研究者
J-GLOBAL ID：201801017326585350
更新日: 2024年03月21日
上原 正太郎
ウエハラ ショウタロウ | Shotaro Uehara
所属機関・部署：
職名：
研究員
その他の所属（所属・部署名・職名） (1件)：
研究キーワード (4件)：
マーモセット
, ヒト肝キメラマウス
, チトクロムP450
, 薬物代謝
競争的資金等の研究課題 (3件)：
- 2020 - 2023 新規の肝臓ヒト化薬物性肝障害モデルマウスによるヒト特異的薬物肝毒性の発現機序解明
- 2017 - 2019 非ヒト霊長類および実験動物チトクロムP450の生化学的比較解析
- 2015 - 2017 マーモセット薬物代謝酵素チトクロムP450 2C分子種の機能および多型性解析
論文 (114件)：
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Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Miki Nakajima. Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation. Drug Metabolism and Pharmacokinetics. 2024. 101007-101007
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Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani, Hiroshi Yamazaki. Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver. Xenobiotica; the fate of foreign compounds in biological systems. 2023. 1-6
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Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki. Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolitesin Pediatric Patients Genotyped for CytochromeP450 2D6. Drug Metabolism and Disposition. 2023. DMD-AR
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Shotaro Uehara, Masahiko Yasuda, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masami Suzuki, Hiroshi Yamazaki, Hiroshi Suemizu. SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. Toxicology letters. 2023. 388. 48-55
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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi, Norie Murayama, Hiroshi Yamazaki, Kazuhiro Murai, Hayato Hikita, Tetsuo Takehara, et al. HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. Biochemical and biophysical research communications. 2023. 663. 132-141
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MISC (13件)：
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Yasuhiro Uno, Shotaro Uehara, Hiroshi Yamazaki. Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans. Biochemical Pharmacology. 2022. 197
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Kazuhide Iwasaki, Yusuke Kitsugi, Kanami Ikeda, Takahiro Yoshikawa, Shotaro Uehara, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki. EFFECT OF CYP2C9 GENOTYPE FOR PHARMACOKINETICS OF EFAVIRENZ IN VIVO IN CYNOMOLGUS MONKEYS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S39-S39
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Shotaro Uehara, Yasuhiro Uno, Yukako Yuki, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki. IDENTIFICATION AND CHARACTERIZATION OF CYTOCHROME P450 4F ENZYMES IN MARMOSETS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S40-S40
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Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, Erika Sasaki. Cytochrome P450-dependent warfarin and caffeine metabolism in marmosets, monkeys, and humans. DRUG METABOLISM REVIEWS. 2016. 48. 38-39
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Shotaro Uehara, Makiko Shimizu, Norie Murayama, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki. OXIDATIVE METABOLISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) BY LIVER AND BRAIN MICROSOMES FROM COMMON MARMOSETS. DRUG METABOLISM REVIEWS. 2015. 47. 73-74
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特許 (4件)：
学歴 (1件)：
学位 (1件)：
経歴 (3件)：
- 2017/04 - 現在 公益財団法人実験動物中央研究所 実験動物研究部 研究員
- 2014/04 - 2017/03 昭和薬科大学 薬物動態学研究室 特任助教
- 2007/04 - 2014/03 株式会社新日本科学 研究員
所属学会 (3件)：
日本実験動物学会
, International Society of Study of Xenobiotics
, 日本薬物動態学会
