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J-GLOBAL ID：201702273490222998   整理番号：17A1418027

2ゲノムワイド関連の解析は広範なうつ病表現型のための新しい遺伝子座を同定するメタ分析【Powered by NICT】

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

著者 (120件)： Direk Nese (Department of Epidemiology, Erasmus University Medical Center, Rotterdam) ,  Direk Nese (Department of Psychiatry, Dokuz Eylul University, Izmir, Turkey) ,  Williams Stephanie (Department of Genetics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina) ,  Smith Jennifer A. (Department of Epidemiology, University of Michigan, Ann Arbor, Michigan) ,  Ripke Stephan (Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge) ,  Ripke Stephan (Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston) ,  Ripke Stephan (Department of Psychiatry and Psychotherapy, Charite, Campus Mitte, Berlin) ,  Air Tracy (Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia) ,  Amare Azmeraw T. (Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen) ,  Amare Azmeraw T. (Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia) ,  Amin Najaf (Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam) ,  Baune Bernhard T. (Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia) ,  Bennett David A. (Rush Alzheimer’s Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois) ,  Blackwood Douglas H.R. (Division of Psychiatry, University of Edinburgh, Edinburgh) ,  Boomsma Dorret (Department of Biological Psychology, VU University, Amsterdam, The Netherlands) ,  Breen Gerome (MRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London) ,  Buttenschon Henriette N. (Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus) ,  Buttenschon Henriette N. (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus) ,  Byrne Enda M. (Queensland Brain Institute, University of Queensland, St. Lucia, Queensland) ,  Borglum Anders D. (Department of Biomedicine and Centre for Integrative Sequencing, Aarhus University, Aarhus) ,  Borglum Anders D. (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus) ,  Castelao Enrique (Department of Psychiatry, Lausanne University Hospital, Lausanne) ,  Cichon Sven (Institute of Human Genetics, University of Bonn, Bonn) ,  Cichon Sven (Department of Genomics, Life & Brain Center, Bonn) ,  Cichon Sven (Institute of Neuroscience and Medicine, Research Centre Juelich, Juelich) ,  Cichon Sven (Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland) ,  Clarke Toni-Kim (Division of Psychiatry, University of Edinburgh, Edinburgh) ,  Cornelis Marilyn C. (Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois) ,  Dannlowski Udo (Department of Psychiatry and Psychotherapy, University of Muenster, Muenster) ,  De Jager Philip L. (Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge) ,  De Jager Philip L. (Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital, Harvard Medical School, Boston) ,  De Jager Philip L. (Department of Neurology, Harvard Medical School, Boston) ,  Demirkan Ayse (Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam) ,  Domenici Enrico (Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland) ,  Domenici Enrico (Centre for Integrative Biology, University of Trento, Trento, Italy) ,  van Duijn Cornelia M. (Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam) ,  Dunn Erin C. (Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge) ,  Dunn Erin C. (Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston) ,  Dunn Erin C. (Department of Psychiatry, Harvard Medical School, Boston) ,  Eriksson Johan G. (National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki) ,  Eriksson Johan G. (Department of General Practice and Primary Health Care, University of Helsinki, Helsinki) ,  Eriksson Johan G. (Unit of General Practice, Helsinki University Central Hospital, Helsinki) ,  Eriksson Johan G. (Folkhalsan Research Centre, Helsinki) ,  Eriksson Johan G. (Vasa Central Hospital, Vasa, Finland) ,  Esko Tonu (Program in Medical and Populational Genetics, The Broad Institute of Harvard and MIT, Cambridge) ,  Esko Tonu (Division of Endocrinology, Boston Children’s Hospital, Cambridge) ,  Esko Tonu (Department of Genetics, Harvard Medical School, Boston) ,  Esko Tonu (Estonian Genome Center, University of Tartu, Tartu, Estonia) ,  Faul Jessica D. (Institute for Social Research, University of Michigan, Ann Arbor, Michigan) ,  Ferrucci Luigi (Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland) ,  Fornage Myriam (Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas) ,  de Geus Eco (Department of Biological Psychology, VU University, Amsterdam, The Netherlands) ,  Gill Michael (Department of Psychiatry, Trinity Centre for Health Science, Dublin, Ireland) ,  Gordon Scott D. (QIMR Berghofer Medical Research Institute, Brisbane) ,  Grabe Hans Jorgen (Department of Psychiatry and Psychotherapy, Helios Hospital Stralsund, Munich) ,  Grabe Hans Jorgen (Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Munich) ,  