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J-GLOBAL ID：201702297476605497   整理番号：17A1414842

糖尿病と心疾患:2型糖尿病の新規感受性座位の同定ならびに冠動脈性心疾患との共通病因経路

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

著者 (113件)： ZHAO Wei (Univ. Pennsylvania, Pennsylvania, USA) ,  SALEHEEN Danish (Univ. Pennsylvania, Pennsylvania, USA) ,  LEE Jung-Jin (Univ. Pennsylvania, Pennsylvania, USA) ,  TRINDADE Kevin (Univ. Pennsylvania, Pennsylvania, USA) ,  RADER Daniel J (Univ. Pennsylvania, Pennsylvania, USA) ,  RASHEED Asif (Center for Non-Communicable Diseases, Karachi, PAK) ,  SHAH Nabi (Center for Non-Communicable Diseases, Karachi, PAK) ,  JABEEN Sehrish (Center for Non-Communicable Diseases, Karachi, PAK) ,  IMRAN Atif (Center for Non-Communicable Diseases, Karachi, PAK) ,  MAJEED Faisal (Center for Non-Communicable Diseases, Karachi, PAK) ,  FROSSARD Philippe (Center for Non-Communicable Diseases, Karachi, PAK) ,  SALEHEEN Danish (Center for Non-Communicable Diseases, Karachi, PAK) ,  TIKKANEN Emmi (Univ. Helsinki, Helsinki, FIN) ,  RIPATTI Samuli (Univ. Helsinki, Helsinki, FIN) ,  BUTTERWORTH Adam S (Univ. Cambridge, Cambridge, GBR) ,  HOWSON Joanna M M (Univ. Cambridge, Cambridge, GBR) ,  CHOWDHURY Rajiv (Univ. Cambridge, Cambridge, GBR) ,  SURENDRAN Praveen (Univ. Cambridge, Cambridge, GBR) ,  DI ANGELANTONIO Emanuele (Univ. Cambridge, Cambridge, GBR) ,  YOUNG Robin (Univ. Cambridge, Cambridge, GBR) ,  DANESH John (Univ. Cambridge, Cambridge, GBR) ,  ASSIMES Themistocles L (Stanford Univ. School of Medicine, California, USA) ,  QUERTERMOUS Thomas (Stanford Univ. School of Medicine, California, USA) ,  ORHO-MELANDER Marju (Lund Univ., Malmoe, SWE) ,  MELANDER Olle (Lund Univ., Malmoe, SWE) ,  DAMRAUER Scott (Univ. Pennsylvania, Pennsylvania, USA) ,  SMALL Aeron (Univ. Pennsylvania, Pennsylvania, USA) ,  VOIGHT Benjamin F (Univ. Pennsylvania, Pennsylvania, USA) ,  ASMA Senay (McMaster Univ., Ontario, CAN) ,  IMAMURA Minako (RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  MAEDA Shiro (RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  IMAMURA Minako (Univ. the Ryukyus, Nishihara, JPN) ,  MAEDA Shiro (Univ. the Ryukyus, Nishihara, JPN) ,  YAMAUCH Toshimasa (Univ. Tokyo, Tokyo, JPN) ,  KADOWAKI Takashi (Univ. Tokyo, Tokyo, JPN) ,  CHAMBERS John C (Imperial Coll. London, London, GBR) ,  ZHANG Weihua (Imperial Coll. London, London, GBR) ,  KOONER Jaspal S (Imperial Coll. London, London, GBR) ,  CHAMBERS John C (Ealing Hospital NHS Trust, Southall, GBR) ,  ZHANG Weihua (Ealing Hospital NHS Trust, Southall, GBR) ,  CHAMBERS John C (Imperial Coll. Healthcare NHS Trust, London, GBR) ,  KOONER Jaspal S (Imperial Coll. Healthcare NHS Trust, London, GBR) ,  CHEN Peng (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  TEO Yik Ying (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  SAPKOTA Bishwa R (Univ. Oklahoma Health Sci. Center, Oklahoma, USA) ,  SANGHERA Dharambir K (Univ. Oklahoma Health Sci. Center, Oklahoma, USA) ,  SHAH Nabi (COMSATS Inst. of Information Technol., Abbottabad, PAK) ,  LU Yingchang (Icahn School of Medicine at Mount Sinai, New York, USA) ,  BOTTINGER Erwin P (Icahn School of Medicine at Mount Sinai, New York, USA) ,  LOOS Ruth J F (Icahn School of Medicine at Mount Sinai, New York, USA) ,  LU Yingchang (Vanderbilt Univ. School of Medicine, Tennessee, USA) ,  LOOS Ruth J F (Vanderbilt Univ. School of Medicine, Tennessee, USA) ,  ABBAS Shahid (Faisalabad Inst. of Cardiology, Faisalabad, PAK) ,  QAMAR Nadeem (National Inst. of Cardiovascular Disorders, Karachi, PAK) ,  YAQOOB Zia (National Inst. of Cardiovascular Disorders, Karachi, PAK) ,  SAGHIR Tahir (National Inst. of Cardiovascular Disorders, Karachi, PAK) ,  RIZVI Syed Nadeem Hasan (National Inst. of Cardiovascular Disorders, Karachi, PAK) ,  MEMON Anis (National Inst. of Cardiovascular Disorders, Karachi, PAK) ,  MALLICK Nadeem Hayyat (Punjab Inst. of Cardiology, Lahore, PAK) ,  RASHEED Syed Zahed (Karachi Inst. of Heart Diseases, Karachi, PAK) ,  MEMON Fazal-ur-Rehman (Red Crescent Inst. of Cardiology, Hyderabad, PAK) ,  MEHMOOD Khalid (Civil Hospital, Karachi, PAK) ,  AHMED Naveeduddin (Liaquat National Hospital, Karachi, PAK) ,  QURESHI Irshad Hussain (Mayo Hospital and King Edward Medical Univ., Lahore, PAK) ,  MALIK Uzma (Mayo Hospital and King Edward Medical Univ., Lahore, PAK) ,  TANVEER-US-SALAM (Lahore General Hospital, Lahore, PAK) ,  IQBAL Wasim (Lahore General Hospital, Lahore, PAK) ,  MEHRA Narinder (All-India Inst. of Medical Sci., New Delhi, IND) ,  KUO Jane Z (CardioDx, Inc., California, USA) ,  KUO Jane Z (Medical Center, Harbor-UCLA, California, USA) ,  GUO Xiuqing (Medical Center, Harbor-UCLA, California, USA) ,  TAYLOR Kent D (Medical Center, Harbor-UCLA, California, USA) ,  ROTTER Jerome I (Medical Center, Harbor-UCLA, California, USA) ,  CHEN Yii-Der Ida (Medical Center, Harbor-UCLA, California, USA) ,  SHEU Wayne H-H (Taichung Veterans General Hospital, Taichung, TWN) ,  LEE I-Te (Taichung Veterans General Hospital, Taichung, TWN) ,  SHEU Wayne H-H ,  LEE I-Te ,  HSIUNG Chao A (National Health Res. Inst., Miaoli, TWN) ,  HSU Chih-Cheng (National Health Res. Inst., Miaoli, TWN) ,  CHUNG Ren-Hua (National Health Res. Inst., Miaoli, TWN) ,  JUANG Jyh-Ming J (National Taiwan Univ. Coll. of Medicine, Taipei, TWN) ,  WANG Tzung-Dau (National Taiwan Univ. Coll. of Medicine, Taipei, TWN) ,  HUNG Yi-Jen (National Defense Medical Center, Taipei, TWN) ,  LEE