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J-GLOBAL ID：201802235071565101   整理番号：18A1309816

CDKN2Aの二対立遺伝子消失はBrn2活性化を介して黒色腫浸潤を開始する【JST・京大機械翻訳】

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

著者 (44件)： Zeng Hanlin (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Zeng Hanlin (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Jorapur Aparna (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Jorapur Aparna (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Shain A. Hunter (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Shain A. Hunter (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Shain A. Hunter (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Lang Ursula E. (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Lang Ursula E. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Lang Ursula E. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Torres Rodrigo (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Torres Rodrigo (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Zhang Yuntian (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Zhang Yuntian (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  McNeal Andrew S. (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  McNeal Andrew S. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Botton Thomas (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Botton Thomas (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Botton Thomas (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Lin Jue (Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA) ,  Donne Matthew (Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA) ,  Bastian Ingmar N. (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Bastian Ingmar N. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Bastian Ingmar N. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Yu Richard (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Yu Richard (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Yu Richard (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Yu Richard (Faculty of Medicine, University of British Columbia, Vancouver, BC V6T1Z3, Canada) ,  North Jeffrey P. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  North Jeffrey P. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Pincus Laura (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Pincus Laura (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Ruben Beth S. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Ruben Beth S. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Ruben Beth S. (Palo Alto Medical Foundation, Palo Alto, CA 94301, USA) ,  Joseph Nancy M. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Yeh Iwei (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Yeh Iwei (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Yeh Iwei (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Bastian Boris C. (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Bastian Boris C. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Bastian Boris C. (Department of Pathology, University of California San Francisco, San Francisco, CA 94115, USA) ,  Judson Robert L. (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA) ,  Judson Robert L. (Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA)
資料名： Cancer Cell  (Cancer Cell)
巻： 34  号： 1  ページ： 56-68.e9  発行年： 2018年 
JST資料番号： W1844A  ISSN： 1535-6108  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： CDKN2A腫瘍抑制因子の消失はメラノーマ転移と関連するが,現象を結び付ける機構は不明である。初代ヒトメラニン細胞からのメラノーマ開始の細胞モデルを作成するためにCRISPR-Cas9を用いて,系統制限転写因子,BRN2はCDKN2Aの下流で,E2F1により直接調節されることを見出した。異なる進行段階を捕捉するメラニン細胞腫瘍のコホートにおいて,CDKN2A消失は侵襲的挙動の開始及び増加したBRN2発現と一致することを観察した。CDKN2A蛋白質産物p16~INK4Aの消失は,BRN2の阻害により救済された表現型,マウスにおけるヒトメラノーマ系の転移性播種を可能にした。これらの結果は,CDKN2AがBRN2の阻害を介してメラノーマ侵入の開始を抑制する機構を示す。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 腫瘍 ,  *浸潤 ,  母集団 ,  メラニン細胞 ,  転写因子 ,  *黒色腫 ,  タンパク質 ,  ヒト ,  表現型 ,  *対立遺伝子 ,  *p16遺伝子
準シソーラス用語： 侵入 ,  転移性 ,  E2F1転写因子 ,  Cas9 , 【Automatic Indexing@JST】

著者キーワード (7件)： CDKN2A ,  メラノーマ ,  侵入 ,  メラニン細胞 ,  CRISPRエンジニアリング ,  E2F1 ,  BrN2

分類 (1件)： 腫ようの化学・生化学・病理学  (GE02030N)

タイトルに関連する用語 (5件)： CDKN2A ,  対立遺伝子 ,  活性化 ,  黒色腫 ,  浸潤