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J-GLOBAL ID：201702270494162110   整理番号：17A1444644

細胞アポトーシスとアミノ酸代謝に及ぼすリジン欠乏とLys Lysジペプチドの影響【Powered by NICT】

Effects of Lysine deficiency and Lys-Lys dipeptide on cellular apoptosis and amino acids metabolism

著者 (62件)： Yin Jie (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Yin Jie (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Yin Jie (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Yin Jie (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Li Yuying (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Li Yuying (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Li Yuying (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Li Yuying (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Han Hui (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Han Hui (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Han Hui (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Han Hui (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Zheng Jie (College of Animal Science and Technology, Hunan Agriculture University, Hunan, P. R. China) ,  Wang Lijian (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Wang Lijian (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Wang Lijian (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Wang Lijian (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Ren Wenkai (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Ren Wenkai (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Ren Wenkai (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Ren Wenkai (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Chen Shuai (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Chen Shuai (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Chen Shuai (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Chen Shuai (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Wu Fei (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Wu Fei (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Wu Fei (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Wu Fei (University of Chinese Academy of Sciences, Beijing, P. R. China) ,  Fang Rejun (College of Animal Science and Technology, Hunan Agriculture University, Hunan, P. R. China) ,  Fang Rejun (Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan, P. R. China) ,  Huang Xingguo (College of Animal Science and Technology, Hunan Agriculture University, Hunan, P. R. China) ,  Huang Xingguo (Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine, Guangdong Wangda Group Co., Ltd., GuangDong, P. R. China) ,  Huang Xingguo (Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan, P. R. China) ,  Li Chunyong (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Li Chunyong (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Li Chunyong (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Tan Bie (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Tan Bie (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Tan Bie (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Xiong Xia (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Xiong Xia (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Xiong Xia (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Zhang Yuzhe (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Zhang Yuzhe (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Zhang Yuzhe (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Liu Gang (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Liu Gang (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Liu Gang (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Yao Jiming (College of Animal Science and Technology, Hunan Agriculture University, Hunan, P. R. China) ,  Yao Jiming (Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine, Guangdong Wangda Group Co., Ltd., GuangDong, P. R. China) ,  Li Tiejun (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Li Tiejun (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Li Tiejun (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Li Tiejun (Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine, Guangdong Wangda Group Co., Ltd., GuangDong, P. R. China) ,  Li Tiejun (Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan, P. R. China) ,  Li Tiejun (National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan, P. R. China) ,  Yin Yulong (Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, P. R. China) ,  Yin Yulong (Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan, P. R. China) ,  Yin Yulong (Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, P. R. China) ,  Yin Yulong (Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine, Guangdong Wangda Group Co., Ltd., GuangDong, P. R. China) ,  Yin Yulong (National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan, P. R. China)
資料名： Molecular Nutrition & Food Research  (Molecular Nutrition & Food Research)
巻： 61  号： 9  ページ： ROMBUNNO.201600754  発行年： 2017年 
JST資料番号： H0535A  ISSN： 1613-4125  CODEN： MNFRCV  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： リジン(Lys)はヒトおよび動物の共通の制限アミノ酸(AA)であり,細胞増殖と代謝に重要な役割を果たし,Lys欠乏とそのジペプチドの代謝は未だ不明である。このように,本研究は主にin vitroおよびin vivoモデルアポトーシスとAA代謝に及ぼすLys欠乏とLys-Lysジペプチドの影響を調べた。【方法】と結果:Lys欠乏は細胞周期停止とアポトーシスを誘導し,in vitroおよびin vivoでのLys輸送体をアップレギュレートした。シスチン-グルタミン酸交換輸送体,SLC7A11はLys欠乏により著しくアップレギュレートし,さらにシスチン取込とグルタミン酸放出,シスチンおよびグルタミン酸輸送体により負に調節されたを仲介した。一方,Lys欠乏はpept1発現を減少させ,それがLysアベイラビリティを補償するLys-Lysジペプチド吸収を改善する可能性があることをアップレギュレートした。Lys-Lysジペプチド軽減Lys欠乏は細胞周期停止とアポトーシスを誘導し,AA代謝に影響した。さらに,ラパマイシンの哺乳類標的はセンシング細胞Lys飢餓とLys-Lysジペプチドに関与している可能性がある。【結論】まとめると,これらの研究は,Lys欠乏はAA代謝を障害し,アポトーシスを生じることを示す。Lys-LysジペプチドはLys源として役立ち,Lys欠乏誘導される細胞の不均衡を軽減する。Copyright 2017 Wiley Publishing Japan K.K. All Rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 制限アミノ酸 ,  哺乳類 ,  *ジペプチド ,  細胞増殖 ,  *アポトーシス ,  ヒト ,  アベイラビリティ ,  in vitro実験 ,  *アミノ酸代謝 ,  *代謝 ,  エーテル ,  大環状化合物 ,  ラクタム ,  ラクトン ,  酵素阻害剤 ,  ヘミアセタール ,  脂環式アルコール ,  第二アルコール ,  ヒドロキシケトン ,  ジスルフィド ,  脂肪族アミン ,  脂肪族カルボン酸 ,  含硫アミノ酸 ,  第一アミン ,  アミノ酸
準シソーラス用語： 輸送体 ,  細胞周期停止 , 【Automatic Indexing@JST】

著者キーワード (4件)： アミノ酸代謝 ,  アポトーシス ,  Dipeptide ,  リジン

分類 (2件)： 抗腫よう薬の基礎研究  (GW16010A) ,  腫ようの化学・生化学・病理学  (GE02030N)

物質索引 (3件)： ラパマイシン ,  シスチン ,  リジン

タイトルに関連する用語 (6件)： 細胞アポトーシス ,  アミノ酸代謝 ,  リジン ,  欠乏 ,  Lys ,  ジペプチド