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J-GLOBAL ID：201702257673202323   整理番号：17A0969039

対単一細胞解析による早期肺腺癌における自然免疫景観【Powered by NICT】

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

著者 (61件)： Lavin Yonit (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Lavin Yonit (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Lavin Yonit (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kobayashi Soma (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kobayashi Soma (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kobayashi Soma (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Leader Andrew (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Leader Andrew (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Leader Andrew (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Amir El-ad David (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Amir El-ad David (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Amir El-ad David (Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Elefant Naama (Department of Immunology, Weizmann Institute, Rehovot 76100, Israel) ,  Bigenwald Camille (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Bigenwald Camille (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Bigenwald Camille (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Remark Romain (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Remark Romain (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Remark Romain (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sweeney Robert (Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sweeney Robert (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Becker Christian D. (Division of Pulmonology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Levine Jacob H. (Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA) ,  Meinhof Klaus (Division of Pulmonology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Chow Andrew (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Chow Andrew (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Chow Andrew (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kim-Shulze Seunghee (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kim-Shulze Seunghee (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kim-Shulze Seunghee (Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Wolf Andrea (Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Medaglia Chiara (Department of Immunology, Weizmann Institute, Rehovot 76100, Israel) ,  Li Hanjie (Department of Immunology, Weizmann Institute, Rehovot 76100, Israel) ,  Rytlewski Julie A. (Adaptive Biotechnologies Inc., Seattle, WA 98102, USA) ,  Emerson Ryan O. (Adaptive Biotechnologies Inc., Seattle, WA 98102, USA) ,  Solovyov Alexander (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Solovyov Alexander (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Solovyov Alexander (Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Solovyov Alexander (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Greenbaum Benjamin D. (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Greenbaum Benjamin D. (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Greenbaum Benjamin D. (Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Greenbaum Benjamin D. (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sanders Catherine (Adaptive Biotechnologies Inc., Seattle, WA 98102, USA) ,  Vignali Marissa (Adaptive Biotechnologies Inc., Seattle, WA 98102, USA) ,  Beasley Mary Beth (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Flores Raja (Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gnjatic Sacha (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gnjatic Sacha (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gnjatic Sacha (Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gnjatic Sacha (Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Pe’er Dana (Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA) ,  Rahman Adeeb (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Rahman Adeeb (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Rahman Adeeb (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Rahman Adeeb (Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Amit Ido (Department of Immunology, Weizmann Institute, Rehovot 76100, Israel) ,  Merad Miriam (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Merad Miriam (The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Merad Miriam (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Merad Miriam (Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 169  号： 4  ページ： 750-765.e17  発行年： 2017年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 早期肺腫瘍患者に対する免疫療法戦略の設計を導くために,著者らは,腫瘍主導型免疫変化を探索するために早期肺腺癌病変の免疫景観を地図化するための多重スケール免疫プロファイリング戦略を開発した。腫瘍,無関係な肺,血液細胞の同時単一細胞分析を可能にするバーコード法を利用して,著者らは初期肺腫瘍の詳細な免疫細胞地図を提供する。ステージI肺腺癌病変はすでに有意に変化したT細胞およびNK細胞コンパートメントを持っていることを示した。さらに,抗腫瘍T細胞免疫を損なう可能性があることを腫瘍浸潤骨髄細胞(TIM)サブセットの変化を同定した。対単一細胞分析は,腫瘍主導型免疫変化の貴重な知識を提供し,免疫療法の合理的設計のための強力なツールを提供した。ヌル表示省略Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 腫瘍浸潤 ,  肺腫瘍 ,  T細胞 ,  骨髄細胞 ,  患者 ,  マクロファージ ,  NK細胞 ,  免疫療法 ,  *自然免疫 ,  ヒト ,  腫瘍
準シソーラス用語： 免疫細胞 ,  *単一細胞 ,  *肺腺癌 ,  *単一細胞解析 , 【Automatic Indexing@JST】

著者キーワード (10件)： ヒト肺非小細胞癌(NSCLC) ,  肺腺癌 ,  CD141+DC ,  CD1c+DC ,  腫瘍マクロファージ ,  T細胞 ,  NK細胞 ,  TLS ,  TIM ,  免疫細胞地図

分類 (2件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： 単一細胞解析 ,  早期 ,  肺腺癌 ,  自然免疫 ,  景観