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J-GLOBAL ID：201702255519122702   整理番号：17A0972196

小児および成人における注意欠陥多動性障害を有する参加者における皮質下脳容積の違い:横断的メガ解析【Powered by NICT】

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis

著者 (120件)： Hoogman Martine (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Hoogman Martine (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Bralten Janita (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Bralten Janita (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Hibar Derrek P (Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA) ,  Mennes Maarten (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Zwiers Marcel P (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Schweren Lizanne S J (Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands) ,  van Hulzen Kimm J E (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  van Hulzen Kimm J E (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Medland Sarah E (QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia) ,  Shumskaya Elena (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Shumskaya Elena (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Jahanshad Neda (Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA) ,  Zeeuw Patrick de (NICHE-lab, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands) ,  Szekely Eszter (Neurobehavioral Clinical Research Section, National Human Genome Research Institute, Bethesda, MD, USA) ,  Sudre Gustavo (Neurobehavioral Clinical Research Section, National Human Genome Research Institute, Bethesda, MD, USA) ,  Wolfers Thomas (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Wolfers Thomas (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Onnink Alberdingk M H (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Onnink Alberdingk M H (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Dammers Janneke T (Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands) ,  Dammers Janneke T (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Mostert Jeanette C (Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands) ,  Mostert Jeanette C (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Vives-Gilabert Yolanda (Asociacion para la Innovacion en Analisis, Gestion y Procesamiento de Datos Cientificos y Tecnologicos, Barcelona, Spain) ,  Kohls Gregor (Child Neuropsychology Section, University Hospital Aachen, Aachen, Germany) ,  Oberwelland Eileen (Child Neuropsychology Section, University Hospital Aachen, Aachen, Germany) ,  Oberwelland Eileen (JARA Translational Brain Medicine, Research Center Juelich, Aachen, Germany) ,  Seitz Jochen (Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany) ,  Schulte-Ruether Martin (Child Neuropsychology Section, University Hospital Aachen, Aachen, Germany) ,  Schulte-Ruether Martin (JARA Translational Brain Medicine, Research Center Juelich, Aachen, Germany) ,  Ambrosino Sara (NICHE-lab, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands) ,  Doyle Alysa E (Department of Psychiatry and Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA) ,  Doyle Alysa E (Stanley Center for Psychiatric Research at the Broad Institute, Cambridge, MA, USA) ,  Hovik Marie F (Department of Clinical Medicine, University of Bergen, Bergen, Norway) ,  Dramsdahl Margaretha (Psychiatry, Region Zealand, Denmark) ,  Tamm Leanne (Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA) ,  van Erp Theo G M (Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA) ,  Dale Anders (Departments of Neurosciences and Radiology, University of California, San Diego, San Diego, CA, USA) ,  Dale Anders (UCSD Center for Translational Imaging and Precision Medicine, San Diego, CA, USA) ,  Schork Andrew (Department of Cognitive Science, UC San Diego, La Jolla, CA, USA) ,  Conzelmann Annette (Department of Child and Adolescent Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany) ,  Conzelmann Annette (Department of Psychology, University of Wuerzburg, Wuerzburg, Germany) ,  Zierhut Kathrin (Department of Medical