文献

J-GLOBAL ID：201702258483973896   整理番号：17A0681745

蛋白質キナーゼCδのシグナル伝達は膵島からのグルカゴン分泌を制御する

Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets

著者 (8件)： Yamamoto Kiyotake (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Mizuguchi Hiroyuki (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tokashiki Natsumi (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Kobayashi Makoto (Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tamaki Motoyuki (Diabetes Therapeutics Research Center, Tokushima University) ,  Sato Youichi (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Fukui Hiroyuki (Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Yamauchi Aiko (Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School)
資料名： Journal of Medical Investigation (Web)  (Journal of Medical Investigation (Web))
巻： 64  号： 1.2  ページ： 122-128(J-STAGE)  発行年： 2017年 
JST資料番号： U0711A  ISSN： 1349-6867  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 「グルカゴン中心仮説」を支持するエビデンスが蓄積しており,こ...

シソーラス用語： *タンパク質キナーゼC ,...
準シソーラス用語： 細胞情報伝達

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著者キーワード (4件)： glucagon secretion ,  pancreatic α-cells ,  PKCδ ,  streptozotocin-induced diabetic mice

分類 (2件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  内分泌系の基礎医学  (GL01020Q)

引用文献 (34件)：

• 1. Ahrén B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A: Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 89: 2078-2084, 2004
• 2. Hare KJ, Vilsbøll T, Asmar M, Deacon CF, Knop FK, Holst JJ: The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 59: 1765-1770, 2010
• 3. Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ: Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494: 256-260, 2013
• 4. Raskin P, Unger RH: Effect of insulin therapy on the profiles of plasma immunoreactive glucagon in juvenile-type and adult-type diabetics. Diabetes 27: 411-419, 1978
• 5. Kielgast U, Holst JJ, Madsbad S: Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function. Diabetes 60: 1599-1607, 2011

タイトルに関連する用語 (5件)： 蛋白質キナーゼCδ ,  シグナル伝達 ,  膵島 ,  グルカゴン ,  分泌