Grabe Hans Jorgen (German Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Munich) ,  van Grootheest Gerard (Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands) ,  Hamilton Steven P. (Department of Psychiatry, Kaiser Permanente San Francisco Medical Center, San Francisco) ,  Hartman Catharina A. (Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen) ,  Heath Andrew C. (Department of Psychiatry, Washington University, St. Louis, Missouri) ,  Hek Karin (Department of Epidemiology, Erasmus University Medical Center, Rotterdam) ,  Hek Karin (Department of Psychiatry, Erasmus University Medical Center, Rotterdam) ,  Hofman Albert (Department of Epidemiology, Erasmus University Medical Center, Rotterdam) ,  Homuth Georg (Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Munich) ,  Horn Carsten (Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland) ,  Jan Hottenga Jouke (Department of Biological Psychology, VU University, Amsterdam, The Netherlands) ,  Kardia Sharon L.R. (Department of Epidemiology, University of Michigan, Ann Arbor, Michigan) ,  Kloiber Stefan (Max Planck Institute of Psychiatry, Munich) ,  Koenen Karestan (Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York) ,  Kutalik Zoltan (Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne) ,  Ladwig Karl-Heinz (Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich) ,  Ladwig Karl-Heinz (Institute of Epidemiology II, Mental Health Research Unit, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg) ,  Lahti Jari (Folkhalsan Research Centre, Helsinki) ,  Lahti Jari ,  Levinson Douglas F. ,  Lewis Cathryn M. (MRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London) ,  Lewis Glyn ,  Li Qingqin S. ,  Llewellyn David J. ,  Lucae Susanne (Max Planck Institute of Psychiatry, Munich) ,  Lunetta Kathryn L. ,  Lunetta Kathryn L. ,  MacIntyre Donald J. (Division of Psychiatry, University of Edinburgh, Edinburgh) ,  Madden Pamela (Department of Psychiatry, Washington University, St. Louis, Missouri) ,  Martin Nicholas G. (QIMR Berghofer Medical Research Institute, Brisbane) ,  McIntosh Andrew M. (Division of Psychiatry, University of Edinburgh, Edinburgh) ,  Metspalu Andres (Estonian Genome Center, University of Tartu, Tartu, Estonia) ,  Metspalu Andres ,  Milaneschi Yuri (Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands) ,  Montgomery Grant W. (QIMR Berghofer Medical Research Institute, Brisbane) ,  Mors Ole (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus) ,  Mors Ole ,  Mosley Thomas H. ,  Murabito Joanne M. ,  Murabito Joanne M. ,  Mueller-Myhsok Bertram (Max Planck Institute of Psychiatry, Munich) ,  Mueller-Myhsok Bertram ,  Mueller-Myhsok Bertram ,  Nothen Markus M. (Institute of Human Genetics, University of Bonn, Bonn) ,  Nothen Markus M. (Department of Genomics, Life & Brain Center, Bonn) ,  Nyholt Dale R. (QIMR Berghofer Medical Research Institute, Brisbane) ,  Nyholt Dale R. ,  O’Donovan Michael C. ,  Penninx Brenda W. (Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands) ,  Pergadia Michele L. (Department of Psychiatry, Washington University, St. Louis, Missouri) ,  Pergadia Michele L. ,  Perlis Roy ,  Potash James B. ,  Preisig Martin (Department of Psychiatry, Lausanne University Hospital, Lausanne) ,  Purcell Shaun M. ,  Quiroz Jorge A. ,  Quiroz Jorge A. (Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland) ,  Raeikkonen Katri ,  Rice John P. (Department of Psychiatry, Washington University, St. Louis, Missouri) ,  Rietschel Marcella ,  Rivera Margarita (MRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London) ,  Rivera Margarita ,  Rivera Margarita ,  Schulze Thomas G.
資料名： Biological Psychiatry  (Biological Psychiatry)
巻： 82  号： 5  ページ： 322-329  発行年： 2017年 
JST資料番号： T0089A  ISSN： 0006-3223  CODEN： BIPCBF  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： うつ病の遺伝学は陰性所見を伴う大うつ病性障害あるいは抑うつ症状のいずれかに焦点を当てたゲノムワイド関連研究で調べた。両表現型を含む広い抑制表現型は,ゲノムワイド相関解析法を用いて以前に検証されていない。大うつ病性障害に対する抑うつ症状の広い表現型と有意に関連して遺伝的多型を同定することを目的とした。発見段階における一般的および臨床的個体群からのヨーロッパ系の70,017人の参加者の二の以前の研究を分析した。28,328参加者の複製メタ分析を行った。一塩基多型(SNP)ベースの遺伝率と遺伝相関は,連鎖不平衡スコア回帰を用いて計算した。発見と複製分析はp値ベースメタ分析を用いて行った。生涯大うつ病性障害と抑うつ症状スコアは転帰尺度として用いた。大うつ病性障害のSNP-ベース遺伝率は0.21(SE=0.02)であり,抑うつ症状のSNP-ベース遺伝率は0.04(SE=0.01)であり,それらの遺伝相関は1.001であった(SE=0.2)。FHIT遺伝子のイントロンに位置する広い抑制表現型(rs9825823,染色体361,082,153p=8.2×10~ 9)に関連した一つのゲノムワイド有意な遺伝子座を発見した。独立試料(p=.02)と発見と複製コホートの全体的メタ分析(1.0 × 10~ 9)におけるこのSNPを再現した。大規模研究はうつ病の新規遺伝子座を同定した。著者らの結果は,抑うつ症状および大うつ病性障害の間の連続性を支持する。表現型より包括的なアプローチは,うつ病の感受性遺伝子座を検出するのに必要な大きなサンプルサイズを達成するのに役立つ可能性がある。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *メタ分析 ,  イントロン ,  遺伝相関 ,  ゲノムワイド関連解析 ,  遺伝学 ,  母集団 ,  *うつ病 ,  一塩基多型 ,  個体群 ,  *表現型 ,  遺伝率 ,  ヨーロッパ
準シソーラス用語： 連鎖不平衡 ,  抑欝症状 ,  大欝病性障害 , 【Automatic Indexing@JST】

著者キーワード (6件)： CHARGEコンソーシアム ,  抑うつ症状 ,  FHIT遺伝子 ,  ゲノムワイド関連研究 ,  大うつ病性障害 ,  精神ゲノミクスコンソーシアム

分類 (1件)： 精神科の臨床医学一般  (GR01030T)

タイトルに関連する用語 (7件)： ゲノム ,  解析 ,  うつ病 ,  表現型 ,  遺伝子座 ,  同定 ,  メタ分析