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J-GLOBAL ID：201702263696003024   整理番号：17A1434103

機能的変異体を含む遺伝子-環境相互作用:乳癌関連コンソーシアムからの結果【Powered by NICT】

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

著者 (70件)： Barrdahl Myrto (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Rudolph Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Hopper John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia) ,  Southey Melissa C. (Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia) ,  Broeks Annegien (Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands) ,  Fasching Peter A. (Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany) ,  Fasching Peter A. (David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA) ,  Beckmann Matthias W. (Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany) ,  Gago-Dominguez Manuela (Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude, SERGAS, Santiago De Compostela, Spain) ,  Gago-Dominguez Manuela (Moores Cancer Center, University of California San Diego, La Jolla, CA) ,  Castelao J. Esteban (Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain) ,  Guenel Pascal (CESP-Cancer and Environment team, INSERM U1018, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France) ,  Truong Therese (CESP-Cancer and Environment team, INSERM U1018, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France) ,  Bojesen Stig E. (Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark) ,  Bojesen Stig E. (Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark) ,  Bojesen Stig E. (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Gapstur Susan M. (Epidemiology Research Program, American Cancer Society, Atlanta, GA) ,  Gaudet Mia M. (Epidemiology Research Program, American Cancer Society, Atlanta, GA) ,  Brenner Hermann (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Brenner Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany) ,  Brenner Hermann (German Cancer Consortium (DKTK), Heidelberg, Germany) ,  Arndt Volker (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Brauch Hiltrud (German Cancer Consortium (DKTK), Heidelberg, Germany) ,  Brauch Hiltrud (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany) ,  Brauch Hiltrud (University of Tuebingen, Tuebingen, Germany) ,  Hamann Ute (Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Mannermaa Arto (Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland) ,  Mannermaa Arto (Pathology and Forensic Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland) ,  Mannermaa Arto (Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland) ,  Lambrechts Diether (Vesalius Research Center, VIB, Leuven, Belgium) ,  Lambrechts Diether (Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium) ,  Jongen Lynn (Leuven Multidisciplinary Breast Center, Department of Oncology, KU Leuven and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium) ,  Flesch-Janys Dieter (Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Flesch-Janys Dieter (Department of Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Thoene Kathrin (Department of Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Couch Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN) ,  Giles Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia) ,  Giles Graham G. (Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia) ,  Simard Jacques (Genomics Center, Centre Hospitalier Universitaire de Quebec Research Center, Laval University, Quebec City, QC, Canada) ,  Goldberg Mark S. (Department of Medicine, McGill University, Montreal, QC, Canada) ,  Goldberg Mark S. (Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada) ,  Figueroa Jonine (Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Teviot Place Edinburgh, Edinburgh, United Kingdom) ,  Figueroa Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD) ,  Michailidou Kyriaki (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Michailidou Kyriaki (Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, Nicosia) ,  Bolla Manjeet K. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Dennis Joe (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Wang Qin (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Eilber Ursula (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Behrens Sabine (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Czene Kamila (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Hall Per (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Cox Angela (Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom) ,  Cross Simon (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom) ,  Swerdlow Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, London, United Kingdom) ,  Swerdlow Anthony (Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, London, United Kingdom) ,  Schoemaker Minouk J. (Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, London, United Kingdom) ,  Dunning Alison M. (Department of Oncology, University of Cambridge, Worts Causeway, Centre for Cancer Genetic Epidemiology, Cambridge, United Kingdom) ,  Kaaks Rudolf (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Pharoah Paul D.P. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Pharoah Paul D.P. (Department of Oncology, University of Cambridge, Worts Causeway, Centre for Cancer Genetic Epidemiology, Cambridge, United Kingdom) ,  Schmidt Marjanka (Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands) ,  Schmidt Marjanka (Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands) ,  Garcia-Closas Montserrat (Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD) ,  Easton Douglas F. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, United Kingdom) ,  Easton Douglas F. (Department of Oncology, University of Cambridge, Worts Causeway, Centre for Cancer Genetic Epidemiology, Cambridge, United Kingdom) ,  Milne Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia) ,  Milne Roger L. (Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia) ,  Chang-Claude Jenny (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Chang-Claude Jenny (Research Group Genetic Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany)
資料名： International Journal of Cancer  (International Journal of Cancer)
巻： 141  号： 9  ページ： 1830-1840  発行年： 2017年 
JST資料番号： A0267B  ISSN： 0020-7136  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： マッピング分析により同定された最も可能性がある原因変異体の研究遺伝子-環境相互作用を検出するための能力を改善する可能性がある。乳癌に関連した感受性遺伝子座と11疫学的乳癌リスク因子の遺伝的微細マッピングにより同定された70の単一ヌクレオチド多型の間の相互作用を評価した。分析は乳癌関連コンソーシアムからの58,573人の被験者(26,968症例と31,605対照)を行い,その種の最も大規模な検討の1つであった。分析はエストロゲン受容体(ER)陽性(ER+)とER陰性(ER )疾患に分けて行った。Bayes誤り発見確率(BFDP)は結果のnoteworthinessを評価するために計算した。0.01の真の前相互作用確率を仮定した場合,四個の潜在的遺伝子-環境相互作用は注目すべきとして同定された(BFDP<0.80)。全体の乳癌リスクに関連した最も強い相互作用結果はCFLAR rs7558475と現在の喫煙(OR_int=0.77;95%CI:0.67 0.88,p_int=1.8×10~ 4)の間で見いだした。最も強い統計的証拠との相互作用はER疾患リスクに関連した5q14rs7707921とアルコール消費(OR_int=1.36;95%CI:1.16 1.59,p_int=1.9×10~ 5)の間で見いだした。残りの二遺伝子-環境相互作用はエストロゲン受容体(ER)乳癌リスクとの関連で同定され,初潮(OR_int=1.26,95%CI:1.12 1.43,p_int=1.8×10~ 4)と最初の満期妊娠(OR_int=0.89;95%CI:0.83 0.95,p_int=5.2×10~ 4)で8q23rs13267382と年齢の間の3p21rs6796502と年齢間に見られた。これらの結果は,強い遺伝子-環境相互作用を示唆しないが,著者らの結果はまだ実験研究の情報を得るために有用である可能性がある。それらのことは,次々に,観察された潜在的相互作用に光を当てるであろう。Copyright 2017 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *乳房腫瘍 ,  危険因子 ,  妊娠 ,  喫煙 ,  *遺伝 ,  *遺伝子 ,  エストロゲン受容体 ,  *相互作用 ,  疫学 ,  一塩基多型
準シソーラス用語： 初潮 ,  乳癌のリスク ,  被験者 ,  感受性遺伝子 ,  *コンソーシアム , 【Automatic Indexing@JST】

著者キーワード (5件)： 乳癌 ,  一塩基多型 ,  乳癌関連コンソーシアム ,  遺伝子-環境 ,  相互作用

分類 (1件)： 臨床腫よう学一般  (GE03010Y)

タイトルに関連する用語 (6件)： 変異体 ,  遺伝子 ,  環境 ,  相互作用 ,  乳癌 ,  コンソーシアム