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J-GLOBAL ID：201702261445662217   整理番号：17A1429513

院外感染性肺炎における抗生物質療法の個別化期間【Powered by NICT】

Individualizing duration of antibiotic therapy in community-acquired pneumonia

著者 (24件)： Aliberti Stefano (Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy) ,  Ramirez Julio (University of Louisville, School of Medicine, Department of Medicine, Division of Infectious Diseases, Louisville, KY, United States) ,  Giuliani Fabio (Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy) ,  Wiemken Timothy (University of Louisville, School of Medicine, Department of Medicine, Division of Infectious Diseases, Louisville, KY, United States) ,  Sotgiu Giovanni (Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari - Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy) ,  Tedeschi Sara (Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant’Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, Italy) ,  Carugati Manuela (Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Milan, Italy) ,  Valenti Vincenzo (Department of Health Bioscience, University of Milan - Respiratory Unit, Policlinico di San Donato, IRCCS - San Donato Milanese, Milan, Italy) ,  Marchioni Marco (ASST Carlo Poma, Mantova, Italy) ,  Camera Marco (Clinica Malattie Infettive, DIPMI, DISSAL, IRCCS AOU San Martino-IST, Universita di Genova, Genova, Italy) ,  Piro Roberto (Pulmonology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy) ,  Del Forno Manuela (Respiratory and Critical Care, Sant’Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Bologna, Italy) ,  Milani Giuseppe (UO Pneumologia, ASST Lariana Ospedale S.Anna, S. Fermo della Battaglia, Como, Italy) ,  Faverio Paola (School of Medicine and Surgery, University of Milan Bicocca, San Gerardo Hospital, Monza, Italy) ,  Richeldi Luca (National Institute for Health Research Respiratory Biomedical Research Unit, Mailpoint 813, LE75 E Level, South Academic Block, University Hospital Southampton NHS Foundation Trust, Southampton, UK) ,  Deotto Martina (Division of Internal Medicine, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine, Italy) ,  Villani Massimiliano (Dipartimento Cardio-Respiratorio, Unita Operativa di Pneumologia, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy) ,  Voza Antonio (U.O. di Pronto Soccorso e Medicina d’Urgenza, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy) ,  Tobaldini Eleonora (Fondazione IRCSS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy) ,  Tobaldini Eleonora (Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy) ,  Bernardi Mauro (Semeiotica Medica, Policlinico Sant’Orsola Malpighi, Alma Mater Studiorum, University of Bologna, Bologna, Italy) ,  Bellone Andrea (Department of Emergency Medicine, San Anna Hospital, San Fermo della Battaglia, Como, Italy) ,  Bassetti Matteo (Santa Maria Misericordia University Hospital, Infectious Diseases Division, Udine, Italy) ,  Blasi Francesco (Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy)
資料名： Pulmonary Pharmacology & Therapeutics  (Pulmonary Pharmacology & Therapeutics)
巻： 45  ページ： 191-201  発行年： 2017年 
JST資料番号： T0708A  ISSN： 1094-5539  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 国際専門家は患者の特性に応じた市中肺炎(CAP)における調整抗生物質投与期間を示唆した。CAP患者は入院中の臨床的安定性の到達時間に基づいて抗生物質持続時間に個別化されたアプローチの有効性を評価することを目的とした。多施設共同,非劣性,無作為化,比較試験では入院後5日以内に臨床的安定に達するCAPと入院成人患者は標準対個別抗生物質投与期間に無作為化した。個別群では,抗生物質は患者は臨床的安定に達し,少なくとも五日間全抗生物質処理の48時間後に中止した。30日以内の早期破壊が1次複合性結果であった。135名の患者は標準群に無作為化されたおよび125個別群。試験は,標準治療上の個別群の見かけの不良のため安全委員会により中断された:個別化群で14(11.2%)の患者はintention-to-treat分析で,p<0.200,標準群で10(7.4%)患者対早期破壊を経験した。30日死亡率は,標準群よりも個別群で四時間高かった。患者の特性に応じた抗生物質投与期間を短縮まだ未解決の問題である。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 安全性 ,  入院 ,  比較試験 ,  患者 ,  死亡率 ,  成人 ,  *抗生物質 ,  継続時間 ,  投与期間 ,  劣性
準シソーラス用語： 標準的治療 ,  到達時間 ,  抗生物質療法 ,  *院外感染性肺炎 , 【Automatic Indexing@JST】

分類 (1件)： 呼吸器の診断  (GI02000S)

タイトルに関連する用語 (2件)： 院外感染性肺炎 ,  抗生物質療法