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J-GLOBAL ID：201802211096607384   整理番号：18A0397134

ヒト癌における高頻度変異の包括的解析【Powered by NICT】

Comprehensive Analysis of Hypermutation in Human Cancer

著者 (87件)： Campbell Brittany B. (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Campbell Brittany B. (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada) ,  Campbell Brittany B. (Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada) ,  Light Nicholas (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Light Nicholas (Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada) ,  Fabrizio David (Foundation Medicine, Inc., Cambridge, MA, USA) ,  Zatzman Matthew (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Zatzman Matthew (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada) ,  Fuligni Fabio (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  de Borja Richard (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Davidson Scott (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Davidson Scott (Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada) ,  Edwards Melissa (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Elvin Julia A. (Foundation Medicine, Inc., Cambridge, MA, USA) ,  Hodel Karl P. (Department of Biochemistry and Molecular Biology, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA) ,  Zahurancik Walter J. (The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA) ,  Zahurancik Walter J. (Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA) ,  Suo Zucai (The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA) ,  Suo Zucai (Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA) ,  Lipman Tatiana (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Wimmer Katharina (Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria) ,  Kratz Christian P. (Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany) ,  Bowers Daniel C. (Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Bowers Daniel C. (Pauline Allen Gill Center for Cancer and Blood Disorders, Children’s Health, Dallas, TX, USA) ,  Laetsch Theodore W. (Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Laetsch Theodore W. (Pauline Allen Gill Center for Cancer and Blood Disorders, Children’s Health, Dallas, TX, USA) ,  Dunn Gavin P. (Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA) ,  Johanns Tanner M. (Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA) ,  Johanns Tanner M. (Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA) ,  Grimmer Matthew R. (Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA) ,  Smirnov Ivan V. (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA) ,  Smirnov Ivan V. (Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA) ,  Larouche Valerie (Department of Pediatrics, Centre Mere-enfant Soleil du CHU de Quebec, CRCHU de Quebec, Universite Laval, Quebec City, QC, Canada) ,  Samuel David (Department of Hematology-Oncology, Valley Children’s Hospital, Madera, CA, USA) ,  Bronsema Annika (Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Osborn Michael (Department of Haematology and Oncology, Women’s and Children’s Hospital, North Adelaide, SA, Australia) ,  Stearns Duncan (Department of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children’s Hospital, Cleveland, OH, USA) ,  Raman Pichai (Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  Raman Pichai (Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) ,  Cole Kristina A. (Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  Cole Kristina A. (Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) ,  Storm Phillip B. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  Yalon Michal (Department of Pediatric Hematology-Oncology, Sheba Medical Center, Tel Hashomer, Israel) ,  Opocher Enrico (Pediatric Oncology & Hematology, Azienda Ospedaliera-Universita degli Studi di Padova, Via Giustiniani n.1, Padova, Italy) ,  Mason Gary (Department of Pediatric Hematology-Oncology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA) ,  Thomas Gregory A. (Division of Pediatric Hematology-Oncology, Oregon Health & Science University, Portland, OR, USA) ,  Sabel Magnus (Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg & Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden) ,  George Ben (Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA) ,  Ziegler David S. (Kids Cancer Centre, Sydney Children’s Hospital, Randwick, NSW, Australia) ,  Ziegler David S. (Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia) ,  Lindhorst Scott (Neuro-Oncology, Department of Neurosurgery, and Department of Medicine, Division of Hematology/Medical Oncology, Medical University of South Carolina, Charleston, SC, USA) ,  Issai Vanan Magimairajan (Department of Pediatric Hematology-Oncology, Cancer Care Manitoba; Research Institute in Oncology and Hematology (RIOH), University of Manitoba, Winnipeg, MB, Canada) ,  Constantini Shlomi (Department of Pediatric Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel) ,  Toledano Helen (Department of Pediatric Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel) ,  Elhasid Ronit (Department of Hematology-Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel) ,  Farah Roula (Department of Pediatrics, Saint George Hospital University Medical Center, Beirut, Lebanon) ,  Dvir Rina (Department of Pediatric Hematology/Oncology, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel) ,  Dvir Rina (Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel) ,  Dirks Peter (Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada) ,  Huang Annie (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada) ,  Huang Annie (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Huang Annie (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada) ,  Galati Melissa A. (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Chung Jiil (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Ramaswamy Vijay (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Irwin Meredith S. (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Aronson Melyssa (Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada) ,  Durno Carol (Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada) ,  Durno Carol (Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada) ,  Taylor Michael D. (Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada) ,  Rechavi Gideon (Cancer Research Center and Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel) ,  Maris John M. (Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  Maris John M. (Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) ,  Bouffet Eric (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Hawkins Cynthia (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada) ,  Costello Joseph F. (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA) ,  Meyn M. Stephen (Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada) ,  Meyn M. Stephen (Center for Human Genomics and Precision Medicine, University of Wisconsin, Madison, WI, USA) ,  Pursell Zachary F. (Department of Biochemistry and Molecular Biology, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA) ,  Malkin David (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Malkin David (Department of Pediatrics, University of Toronto, Toronto, ON, Canada) ,  Tabori Uri (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Tabori Uri (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada) ,  Tabori Uri (Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Shlien Adam (Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada) ,  Shlien Adam (Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada) ,  Shlien Adam (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 171  号： 5  ページ： 1042-1056.e10  発行年： 2017年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 小児および成人患者から>81,000腫瘍の配列分析による変異負荷の広範な評価,化学療法,発癌物質,または生殖細胞変異による超変異を有する腫瘍を示した。超変異は高い変異負荷と以前関連していない腫瘍型で検出された。複製修復欠損は主要な寄与因子であった。複製修復関連DNAポリメラーゼの新しいドライバー変異と変異負荷のスケールでのマイクロサテライト不安定性と複製修復欠損の明確な影響を明らかにした。変異文脈に基づいて,不偏クラスタ化は,起源の腫瘍組織に関係なく臨床的に関連したサブグループを明らかにし,超変異をもたらす進化的動力学における類似性を強調した。,UV光のような変異原は予想外の癌肉腫と肺腫瘍などに関係していた。変異シグネチャの順序は前処理と生殖系列複製修復欠損,患者・家族の管理を改善することを同定した。これらのデータは,腫瘍の分類,遺伝的試験および臨床試験設計に有用である。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 類似性 ,  薬物療法 ,  肺腫瘍 ,  DNAポリメラーゼ ,  子供 ,  *ヒト ,  患者 ,  成人 ,  クラスタ化 ,  腫瘍 ,  遺伝 ,  紫外線 ,  発癌物質 ,  *変異
準シソーラス用語： マイクロサテライト不安定性 , 【Automatic Indexing@JST】

著者キーワード (8件)： hypermutation ,  ミューテータ ,  癌ゲノミクス ,  免疫チェックポイント阻害剤 ,  ミスマッチ修復 ,  DNA複製 ,  DNA修復 ,  癌素因

分類 (2件)： 分子遺伝学一般  (EC02010J) ,  発癌機序・因子  (GE02020C)

タイトルに関連する用語 (4件)： ヒト ,  癌 ,  高頻度変異 ,  解析