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J-GLOBAL ID：201802222665328202   整理番号：18A0797657

CD36遺伝子変異体は,農村中国人成人における肥満の相互作用を介して2型糖尿病と関連する【JST・京大機械翻訳】

CD36 gene variants is associated with type 2 diabetes mellitus through the interaction of obesity in rural Chinese adults

著者 (38件)： Zhang Dongdong (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Dongdong (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Dongdong (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ruiyuan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ruiyuan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Yu (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Sun Xizhuo (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Yin Zhaoxia (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Li Honghui (The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhao Yang (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhao Yang (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Wang Bingyuan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Wang Bingyuan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Ren Yongcheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Ren Yongcheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Cheng Cheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Cheng Cheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Xuejiao (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Xuejiao (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Dechen (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Dechen (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Feiyan (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Feiyan (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Chen Xu (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Chen Xu (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Leilei (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Leilei (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhou Qionggui (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhou Qionggui (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Xiong Yihan (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Xu Qihuan (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Liu Jiali (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hong Shihao (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  You Ziyang (Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hu Dongsheng (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Hu Dongsheng (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ming (Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China) ,  Zhang Ming (Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China)
資料名： Gene  (Gene)
巻： 659  ページ： 155-159  発行年： 2018年 
JST資料番号： E0701B  ISSN： 0378-1119  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 証拠は,クラスター決定因子36(CD36)蛋白質が脂質代謝とインシュリン抵抗性に役割を果たし,CD36の発現が肥満で誘導されることを示す。本研究では,2型糖尿病(T2DM)リスクに対するCD36変異体の関連と肥満との相互作用を評価した。著者らは,中国の中国コホート研究に入れられた症例対照研究を実施した。著者らは,性別,年齢(2歳以内),結婚状態,および居住村によって,1:1の比率で非T2DM対照とマッチした546人の入射ントT2DM症例を含んだ。CD36における4つの遺伝子座(rs1194197,rs2151916,rs3211956およびrs7755)を,SNPscan-TM遺伝子タイピングシステムによって遺伝子型決定した。潜在的交絡を調整した後に,CD36多型とT2DMリスクの間に統計的に有意な関連性を観察しなかった。正常体重の野生型ホモ接合キャリアと比較して,変異対立遺伝子rs7755を持つ過体重/肥満参加者はT2DMのリスク増加を示し,変異対立遺伝子rs7755を持つ腹部肥満参加者はT2DMのリスク増加を示し,133%(OR=2.33,95%CI:1.48~3.66;P_相互作用=0.002)であった。さらに,rs2151916多型はトリグリセリドレベル(P=0.019)と関連し,rs1194197変異体は対照群内の収縮期血圧(P=0.023)に関連した。CD36遺伝子型は,独立してT2DMへの進行と関連しなかった。しかし,著者らの結果は,CD36変異体とT2DM感受性の肥満の間の正の相互作用を示唆し,それは心臓代謝障害を介している可能性がある。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *2型糖尿病 ,  タンパク質 ,  コホート研究 ,  *中華人民共和国 ,  体重 ,  遺伝子型 ,  *成人 ,  対立遺伝子 ,  *肥満 ,  インスリン抵抗性 ,  *相互作用 ,  感受性 ,  症例対照研究
準シソーラス用語： *中国人 ,  *CD36抗原 , 【Automatic Indexing@JST】

著者キーワード (4件)： CD36 ,  多形 ,  肥満 ,  2型糖尿病

分類 (2件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  遺伝的変異  (EC01030Y)

タイトルに関連する用語 (9件)： CD36 ,  遺伝子 ,  変異体 ,  農村 ,  中国人 ,  成人 ,  肥満 ,  相互作用 ,  2型糖尿病