GLOBAL ID：201702254442992599   整理番号：17A0924637

Ag^I媒介G:GおよびC:C塩基対を含むDNA構造【Powered by NICT】

A DNA Structure Containing Ag^I-Mediated G:G and C:C Base Pairs

著者 (15件)： Liu Hehua (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Shen Fusheng (Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA) ,  Haruehanroengra Phensinee (Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA) ,  Yao Qingqing (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Cheng Yunshan (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Chen Yiqing (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Yang Chun (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Zhang Jing (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Wu Baixing (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Luo Qiang (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Cui Ruixue (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Li Jixi (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Ma Jinbiao (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, 200433, China) ,  Sheng Jia (Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA) ,  Gan Jianhua (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China)
資料名： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition)
巻： 56  号： 32  ページ： 9430-9434  発行年： 2017年 
JST資料番号： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 金属媒介塩基対は,遺伝コード拡張,新規治療法開発,ナノデバイス設計を含む多くの研究分野で利用されている。他のカチオンと比較して,Ag^Iは天然塩基対との対合よりフレキシブルである。ここでは,短い8mer DNA鎖における二つのC-Ag^I-C対と最初に報告されたG-Ag^I-G対を含むDNA構造を提示した。この構造はDNAにおけるこれらのAg^I塩基対パターンへの詳細な洞察を提供するだけでなく,重金属イオンに駆動された最初の非ヘリックスDNA構造を示し,DNAの構造的多様性に寄与する。このユニークな複合体構造は高度に配列依存性であり,銀イオンを結合し,認識できる新しいDNAアプタマーとしての機能を示唆した。これらの結果は,Ag^Iと核酸塩基間の相互作用の理解を深めるだけでなく,新しいDNAナノデバイスの合理的設計のためのユニークな構造成分を提供した。Copyright 2018 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *金属イオン ,  *銀化合物 ,  塩基対 ,  *構造 ,  *DNA【核酸】 ,  固体素子
準シソーラス用語： *Ag^I ,  DNAアプタマー ,  DNAナノデバイス ,  *DNA構造 ,  ナノデバイス ,  *非ヘリックスDNA構造

著者キーワード (5件)： DNA構造 ,  金属媒介塩基対 ,  非螺旋状DNA ,  構造解明 ,  非天然塩基対

分類 (1件)： 核酸一般  (EB04010U)

タイトルに関連する用語 (3件)： AgI ,  塩基対 ,  DNA構造