文献

J-GLOBAL ID：201702258127917067   整理番号：17A1533275

多環芳香族炭化水素によるCYP3A4誘導の機序は,PXR結合因子におけるリファンピシンのそれとは異なる。

CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element

著者 (10件)： Aratsu Yusuke (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Aratsu Yusuke (Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan tobacco Inc.) ,  Odagiri Reo (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Shoji Rie (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Watanabe Kouki (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Kumagai Takeshi (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Shindo Sawako (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Sasaki Takamitsu (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Sasaki Takamitsu (Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizoka) ,  Nagata Kiyoshi (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)
資料名： Fundamental Toxicological Sciences (Web)  (Fundamental Toxicological Sciences (Web))
巻： 4  号： 5  ページ： 229-239(J-STAGE)  発行年： 2017年 
JST資料番号： U0596A  ISSN： 2189-115X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： CYP3A4は,様々な化合物により誘導され,薬物間相互作用を...

シソーラス用語： *チトクロームP450 ,...
準シソーラス用語： *遺伝的調節 ,...

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著者キーワード (6件)： CYP3A4 induction ,  Pregnane X receptor ,  Rifampicin ,  Polycyclic aromatic hydrocarbons ,  Dibenz[ah]anthracene ,  PXR binding element

分類 (3件)： 生物薬剤学(基礎)  (GY01021U) ,  薬物の相互作用  (GV01070X) ,  抗生物質の薬理一般  (GX05010R)

物質索引 (2件)： アントラセン ,  リファンピシン

引用文献 (27件)：

• Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P. and Berkenstam, A. (1998): Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA, 95, 12208-12213.
• Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., Van Meter, C.M., Ong, E.S. and Evans, R.M. (1998): SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev., 12, 3195-3205.
• Drocourt, L., Ourlin, J.C., Pascussi, J.M., Maurel, P. and Vilarem, M.J. (2002): Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J. Biol. Chem., 277, 25125-25132.
• Elias, A., High, A.A., Mishra, A., Sien, S., Wu, J., Peng, J. and Chen, T. (2014): Identification and characterization of phosphorylation sites within the pregnane X receptor protein. Biochem. Pharmacol., 87, 360-370.
• EMA (2012): Guideline on the investigation of drug interactions. Guid. Doc., 44, 59.

タイトルに関連する用語 (6件)： 多環芳香族炭化水素 ,  CYP3A4 ,  誘導 ,  PXR ,  因子 ,  リファンピシン