久保智広

Kubo Tomohiro

所属機関・部署：
職名：講師

研究分野 (2件)：生物物理学 , 細胞生物学

研究キーワード (7件)：ポリグルタミン酸化 , 翻訳後修飾 , チューブリン , ダイニン , クラミドモナス , 繊毛 , 鞭毛

競争的資金等の研究課題 (10件)：

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論文 (21件)：

Tomohiro Kubo, Rinka Sasaki, Toshiyuki Oda. Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins. Molecular Biology of the Cell. 2024
Tomohiro Kubo, Yuma Tani, Haru-Aki Yanagisawa, Masahide Kikkawa, Toshiyuki Oda. α- and β-tubulin C-terminal tails with distinct modifications are crucial for ciliary motility and assembly. Journal of Cell Science. 2023
Tomohiro Kubo, Natsumi Kanou, Toshiyuki Oda. Puromycin is incorporated into regenerating flagella of Chlamydomonas reinhardtii as an indicator of nascent flagellar proteins. bioRxiv. 2022
Yuqing Hou, Lei Zhao, Tomohiro Kubo, Xi Cheng, Nathan McNeill, Toshiyuki Oda, George B. Witman. Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a. Journal of Cell Science. 2021
Julie Craft Van De Weghe, J. Aaron Harris, Tomohiro Kubo, George B. Witman, Karl F. Lechtreck. Diffusion rather than IFT likely provides most of the tubulin required for axonemal assembly. Journal of Cell Science. 2020. jcs.249805-jcs.249805

MISC (2件)：

T. Kubo, M. Hirono, T. Aikawa, G. B. Witman, R. Kamiya. A suppressor mutant, ssh1, of flagellar shortness in dynein-deficient Chlamydomonas strains is deficient in the gene encoding FAP234, a protein involved in tubulin polyglutamylation. MOLECULAR BIOLOGY OF THE CELL. 2013. 24
T. Kubo, H-A. Yanagisawa, Z. Liu, R. Shibuya, M. Hirono, R. Kamiya. A novel Chlamydomonas mutant, tpg2, reveals a conserved 177-kDa protein crucial for the localization of TTLL9, an enzyme that catalyzes tubulin polyglutamylation in the axoneme. MOLECULAR BIOLOGY OF THE CELL. 2012. 23

講演・口頭発表等 (41件)：

チューブリングリシル化による繊毛運動の調節機構
(第76回日本細胞生物学会 2024)
クラミドモナスの鞭毛内で見つかった蛋白質合成系の解明
(第13回繊毛研究会 2023)
Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
(第49回内藤コンファレンス 2023)
単細胞緑藻類クラミドモナスの繊毛で新規に見つかった蛋白質合成系の解明
(第75 回日本細胞生物学会 2023)
Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
(20th International Conference on the Cell and Molecular Biology of Chlamydomonas 2023)

学歴 (4件)：

学位 (1件)：

経歴 (7件)：

2020/08 - 現在法政大学理工学研究科生命機能学専攻非常勤講師
2019/04 - 現在山梨大学医学部解剖学講座構造生物学教室講師
2016/04 - 2019/03 山梨大学医学部解剖学講座構造生物学教室特任助教
2014/04 - 2016/03 University of Massachusetts Medical School Cell and Developmental Biology Postdoctoral Research Associate
2013/04 - 2014/03 University of Massachusetts Medical School Cell and Developmental Biology Postdoctoral Research Associate (Founded by Uehara Memorial Foundation)

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受賞 (3件)：

2023/07 - 公益財団法人内藤科学振興財団 Poster Award for Excellence Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
2014/06 - 16th International Conference on the Cell and Molecular Biology of Chlamydomonas. 1st place Poster award
2012/06 - 16th International Conference on the Cell and Molecular Biology of Chlamydomonas. 3rd place Poster award

所属学会 (3件)：

日本生物物理学会 , 日本動物学会 , 日本細胞生物学会

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久保 智広