Wen-Jane (Taichung Veterans General Hospital, Taichung, TWN) ,  RALHAN Sarju (Hero DMC Heart Inst. Punjab, IND) ,  TEO Yik Ying (A*STAR, Singapore) ,  TEO Yik Ying (Singapore National Eye Centre, Singapore) ,  TEO Yik Ying (National Univ. Singapore, Singapore) ,  ALAM Dewan S (International Centre for Diarrhoeal Disease Res., Dhaka, BGD) ,  EPSTEIN Steve (MedStar Washington Hospital Center, Washington, DC, USA) ,  NIELSEN Sune F (Frederiksberg Hospital, Frederiksberg, DNK) ,  NORDESTGAARD Borge G (Copenhagen Univ. Hospital, Herlev, DNK) ,  TYBJAERG-HANSEN Anne (Copenhagen Univ. Hospital, Herlev, DNK) ,  KAMSTRUP Pia R (Copenhagen Univ. Hospital, Herlev, DNK) ,  NORDESTGAARD Borge G (Univ. Copenhagen, Copenhagen, DNK) ,  TYBJAERG-HANSEN Anne (Copenhagen Univ. Hospital, Copenhagen, DNK) ,  FRIKKE-SCHMIDT Ruth (Copenhagen Univ. Hospital, Copenhagen, DNK) ,  BENN Marianne (Leiden Univ. Medical Center, Leiden, NLD) ,  JUKEMA J Wouter (Leiden Univ. Medical Center, Leiden, NLD) ,  JUKEMA J Wouter (Interuniversity Cardiology Inst. of the Netherlands, Utrecht, NLD) ,  SATTAR Naveed (Univ. Glasgow, Glasgow, GBR) ,  SMIT Roelof (Leiden Univ. Medical Center, Leiden, NLD) ,  LIANG Kae-Woei (Taichung Veterans General Hospital, Taichung, TWN) ,  ANAND Sonia (McMaster Univ., Ontario, CAN) ,  SANGHERA Dharambir K (Oklahoma Center for Neuroscience, Oklahoma, USA) ,  RIPATTI Samuli (National Inst. for Health and Welfare, Helsinki, FIN) ,  SALOMAA Veikko (National Inst. for Health and Welfare, Helsinki, FIN) ,  RIPATTI Samuli (Wellcome Trust Sanger Inst., Hinxton, GBR) ,  TAI E Shyong (National Univ. Singapore, Singapore) ,  REILLY Muredach (Columbia Univ., New York, USA) ,  PARE Guillaume (McMaster Univ., Ontario, CAN) ,  DANESH John (Wellcome Trust Sanger Inst., Hinxton, GBR)
資料名： Nature Genetics  (Nature Genetics)
巻： 49  号： 10  ページ： 1450-1457  発行年： 2017年10月 
JST資料番号： W0430A  ISSN： 1061-4036  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 2型糖尿病(T2D)と冠動脈性心疾患(CHD)に共通する遺伝的な病因を評価する目的で,複数の祖先集団を対象にした両疾患の遺伝学的多様性に関するゲノムワイドな解析を行った。解析した患者数は,T2Dについては26万5678人,CHDについては26万0365人に上った。その結果,これまでに報告されていない感受性座位が,T2Dについて16個,CHDについては1個同定された。前者には例えば,HLA-DRB5の新規ミスセンスバリアントがある〔オッズ比(OR)=1.29〕。遺伝的要因によるT2Dリスクの上昇は,CHDのリスクも上昇させることが示された。T2DとCHDをまとめて解析した結果,8つのバリアント(そのうち2つはコーディングバリアント)が同定されたが,T2DとCHDの関連は共局在しているようであった。例えば,CCDC92にはT2DとCHDの両方の関連が新たに判明し,T2Dとの関連は再現解析でも確認できた。両疾患との関連を有するバリアントは,新しい病因経路の存在や,イコサペント酸エチルや脂肪細胞型脂肪酸結合タンパク質などの標的の存在を示唆している。Copyright Nature Japan KK 2017

シソーラス用語： *2型糖尿病 ,  遺伝子 ,  *冠動脈疾患 ,  *病因 ,  遺伝学実験技術
準シソーラス用語： *感受性遺伝子 ,  *冠動脈性心疾患 ,  *全ゲノム解析

分類 (2件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  循環系の疾患  (GJ03000C)

タイトルに関連する用語 (9件)： 糖尿病 ,  心疾患 ,  2型糖尿病 ,  感受性 ,  座位 ,  同定 ,  冠動脈性心疾患 ,  病因 ,  経路