文献

J-GLOBAL ID：201802233373349829   整理番号：18A1429351

転移性前立腺癌におけるゲノム特徴と構造変異【JST・京大機械翻訳】

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

著者 (90件)： Quigley David A. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA) ,  Quigley David A. (Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA) ,  Dang Ha X. (McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA) ,  Dang Ha X. (Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO, USA) ,  Zhao Shuang G. (Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA) ,  Lloyd Paul (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Aggarwal Rahul (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Alumkal Joshi J. (Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA) ,  Alumkal Joshi J. (Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA) ,  Foye Adam (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Kothari Vishal (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Perry Marc D. (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Bailey Adina M. (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Playdle Denise (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Barnard Travis J. (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Zhang Li (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Zhang Jin (Cancer Biology Division, Department of Radiation Oncology, Washington University in St. Louis, MO USA) ,  Zhang Jin (Institute for Informatics (I2), Washington University in St. Louis, MO) ,  Youngren Jack F. (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Cieslik Marcin P. (Department of Pathology, University of Michigan, Ann Arbor, MI, USA) ,  Cieslik Marcin P. (Michigan Center for Translational Pathology, Ann Arbor, MI, USA) ,  Parolia Abhijit (Department of Pathology, University of Michigan, Ann Arbor, MI, USA) ,  Parolia Abhijit (Michigan Center for Translational Pathology, Ann Arbor, MI, USA) ,  Beer Tomasz M. (Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA) ,  Thomas George (Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA) ,  Thomas George (Department of Pathology, Oregon Health and Science University, Portland, OR, USA) ,  Chi Kim N. (Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada) ,  Chi Kim N. (British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC, Canada) ,  Gleave Martin (Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada) ,  Lack Nathan A. (Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada) ,  Zoubeidi Amina (Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada) ,  Reiter Robert E. (Jonsson Comprehensive Cancer Center, Department of Urology, UCLA, Los Angeles, CA, USA) ,  Reiter Robert E. (VA Greater Los Angeles Healthcare System, Department of Medicine, Los Angeles, CA, USA) ,  Rettig Matthew B. (Jonsson Comprehensive Cancer Center, Department of Urology, UCLA, Los Angeles, CA, USA) ,  Witte Owen (Department of Microbiology, Immunology, and Molecular Genetics at the David Geffen School of Medicine, UCLA, Los Angeles, CA, USA) ,  Ryan Charles J. (Division of Hematology, Oncology, and Transplant, Department of Medicine, University of Minnesota, Minneapolis, MN, USA) ,  Fong Lawrence (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Kim Won (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Friedlander Terence (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Chou Jonathan (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Li Haolong (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Das Rajdeep (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Li Hui (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Moussavi-Baygi Ruhollah (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Goodarzi Hani (Department of Biophysics and Biochemistry, UCSF, San Francisco, CA, USA) ,  Goodarzi Hani (Department of Urology, UCSF, San Francisco, CA, USA) ,  Gilbert Luke A. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA) ,  Gilbert Luke A. (Department of Urology, UCSF, San Francisco, CA, USA) ,  Lara Primo N. (Division of Hematology Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA) ,  Lara Primo N. (Comprehensive Cancer Center, University of California Davis, Sacramento, CA, USA) ,  Evans Christopher P. (Comprehensive Cancer Center, University of California Davis, Sacramento, CA, USA) ,  Evans Christopher P. (Department of Urologic Surgery, University of California Davis, Sacramento, CA, USA) ,  Goldstein Theodore C. (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Goldstein Theodore C. (UC Sant Cruz Genome Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA) ,  Stuart Joshua M. (UC Sant Cruz Genome Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA) ,  Tomlins Scott A. (Department of Pathology, University of Michigan, Ann Arbor, MI, USA) ,  Tomlins Scott A. (Department of Urology, University of Michigan, Ann Arbor, MI, USA) ,  Spratt Daniel E. (Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA) ,  Cheetham R. Keira (Illumina, Inc., San Diego, CA, USA) ,  Cheng Donavan T. (Illumina, Inc., San Diego, CA, USA) ,  Farh Kyle (Illumina, Inc., San Diego, CA, USA) ,  Gehring Julian S. (Illumina, Inc., San Diego, CA, USA) ,  Hakenberg Jorg (Illumina, Inc., San Diego, CA, USA) ,  Liao Arnold (Illumina, Inc., San Diego, CA, USA) ,  Febbo Philip G. (Illumina, Inc., San Diego, CA, USA) ,  Shon John (Illumina, Inc., San Diego, CA, USA) ,  Sickler Brad (Illumina, Inc., San Diego, CA, USA) ,  Batzoglou Serafim (Illumina, Inc., San Diego, CA, USA) ,  Knudsen Karen E. (Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA) ,  He Housheng H. (Princess Margaret Cancer Centre/University Health Network, Toronto, ON, Canada) ,  Huang Jiaoti (Department of Pathology, Duke University, Durham, NC, USA) ,  Wyatt Alexander W. (Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada) ,  Dehm Scott M. (Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA) ,  Dehm Scott M. (Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA) ,  Ashworth Alan (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA) ,  Ashworth Alan (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Chinnaiyan Arul M. (Department of Pathology, University of Michigan, Ann Arbor, MI, USA) ,  Chinnaiyan Arul M. (Michigan Center for Translational Pathology, Ann Arbor, MI, USA) ,  Chinnaiyan Arul M. (Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA) ,  Chinnaiyan Arul M. (Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI, USA) ,  Chinnaiyan Arul M. (Department of Urology, University of Michigan, Ann Arbor, MI, USA) ,  Chinnaiyan Arul M. (Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA) ,  Maher Christopher A. (McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA) ,  Maher Christopher A. (Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO, USA) ,  Small Eric J. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA) ,  Small Eric J. (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Feng Felix Y. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA) ,  Feng Felix Y. (Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA) ,  Feng Felix Y. (Department of Radiation Oncology, UCSF, San Francisco, CA, USA) ,  Feng Felix Y. (Department of Urology, UCSF, San Francisco, CA, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 174  号： 3  ページ： 758-769.e9  発行年： 2018年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 蛋白質コード領域に影響を及ぼす突然変異は多くの癌を通して調べられているが,ゲノムワイドレベルでの構造的変異体はまだ十分に定義されていない。101の去勢耐性前立腺癌転移(109x腫瘍/38X正常範囲)の統合的深い全ゲノムとトランスクリプトーム解析を通して,腫瘍形成の重要な調節因子を変化させる構造的変異体を同定し,exomeアプローチによって検出できない進行を同定した。注目すべきことに,81%の患者でアンドロゲン受容体(AR)の上流の624kbの遺伝子間エンハンサー領域の増幅を観察し,AR発現の増加と相関した。タンデム重複ホットスポットも,翻訳後MYC調節に関連するlncRNAにおいてMYC近傍で発生する。構造変化のクラスは異なるDNA修復欠陥と関連しており,CDK12変異とタンデム複製との関連,逆再配列によるTP53不活性化,及び欠失によるBRCA2不活性化を含むそれらの病因を示唆した。まとめると,これらの観察は,構造変化が転移性前立腺癌における重要な調節因子にどのように影響するかの包括的な見解を提供する。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： DNA修復 ,  患者 ,  腫瘍 ,  エンハンサー領域 ,  突然変異 ,  ホットスポット ,  不活性化 ,  *変異 ,  *前立腺 ,  *ゲノム ,  病因 ,  腫瘍転移 ,  タンパク質
準シソーラス用語： TP53 ,  調節因子 , 【Automatic Indexing@JST】

著者キーワード (10件)： ゲノミクス ,  全ゲノム配列決定 ,  去勢抵抗性前立腺癌 ,  転移 ,  構造変化 ,  タンデム重複 ,  遺伝子融合 ,  アンドロゲン受容体 ,  BRCA2 ,  色素沈着症

分類 (3件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  生物学的機能  (EB03040U) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (3件)： 転移性前立腺癌 ,  ゲノム ,  変異