Psychology and Psychotherapy, Medical Sociology and Rehabilitation Sciences, University of Wuerzburg, Wuerzburg, Germany) ,  Zierhut Kathrin (Department of Psychology, University of Wuerzburg, Wuerzburg, Germany) ,  Baur Ramona (Department of Psychology, University of Wuerzburg, Wuerzburg, Germany) ,  McCarthy Hazel (Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland) ,  Yoncheva Yuliya N (The Child Study Center at NYU Langone Medical Center, New York, NY, USA) ,  Cubillo Ana (Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Chantiluke Kaylita (Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Mehta Mitul A (Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Paloyelis Yannis (Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Hohmann Sarah (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany) ,  Baumeister Sarah (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany) ,  Bramati Ivanei (D’Or Institute for Research and Education, Rio de Janeiro, Brazil) ,  Mattos Paulo (D’Or Institute for Research and Education, Rio de Janeiro, Brazil) ,  Mattos Paulo (Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil) ,  Tovar-Moll Fernanda (D’Or Institute for Research and Education, Rio de Janeiro, Brazil) ,  Tovar-Moll Fernanda (Morphological Sciences Program, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil) ,  Douglas Pamela (Department of Psychiatry, University of California, Los Angeles, CA, USA) ,  Banaschewski Tobias (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany) ,  Brandeis Daniel (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany) ,  Brandeis Daniel (Department of Child and Adolescent Psychiatry, Psychiatric Hospital, University of Zurich, Zurich, Switzerland) ,  Brandeis Daniel (Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland) ,  Brandeis Daniel (Neuroscience Centre Zurich, University of Zurich, Zurich, Switzerland) ,  Brandeis Daniel (ETH Zurich, Zurich, Switzerland) ,  Kuntsi Jonna (Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Asherson Philip (Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Rubia Katya (Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Kelly Clare (Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland) ,  Kelly Clare (The Child Study Center at NYU Langone Medical Center, New York, NY, USA) ,  Kelly Clare (Trinity College Institute of Neuroscience, Dublin, Ireland) ,  Martino Adriana Di (The Child Study Center at NYU Langone Medical Center, New York, NY, USA) ,  Milham Michael P (Center for the Developing Brain, Child Mind Institute, New York, NY, USA) ,  Milham Michael P (Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA) ,  Castellanos Francisco X (The Child Study Center at NYU Langone Medical Center, New York, NY, USA) ,  Castellanos Francisco X (Division of Child and Adolescent Psychiatric Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA) ,  Frodl Thomas (Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland) ,  Frodl Thomas (Department of Psychiatry and Psychotherapy, University Hospital, Otto-von-Guericke-University, Magdeburg, Germany) ,  Zentis Mariam (Department of Psychiatry and Psychotherapy, University Hospital, Otto-von-Guericke-University, Magdeburg, Germany) ,  Lesch Klaus-Peter (Division of Molecular Psychiatry, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany) ,  Lesch Klaus-Peter (Department of Translational Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands) ,  Reif Andreas (Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany) ,  Pauli Paul (Department of Psychology, University of Wuerzburg, Wuerzburg, Germany) ,  Jernigan Terry L (Departments of Cognitive Science, Psychiatry, Radiology, and Center for Human Development, University of California, San Diego, CA, USA) ,  Haavik Jan (KG Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway) ,  Haavik Jan (Department of Psychiatry, Haukeland University Hospital, Bergen, Norway) ,  Plessen Kerstin J (Child and Adolescent Mental Health Center, Capital Region, Denmark) ,  Lundervold Astri J (Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway) ,  Hugdahl Kenneth (Department of Psychiatry, Haukeland University Hospital, Bergen, Norway) ,  Hugdahl Kenneth (Department of Radiology, Haukeland University Hospital, Bergen, Norway) ,  Hugdahl Kenneth (Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway) ,  Seidman Larry J (Department of Psychiatry, Harvard Medical School, Boston, MA, USA) ,  Seidman Larry J (Beth Israel Deaconess Medical Center, Boston, MA, USA) ,  Biederman Joseph (Department of Psychiatry, Harvard Medical School, Boston, MA, USA) ,  Biederman Joseph (Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA) ,  Rommelse Nanda (Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands) ,  Rommelse Nanda (Karakter Child and Adolescent Psychiatry, Nijmegen, Netherlands) ,  Heslenfeld Dirk J (Department of Cognitive Psychology, VU University Amsterdam, Amsterdam, Netherlands) ,  Heslenfeld Dirk J (Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, Netherlands) ,  Hartman Catharina A (Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands) ,  Hoekstra Pieter J (Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands) ,  Oosterlaan Jaap (Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, Netherlands) ,  Polier Georg von (Child Neuropsychology Section, University Hospital Aachen, Aachen, Germany) ,  Konrad Kerstin (Child Neuropsychology Section, University Hospital Aachen, Aachen, Germany) ,  Vilarroya Oscar (Department of Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain) ,  Vilarroya Oscar (Fundacio IMIM, Barcelona, Spain) ,  Ramos-Quiroga Josep Antoni (Department of Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain) ,  Ramos-Quiroga Josep Antoni ,  Soliva Joan Carles (Department of Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain) ,  Durston Sarah (NICHE-lab, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands) ,  Buitelaar Jan K ,  Buitelaar Jan K (Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands) ,  Buitelaar Jan K (Karakter Child and Adolescent Psychiatry, Nijmegen, Netherlands) ,  Faraone Stephen V (KG Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway) ,  Faraone Stephen V ,  Shaw Philip (Neurobehavioral Clinical Research Section, National Human Genome Research Institute, Bethesda, MD, USA) ,  Shaw Philip ,  Thompson Paul M (Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA)
資料名： Lancet Psychiatry  (Lancet Psychiatry)
巻： 4  号： 4  ページ： 310-319  発行年： 2017年 
JST資料番号： W3023A  ISSN： 2215-0366  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 神経イメージング研究は,注意欠陥多動性障害(ADHD)の小児および成人におけるいくつかの脳領域の構造変化を示した。国際ENIGMA ADHDワーキンググループの形成を通して,我々は以前のイメージング研究およびメタ解析の弱点,すなわち不適切なサンプルサイズと方法論的不均一性を説明することを目的とした。はこの診断無しのそれらと比較してADHDの小児および成人における構造的差異があるかどうかを調べることを目的とした。この横断的メガ分析では,国際ENIGMAワーキンググループ共同研究からのデータ,この解析であった2015年2月8日で凍結を用いた。個々の部位は,この診断を持たない患者と比較して,ADHD患者の調和プロトコルによる構造T1強調MRI脳スキャンを分析した。第一の成果は,この共同で全てのコホートからのすべての個々のデータのプーリングによる皮質下構造と頭蓋内容積における症例対照差を評価することであった。この分析では,p値はp<00156のしきい値修正された偽発見率で顕著であった。サンプルは23か所からのADHD患者1529名および対照者1713人の参加者から構成されていた年齢中央値14歳(範囲4 63歳)であった。側坐核(Cohenのd= 015),扁桃体(d= 019),尾状(d= 011),海馬(d= 011),被殻(d= 014),と頭蓋内容積(d= 010)の体積はメガ分析における対照と比較して,ADHD患者でより小さかった。ADHDと対照者間の淡蒼球(p=095)および視床(p=039)における体積サイズの差はなかった。探索的寿命モデル化は,成熟の遅延と変性の遅延を示唆し,効果の大きさは,側坐核(Cohenのd= 019対 010),扁桃体(d= 018 vs 014),尾状(d= 013 vs 007),海馬(d= 012 vs 006),被殻(d= 018 vs 008),と頭蓋内容積(d= 014 vs 001)の子供(<15歳)と成人(>21歳)のサブグループで最高であった。pallidum(p=079)または視床(p=089)の小児と成人の差はなかった。成人における症例対照差異は非 有意(すべてp>003)であった。精神刺激薬物使用(全てp>015)または症状スコア(全てp>002)は結果に影響せず,併存精神疾患(すべてp>05)の存在を示した。今日までの最大のデータセットを用いて,著者らは両側扁桃体,側坐核,海馬減少ADHDにおけるに関する新しい知識を追加した。ADHDの脳成熟遅延理論を拡張し皮質下構造を含む,以前のメタ分析により示唆された脳容積に及ぼす薬物効果を否定した。寿命分析は,駆動縦断的研究の非存在下では,六桁年代のENIGMA断面試料は脳表現型の寿命軌跡についての仮説を生成する手段を提供することを示唆する。米国国立衛生研究所。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 患者 ,  精神病 ,  画像処理 ,  *子供 ,  *成人 ,  側坐核 ,  メタ分析 ,  中枢興奮薬 ,  扁桃核 ,  視床 ,  不均一性 ,  *皮質 ,  海馬 ,  表現型 ,  モデリング

分類 (2件)： 精神障害  (GR03000A) ,  精神科の臨床医学一般  (GR01030T)

タイトルに関連する用語 (7件)： 小児 ,  成人 ,  注意欠陥多動性障害 ,  参加者 ,  皮質 ,  脳容積 ,  解析