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J-GLOBAL ID：201802211332949736   整理番号：18A1295357

炎症誘発性の有害妊娠と新生児転帰は免疫調節ペプチドExendin-4により改善されることができる【JST・京大機械翻訳】

Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4

著者 (39件)： Garcia-Flores Valeria (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Garcia-Flores Valeria (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Garcia-Flores Valeria (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Garcia-Flores Valeria (Departamento de Genetica y Biologia Molecular, Cinvestav) ,  Romero Roberto (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Romero Roberto (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Romero Roberto (Department of Obstetrics and Gynecology, University of Michigan) ,  Romero Roberto (Department of Epidemiology and Biostatistics, Michigan State University) ,  Romero Roberto (Center for Molecular Medicine and Genetics, Wayne State University) ,  Miller Derek (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Miller Derek (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Miller Derek (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Miller Derek (Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine) ,  Xu Yi (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Xu Yi (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Xu Yi (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Done Bogdan (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Done Bogdan (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Done Bogdan (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Veerapaneni Chharitha (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Leng Yaozhu (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Leng Yaozhu (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Leng Yaozhu (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Arenas-Hernandez Marcia (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Arenas-Hernandez Marcia (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Arenas-Hernandez Marcia (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Arenas-Hernandez Marcia (Departamento de Biomedicina Molecular, Cinvestav) ,  Khan Nabila (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Panaitescu Bogdan (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Panaitescu Bogdan (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Panaitescu Bogdan (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Hassan Sonia S. (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Hassan Sonia S. (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Hassan Sonia S. (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Alvarez-Salas Luis Marat (Departamento de Genetica y Biologia Molecular, Cinvestav) ,  Gomez-Lopez Nardhy (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Gomez-Lopez Nardhy (Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD/NIH/DHHS) ,  Gomez-Lopez Nardhy (Department of Obstetrics and Gynecology, Wayne State University School of Medicine) ,  Gomez-Lopez Nardhy (Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine)
資料名： Frontiers in Immunology (Web)  (Frontiers in Immunology (Web))
巻： 9  ページ： 1291  発行年： 2018年 
JST資料番号： U7074A  ISSN： 1664-3224  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 早産は,世界中の新生児罹患率と死亡率の主要な原因である。炎症は通常早産と関連する。したがって,母親と胎児の炎症反応を弱める介入を見出すことは,妊娠と新生児の副作用を予防するための新しい戦略を提供する可能性がある。全身性母体炎症の動物モデル(リポ多糖類(LPS)の腹腔内投与)と胎児炎症(LPSの羊膜内投与)を用いて,(1)全身性炎症が重篤な母親のサイトカイン嵐と軽度の胎児サイトカイン応答を引き起こすことにより,有害妊娠と新生児の転帰を誘導することを見出した。(2)胎児炎症は,軽度の母親のサイトカイン反応と重篤な胎児のサイトカイン嵐を引き起こすことによって,妊娠と新生児の結果を誘発した。(3)全身性炎症または胎児炎症によるダムのエキセンジン-4(Ex4)処置は,早産の比率を穏やかに減少することによって,有害妊娠結果を改善した。(4)全身性ではあるが局所的ではない母親のex4治療は新生児の転帰をかなり改善し,そのような新生児は増殖を続けた;(5)全身性炎症は,子宮と母性-胎児界面を通して,Ex4の拡散を促進した。(6)全身性炎症を伴うEx4処理ダムに生まれた新生児は,健常対照新生児に類似のサイトカインプロファイルを示した;(7)ex4による治療は,全身性炎症を有する母親に生まれた新生児におけるCD8+調節性T細胞の拡大を抑制するだけでなく,M2マクロファージ分極を誘導し,抗炎症性好中球を増加させることによって免疫調節効果を有した。まとめると,これらの結果は,ex4のような新しい介入による母親の全身性炎症の減衰が,この臨床状態を有する女性に生まれた新生児のクオリティオブライフを改善できるという証拠を提供する。Copyright 2018 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： クオリティオブライフ ,  リポ多糖類 ,  *新生児 ,  *妊娠 ,  *炎症 ,  死亡率 ,  好中球 ,  消炎作用 ,  サイトカイン ,  女性 ,  *ペプチド ,  胎児 ,  子宮 ,  治療法
準シソーラス用語： 炎症反応 , 【Automatic Indexing@JST】

著者キーワード (8件)： 羊水 ,  臨床絨毛羊膜炎 ,  胎児炎症反応症候群 ,  羊膜内感染/炎症 ,  M2マクロファージ ,  好中球 ,  調節性T細胞 ,  早産と出産

分類 (2件)： 婦人科疾患,妊産婦の疾患  (GS03000D) ,  神経の基礎医学  (GN01020W)

タイトルに関連する用語 (4件)： 炎症 ,  妊娠 ,  新生児転帰 ,  免疫調節