文献

J-GLOBAL ID：201802235400349113   整理番号：18A0337026

昆虫病原性菌類Lecanicillium antillanumから単離された新規11 ノルベタエノン【Powered by NICT】

Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicillium antillanum

著者 (25件)： Li Chi-Ying (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Lo I-Wen (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Wang Shih-Wei (Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan) ,  Hwang Tsong-Long (Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan) ,  Hwang Tsong-Long (Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan) ,  Hwang Tsong-Long (Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan) ,  Chung Yu-Ming (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Cheng Yuan-Bin (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Cheng Yuan-Bin (Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Cheng Yuan-Bin (Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Tseng Sung-Pin (Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Liu Yi-Hung (Instrumentation Center, National Taiwan University, Taipei 106, Taiwan) ,  Hsu Yu-Ming (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Chen Shu-Rong (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Hu Hao-Chun (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Chang Fang-Rong (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Chang Fang-Rong (Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Chang Fang-Rong (Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan) ,  Chang Fang-Rong (Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan) ,  Chang Fang-Rong (Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Wu Yang-Chang (Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan) ,  Wu Yang-Chang (School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan) ,  Wu Yang-Chang (Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan) ,  Wu Yang-Chang (Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan) ,  Wu Yang-Chang (Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 27  号： 9  ページ： 1978-1982  発行年： 2017年 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 新しいもベタエノン化合物,11 ノルベタエノン(1)は,昆虫病原性菌類Lecanicillium antillanumの培養液より分離した。構造は1D及び2D NMR分光データに基づいて決定した。1の絶対立体化学はさらにX線単結晶学分析により確認した。種Lecanicillium antillanumから報告された最初の二次代謝産物である。ベタエノン型化合物は属Lecanicilliumから単離したことも初めて。11 ノルベタエノン(1)は管形成を抑制することにより有意な抗血管新生効果を示した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 二次元 ,  一次元 ,  立体化学 ,  NMR【磁気共鳴】 ,  単結晶 ,  二次代謝産物 ,  X線 ,  *昆虫類
準シソーラス用語： 血管新生阻害作用 ,  管腔形成 , 【Automatic Indexing@JST】

著者キーワード (5件)： Lecanicillium antillanum ,  ベタエノン ,  二次代謝産物 ,  ポリケチドシンターゼ ,  抗血管新生作用

分類 (1件)： 微生物の生化学  (EG03020N)

タイトルに関連する用語 (4件)： 昆虫 ,  病原性菌 ,  Lecanicillium ,  単離