2018 - 2019 UDP-グルクロン酸転移酵素 (UGT) の C 末領域による新たな活性制御機構: UGT のオリゴマー化および薬物代謝活性の包括的解析
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論文 (21件):
Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi. Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products. The Journal of toxicological sciences. 2023. 48. 5. 263-272
Madoka Sawai, Yuu Miyauchi, Takumi Ishida, Shinji Takechi. Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of Toxicological Sciences. 2022. 47. 9. 381-387
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I Mackenzie, Yuji Ishii. Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in pharmacology. 2022. 13. 832931-832931
Shoji Nakamura, Ryohei Yamashita, Yuu Miyauchi, Yoshitaka Tanaka, Yuji Ishii. Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems. 2021. 51. 11. 1-25
Hong-Bin Chen, Jorge Carlos Pineda Garcia, Shinako Arizono, Tomoki Takeda, Ren-Shi Li, Yukiko Hattori, Hiroe Sano, Yuu Miyauchi, Yuko Hirota, Yoshitaka Tanaka, et al. DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports. 2021. 11. 1. 18532-18532
Yuu Miyauchi, Shinji Takechi, Yuji Ishii. Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin. 2021. 44. 11. 1635-1644
Investigation of the function of UDP-glucuronosyltransferase focusing on its enzymatic features: C-terminal cytoplasmic peptide and oligomer formation
(PRIS 2023 in 2023 ICCP450/JSSX International Joint Meeting (Educational Lecture) 2023)
Functional interactions between different drug-metabolizing enzymes: a novel approach for variance in CYP3A4 activity
(日本薬物動態学会第37回年会(受賞講演) 2022)