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J-GLOBAL ID：201702269070764195   整理番号：17A1559844

統合失調症に関連する年齢とのグローバルなDNAヒドロキシメチル化の変化【Powered by NICT】

Variation in global DNA hydroxymethylation with age associated with schizophrenia

著者 (19件)： Jiang Tingyun (Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China) ,  Jiang Tingyun (The Third People’s Hospital of Zhongshan, Zhongshan, Guangdong, China) ,  Zong Lu (Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China) ,  Zong Lu (Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, Guangdong, China) ,  Zhou Lin (Key Laboratory of Genetics and Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, China) ,  Hou Yu (Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China) ,  Hou Yu (Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, Guangdong, China) ,  Zhang Lulu (Department of Psychiatry, Guangzhou First People’s Hospital, Guangzhou, Guangdong, China) ,  Zheng Xianzhen (Guangdong General Hospital, Guangdong Academy of Medical Science and Guangdong Mental Health Center, Guangzhou, China) ,  Han Hongying (Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China) ,  Li Shufen (Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China) ,  Li Shufen (Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, Guangdong, China) ,  Zhang Wenwei (The Third People’s Hospital of Zhongshan, Zhongshan, Guangdong, China) ,  Zhang Jian (Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China) ,  Zhang Jian (Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, Guangdong, China) ,  Deng Cong (The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China) ,  Jia Yanbin (Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China) ,  Zhao Cunyou (Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China) ,  Zhao Cunyou (Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, Guangdong, China)
資料名： Psychiatry Research  (Psychiatry Research)
巻： 257  ページ： 497-500  発行年： 2017年 
JST資料番号： A1184A  ISSN： 0165-1781  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 統合失調症の発症におけるDNAヒドロキシメチル化(5hmC)とメチル化(5mC)の理解を改善するために,本研究は,統合失調症と対照221の264人の患者の末梢血液DNAにおける全体的な5hmCと5MCレベルを調べた患者における増加した5MCレベルを観測し,男性患者における5hmCレベルを増加させたが,対照と比較して,女性患者におけるレベルを低下させた。5mCレベルは年齢とともに依存的な正の相関を示し,5hmC量は,対照における正は負患者の年齢との相関を示し,統合失調症の病因におけるその役割は解明されていない。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 男性 ,  *メチル化 ,  *統合失調症 ,  患者 ,  病因 ,  *DNA【核酸】 ,  末梢血
準シソーラス用語： 女性患者 ,  *ヒドロキシメチル化 , 【Automatic Indexing@JST】

著者キーワード (3件)： 5hmC ,  5MC ,  DNA修飾

分類 (1件)： 精神障害  (GR03000A)

タイトルに関連する用語 (4件)： 統合失調症 ,  年齢 ,  DNA ,  ヒドロキシメチル化