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J-GLOBAL ID：201702260952711393   整理番号：17A1493210

脂肪組織機能を有するStat6/Pten軸リンク制御性T細胞【Powered by NICT】

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

著者 (46件)： Kaelin Stefanie (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Kaelin Stefanie (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Becker Maike (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Becker Maike (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Ott Verena B. (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Ott Verena B. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Ott Verena B. (Institute for Advanced Study, Technische Universitaet Muenchen, 85748 Garching, Germany) ,  Serr Isabelle (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Serr Isabelle (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Hosp Fabian (Max Planck Institute of Biochemistry, 82152 Martinsried, Germany) ,  Mollah Mohammad M.H. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Mollah Mohammad M.H. (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Keipert Susanne (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Keipert Susanne (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Lamp Daniel (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Lamp Daniel (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Rohner-Jeanrenaud Francoise (Laboratory of Metabolism, Division of Endocrinology, Diabetology, Hypertension, and Nutrition, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland) ,  Flynn Victoria K. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Flynn Victoria K. (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Scherm Martin G. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Scherm Martin G. (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Nascimento Lucas F.R. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Nascimento Lucas F.R. (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Gerlach Katharina (Department of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany) ,  Popp Vanessa (Department of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany) ,  Dietzen Sarah (Institute of Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany) ,  Bopp Tobias (Institute of Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany) ,  Krishnamurthy Purna (Department of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA) ,  Kaplan Mark H. (Department of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA) ,  Serrano Manuel (Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain) ,  Woods Stephen C. (Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA) ,  Tripal Philipp (OICE (Optical Imaging Centre Erlangen), University Erlangen, 91052 Erlangen, Germany) ,  Palmisano Ralf (OICE (Optical Imaging Centre Erlangen), University Erlangen, 91052 Erlangen, Germany) ,  Jastroch Martin (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Jastroch Martin (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Blueher Matthias (Department of Medicine, Research Group Molecular Endocrinology, University of Leipzig, 04103 Leipzig, Germany) ,  Wolfrum Christian (Swiss Federal Institute of Technology, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, ETH Zurich, 8603 Schwerzenbach, Switzerland) ,  Weigmann Benno (Department of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany) ,  Ziegler Anette-Gabriele (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Ziegler Anette-Gabriele (Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Ziegler Anette-Gabriele (Klinikum rechts der Isar, Technische Universitaet Muenchen, 80333 Munich, Germany) ,  Mann Matthias (Max Planck Institute of Biochemistry, 82152 Martinsried, Germany) ,  Tschop Matthias H. (Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen and Division of Metabolic Diseases, Department of Medicine, Technische Universitaet Muenchen, 85748 Munich, Germany) ,  Tschop Matthias H. (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany) ,  Daniel Carolin (Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum Muenchen, 80939 Munich, Germany) ,  Daniel Carolin (German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany)
資料名： Cell Metabolism  (Cell Metabolism)
巻： 26  号： 3  ページ： 475-492.e7  発行年： 2017年 
JST資料番号： W3108A  ISSN： 1550-4131  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 肥満と2型糖尿病は代謝障害および脂肪組織炎症と関連している。Foxp3~+調節性T細胞(T_regs)は局所炎症を打ち消すことによって組織ホメオスタシスを制御する。,T細胞は脂肪細胞機能と環境影響を連結かは知られていない。ここでは,寒冷曝露,beta3 アドレネルグ酸受容体(ADRB3)刺激または短期高カロリー食による交感神経系の緊張を増強するin vitroおよびin vivo T_reg誘導を促進することを報告する。CD4~+T細胞プロテオームをT_reg誘導を反映したin vivo低温またはADRB3刺激に応答してFoxp3調節ネットワークのより高い発現を明らかにした。特に,mTORC1活性を制限するRegulator相互作用蛋白質C17orf59はADRB3刺激または寒冷曝露のいずれかによるCD4~+T細胞でアップレギュレートされ,T_reg誘導への寄与を示唆した。損失および機能獲得研究,in vivo T_reg枯渇と移動を含むことにより,著者らは,T細胞特異的Stat6/Pten軸はFoxp3~+T_reg誘導と脂肪組織機能と寒冷曝露あるいはADRB3刺激を結びつけることを示した。著者らの知見は,組織特異的T_regsは脂肪組織機能を維持する新しい機械的モデルを提供する。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 炎症 ,  代謝 ,  環境影響 ,  2型糖尿病 ,  相互作用 ,  交感神経系 ,  ホメオスタシス ,  *脂肪組織 ,  寒冷曝露 ,  代謝異常 ,  タンパク質 ,  in vitro実験 ,  *T細胞 ,  脂肪細胞
準シソーラス用語： FoxP3 , 【Automatic Indexing@JST】

著者キーワード (12件)： 調節性T細胞 ,  T_regs ,  T細胞 ,  脂肪組織機能 ,  寒冷暴露 ,  代謝機能 ,  metabolism ,  Foxp3 ,  STAT6 ,  PTEN ,  C17orf59 ,  Borcs6

分類 (2件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  免疫反応一般  (ED03010T)

タイトルに関連する用語 (5件)： 脂肪組織 ,  STAT6 ,  PTEN ,  リンク ,  制御性T細胞