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J-GLOBAL ID：201702279632146260   整理番号：17A0317144

ヒト骨,心臓,および他の中はい葉細胞型への多能性からの対選択をマッピング【Powered by NICT】

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

著者 (24件)： Loh Kyle M. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Chen Angela (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Koh Pang Wei (Departments of Genetics and Computer Science, Stanford University School of Medicine, CA 94305, USA) ,  Deng Tianda Z. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Sinha Rahul (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Tsai Jonathan M. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Barkal Amira A. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Shen Kimberle Y. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Jain Rajan (Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Morganti Rachel M. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Shyh-Chang Ng (Stem Cell & Regenerative Biology Group, Genome Institute of Singapore, Singapore 138672, Singapore) ,  Fernhoff Nathaniel B. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  George Benson M. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Wernig Gerlinde (Department of Pathology, Stanford University School of Medicine, CA 94305, USA) ,  Salomon Rachel E.A. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Chen Zhenghao (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Vogel Hannes (Department of Pathology, Stanford University School of Medicine, CA 94305, USA) ,  Epstein Jonathan A. (Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Kundaje Anshul (Departments of Genetics and Computer Science, Stanford University School of Medicine, CA 94305, USA) ,  Talbot William S. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Beachy Philip A. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA) ,  Beachy Philip A. (Department of Biochemistry, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305, USA) ,  Ang Lay Teng (Stem Cell & Regenerative Biology Group, Genome Institute of Singapore, Singapore 138672, Singapore) ,  Weissman Irving L. (Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Ludwig Center for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, CA 94305, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 166  号： 2  ページ： 451-467  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 望ましい系統への幹細胞分化は,しばしば望ましくない細胞型をもたらすナビゲーション交互発生経路を必要とする。包括的発生ロードマップは所望の運命に向けて幹細胞分化に影響を及ぼすために重要である。この目的のために,ここでは,多能性12種のヒト中胚葉系統にから分岐系統選択,骨,筋肉,心臓を含むを地図化した。を各二元系列決定を制御し,論理的に不要な運命への分化を阻害し,最も分岐点で80%~ 99%純粋なヒト中胚葉系統への多能性幹細胞を迅速に操作することを可能にする外因性シグナルを明らかにした。この戦略は,それぞれのin vivoモデルにおいて生着できることをヒト骨および心臓前駆細胞の生成を可能にした。中胚葉発生におけるマッピング段階的クロマチンと単一細胞遺伝子発現変化は,体節分節化を明らかにし,H OPX発現により一時的に著明な以前に観測できないヒト胚性事象。まとめると,このロードマップは,中胚葉発生のナビゲーションを可能にする移植可能なヒト組織前駆細胞を産生し,発生過程を明らかにする。ヌル表示省略Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 多能性幹細胞 ,  *心臓 ,  *中胚葉 ,  セグメンテーション ,  *ヒト ,  クロマチン ,  *汎用性 ,  前駆細胞 ,  単一細胞 ,  心臓前駆細胞 ,  移植片生着 ,  分岐点 ,  幹細胞分化 ,  *細胞型 ,  道路地図
準シソーラス用語： ロードマップ , 【Automatic Indexing@JST】

分類 (3件)： 細胞生理一般  (EF02010S) ,  発生と分化  (EJ16020W) ,  生物学的機能  (EB03040U)

タイトルに関連する用語 (6件)： ヒト ,  心臓 ,  中はい葉 ,  細胞型 ,  多能性 ,  マッピング