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J-GLOBAL ID：201802231038716111   整理番号：18A2103225

ヒトにおけるβ細胞機能,血清代謝物および食欲に対するキスペプチンの効果【JST・京大機械翻訳】

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

著者 (42件)： Izzi-Engbeaya Chioma (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Comninos Alexander N. (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Comninos Alexander N. (Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK) ,  Clarke Sophie A. (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Jomard Anne (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Yang Lisa (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Jones Sophie (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Abbara Ali (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Narayanaswamy Shakunthala (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Eng Pei Chia (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Papadopoulou Deborah (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Prague Julia K. (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Bech Paul (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Godsland Ian F. (Section of Metabolic Medicine, Department of Medicine, Imperial College London, St Mary’s Hospital, London, UK) ,  Bassett Paul (Statsconsultancy Ltd, Amersham, UK) ,  Sands Caroline (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Camuzeaux Stephane (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Gomez-Romero Maria (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Pearce Jake T. M. (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Lewis Matthew R. (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Holmes Elaine (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Nicholson Jeremy K. (The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK) ,  Tan Tricia (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Ratnasabapathy Risheka (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Hu Ming (Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Hu Ming (Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK) ,  Carrat Gaelle (Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Carrat Gaelle (Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK) ,  Piemonti Lorenzo (Diabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Piemonti Lorenzo (Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy) ,  Bugliani Marco (Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy) ,  Marchetti Piero (Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy) ,  Johnson Paul R. (Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK) ,  Johnson Paul R. (Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK) ,  Johnson Paul R. (National Institute of Health Research Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK) ,  Hughes Stephen J. (Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK) ,  Hughes Stephen J. (Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK) ,  Hughes Stephen J. (National Institute of Health Research Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK) ,  James Shapiro A. M. (Clinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta, Edmonton, Canada) ,  Rutter Guy A. (Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK) ,  Rutter Guy A. (Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK) ,  Dhillo Waljit S. (Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK)
資料名： Diabetes Obesity & Metabolism  (Diabetes Obesity & Metabolism)
巻： 20  号： 12  ページ： 2800-2810  発行年： 2018年 
JST資料番号： W2549A  ISSN： 1462-8902  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 【目的】ヒトにおけるグルコース刺激インシュリン分泌と食欲に及ぼすキスペプチンの影響を研究する。材料と方法:15人の健康な男性(年齢:25.2±1.1歳;BMI:22.3±0.5kg m~-2)において,グルコース刺激インシュリン分泌,代謝産物,腸ホルモン,食欲および食物摂取に対する1nmol kg(-1)h~(-1)キスペプチンの効果を比較した。加えて,著者らはヒト膵島およびヒトβ細胞系(EndoC-βH1細胞)におけるin vitroでのグルコース刺激インシュリン分泌に及ぼすキスペプチンの影響を評価した。結果:健常男性へのキスペプチン投与は,静脈内グルコース負荷後のインシュリン分泌を増強し,血清代謝産物を調節した。これにより,キスペプチンはヒト膵島およびヒト膵臓細胞系からグルコース刺激インシュリン分泌をin vitroで増加させた。加えて,キスペプチン投与は,健康な男性において腸ホルモン,食欲または食物摂取を変化させなかった。結論:まとめると,これらのデータは,in vivoでのヒトにおけるインシュリン分泌におけるキスペプチンの有益な役割を初めて示す。これは,ヒトにおける生殖と代謝の間のリンクの理解,ならびに生殖および潜在的代謝条件に対するキスペプチンに基づく治療の進行中の翻訳発達に対する重要な意味を有する。Copyright 2018 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *血清 ,  *代謝産物 ,  男性 ,  ホルモン ,  *代謝 ,  Langerhans島 ,  投与 ,  *食欲 ,  in vitro実験 ,  *ヒト ,  ヘキソース ,  アルドース
準シソーラス用語： 健康 ,  インスリン分泌 , 【Automatic Indexing@JST】

著者キーワード (6件)： 食欲制御 ,  ベータ細胞機能 ,  グルコース代謝 ,  インクレチン ,  インスリン分泌 ,  膵島

分類 (1件)： 細胞生理一般  (EF02010S)

物質索引 (1件)： グルコース

タイトルに関連する用語 (6件)： ヒト ,  細胞機能 ,  血清 ,  代謝物 ,  食欲 ,  キスペプチン