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J-GLOBAL ID：201802230427073204   整理番号：18A2151315

Tヘルパー細胞サイトカインは腸幹細胞の再生と分化を調節する【JST・京大機械翻訳】

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

著者 (48件)： Biton Moshe (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Biton Moshe (Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Haber Adam L. (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Rogel Noga (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Burgin Grace (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Beyaz Semir (The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA) ,  Beyaz Semir (Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA) ,  Beyaz Semir (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA) ,  Schnell Alexandra (Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Ashenberg Orr (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Su Chien-Wen (Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA) ,  Smillie Christopher (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Shekhar Karthik (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Chen Zuojia (Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Wu Chuan (Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Ordovas-Montanes Jose (Institute for Medical Engineering & Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Ordovas-Montanes Jose (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Ordovas-Montanes Jose (Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA) ,  Ordovas-Montanes Jose (The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02142, USA) ,  Alvarez David (Department of Microbiology & Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA) ,  Herbst Rebecca H. (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Herbst Rebecca H. (Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA) ,  Zhang Mei (Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA) ,  Tirosh Itay (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Tirosh Itay (Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel) ,  Dionne Danielle (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Nguyen Lan T. (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Xifaras Michael E. (The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA) ,  Shalek Alex K. (Institute for Medical Engineering & Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA) ,  Shalek Alex K. (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Shalek Alex K. (Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA) ,  Shalek Alex K. (The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02142, USA) ,  von Andrian Ulrich H. (Department of Microbiology & Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA) ,  Graham Daniel B. (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Rozenblatt-Rosen Orit (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Shi Hai Ning (Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA) ,  Kuchroo Vijay (Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Kuchroo Vijay (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Yilmaz Omer H. (The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA) ,  Yilmaz Omer H. (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Yilmaz Omer H. (Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Regev Aviv (Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Regev Aviv (The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA) ,  Regev Aviv (Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA) ,  Xavier Ramnik J. (Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Xavier Ramnik J. (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Xavier Ramnik J. (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Xavier Ramnik J. (Center for Microbiome informatics and Therapeutics, MIT, Cambridge, MA 02139, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 175  号： 5  ページ： 1307-1320.e22  発行年： 2018年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 小腸において,付属細胞型のニッチは,腸幹細胞(ISC)から成熟上皮細胞型の発生を支持する。しかしながら,ニッチにおける免疫細胞がISC運命に影響を及ぼすか,または自己再生と分化の間のバランスに影響を及ぼすかどうかは不明である。ここでは,単一細胞RNA配列決定(scRNA-seq)を用いて,Lgrr5+ISCsの2つのサブセットにおけるMHCクラスII(MHCII)の機械濃縮を同定した。MHCII+Lgrr5+ISCはCD4+Tヘルパー(Th)細胞との共培養において非従来型抗原提示細胞であることを示した。重要なThサイトカインによる腸の器官の刺激は,対立する方法でLgrr5+ISCの更新と分化に影響を及ぼす:炎症性シグナルは分化を促進するが,調節細胞とサイトカインはそれを減少させる。Th細胞のin vivo遺伝的摂動またはLgrr5+ISC上のMHCII発現は,感染時の上皮細胞分化とIEC運命に影響する。これらの相互作用はTh細胞とLgr5+ISCの間の相互作用により,外部シグナルに対する組織全体の応答を調節する。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 部分集合 ,  共培養 ,  *分化 ,  *幹細胞 ,  炎症 ,  相互作用 ,  上皮細胞 ,  RNA【核酸】 ,  小腸 ,  上皮 ,  *サイトカイン
準シソーラス用語： Lgr5 ,  単一細胞 ,  免疫細胞 ,  ニッチ , 【Automatic Indexing@JST】

著者キーワード (15件)： 腸生物学 ,  腸幹細胞 ,  ISCS ,  Tヘルパー ,  TH ,  粘膜免疫 ,  MHCクラスII ,  MHCII ,  TUFTセル ,  T調節 ,  Treg ,  単一細胞RNA-seq ,  SCRNA-seq ,  上皮分化 ,  幹細胞再生

分類 (1件)： 細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： Tヘルパー細胞 ,  サイトカイン ,  腸幹細胞 ,  分化 ,  調節