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J-GLOBAL ID：201802238096618700   整理番号：18A0282639

前駆期アルツハイマー病における認知症リスク因子の頻度と影響【Powered by NICT】

The frequency and influence of dementia risk factors in prodromal Alzheimer’s disease

著者 (66件)： Bos Isabelle (Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands) ,  Vos Stephanie J. (Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands) ,  Frolich Lutz (On behalf of German Dementia Competence Network) ,  Frolich Lutz (Department of Geriatric Psychiatry, Zentralinstitut fuer Seelische Gesundheit, University of Heidelberg, Mannheim, Germany) ,  Kornhuber Johannes (On behalf of German Dementia Competence Network) ,  Kornhuber Johannes (Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nuernberg, Erlangen, Germany) ,  Wiltfang Jens (On behalf of German Dementia Competence Network) ,  Wiltfang Jens (Department of Psychiatry and Psychotherapy, University Medical Center (UMC), Georg-August-University, Gottingen, Germany) ,  Maier Wolfgang (On behalf of German Dementia Competence Network) ,  Maier Wolfgang (Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany) ,  Peters Oliver (On behalf of German Dementia Competence Network) ,  Peters Oliver (Department of Psychiatry and Psychotherapy, Charite Berlin, Berlin, Germany) ,  Ruether Eckhart (On behalf of German Dementia Competence Network) ,  Ruether Eckhart (Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany) ,  Engelborghs Sebastiaan (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ,  Engelborghs Sebastiaan (Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium) ,  Niemantsverdriet Ellis (Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium) ,  De Roeck Ellen Elisa (Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium) ,  De Roeck Ellen Elisa (Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium) ,  Tsolaki Magda (3rd Department of Neurology, Aristotle University of Thessaloniki, Memory and Dementia Center, “G Papanicolau” General Hospital, Thessaloniki, Greece) ,  Freund-Levi Yvonne (Division of Clinical Geriatrics, Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden) ,  Freund-Levi Yvonne (Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden) ,  Johannsen Peter (Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark) ,  Vandenberghe Rik (Department of Neurology, University of Hospital Leuven, Leuven, Belgium) ,  Vandenberghe Rik (Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium) ,  Lleo Alberto (Hospital de la Santa Creu i Sant Pau, Barcelona, Spain) ,  Alcolea Daniel (Hospital de la Santa Creu i Sant Pau, Barcelona, Spain) ,  Frisoni Giovanni B. (On behalf of the EADC-PET consortium) ,  Frisoni Giovanni B. (Geneva Neuroscience Center, University Hospital and University of Geneva, Geneva, Switzerland) ,  Frisoni Giovanni B. (IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  Galluzzi Samantha (IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  Nobili Flavio (On behalf of the EADC-PET consortium) ,  Nobili Flavio (Clinical Neurology, Department of Neurosciences (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy) ,  Morbelli Silvia (On behalf of the EADC-PET consortium) ,  Morbelli Silvia (Nuclear Medicine, Department of Health Science (DISSAL), University of Genoa IRCCS AOU San Martino-IST, Genoa, Italy) ,  Drzezga Alexander (On behalf of the EADC-PET consortium) ,  Drzezga Alexander (Department of Nuclear Medicine, University of Cologne, Cologne, Germany) ,  Didic Mira (On behalf of the EADC-PET consortium) ,  Didic Mira (AP-HM Hopitaux de la Timone, Service de Neurologie et Neuropsychologie, Marseille, France) ,  Didic Mira (Aix-Marseille Universite, INSERM, Institut de Neurosciences des Systemes, Marseille, France) ,  van Berckel Bart N. (On behalf of the EADC-PET consortium) ,  van Berckel Bart N. (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands) ,  Salmon Eric (Department of Neurology and Memory Clinic, CHU Liege, Liege, Belgium) ,  Salmon Eric (GIGA-CRC in vivo Imaging, University of Liege, Liege, Belgium) ,  Bastin Christine (GIGA-CRC in vivo Imaging, University of Liege, Liege, Belgium) ,  Dauby Solene (Department of Neurology and Memory Clinic, CHU Liege, Liege, Belgium) ,  Santana Isabel (Department of Neurology and Memory Clinic, CHU Liege, Liege, Belgium) ,  Baldeiras Ines (Center for Neuroscience and Cell Biology, Faculty of Medicine, Department of Neurology, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal) ,  de Mendonca Alexandre (Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal) ,  Silva Dina (Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal) ,  Wallin Anders (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden) ,  Nordlund Arto (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden) ,  Coloma Preciosa M. (Real World Data Science (RWD-S) Neuroscience and Established Products, F. Hoffmann-La Roche Ltd. Pharmaceuticals Division, Basel, Switzerland) ,  Wientzek Angelika (PDB RWD (Real World Data) Team, Roche Products Limited, Welwyn Garden City, UK) ,  Wientzek Angelika (Epidemiologische Beratung und Literatur-Recherche “conepi”, Herrsching, Germany) ,  Alexander Myriam (PDB RWD (Real World Data) Team, Roche Products Limited, Welwyn Garden City, UK) ,  Novak Gerald P. (Janssen Pharmaceutical Research and Development, Titusville, NJ, USA) ,  Gordon Mark Forrest (Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA) ,  Wallin Åsa K. (Department of Clinical Sciences Malmo, Lund University, Clinical Memory Research Unit, Lund, Sweden) ,  Hampel Harald (Sorbonne Universites, Universite Pierre et Marie Curie, Paris 06, AXA Research Fund & UPMC Chair, Institut de la Memoire et de la Maladie d’Alzheimer (IM2A) & Institut du Cerveau et de la Moelle epiniere (ICM), Departement de Neurologie, Hopital de la Pitie-Salpetriere, 47 Boulevard de ...) ,  Soininen Hilkka (Institute of Clinical Medicine, Neurology, University of Eastern Finland and Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland) ,  Herukka Sanna-Kaisa (Institute of Clinical Medicine, Neurology, University of Eastern Finland and Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland) ,  Scheltens Philip (Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands) ,  Verhey Frans R. (Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands) ,  Visser Pieter Jelle (Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands) ,  Visser Pieter Jelle (Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands)
資料名： Neurobiology of Aging  (Neurobiology of Aging)
巻： 56  ページ： 33-40  発行年： 2017年 
JST資料番号： W0356A  ISSN： 0197-4580  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 痴呆危険因子は国際ワーキンググループ2と米国国立老化研究所アルツハイマー協会の基準に従って前駆Alzheimer病(AD)と,および認知機能低下と関連していたかどうかを調べた。14異なる研究からの軽度認知障害の総計1394名の被験者をこれらの研究基準,認知性能とバイオマーカーに基づくに従って分類した。サブグループ間の10種類のリスク因子の頻度を比較し,コックス回帰を用いた認知低下に対する危険因子の影響を検討した。うつ病,肥満,高コレステロール血症は低AD尤度患者でしばしば起こり,高AD尤度と比較した。アルコール摂取のみが認知低下のリスクを増加させ,AD病理にかかわらず。これらの結果は,ADのための伝統的な危険因子は前駆期アルツハイマー病または認知症への進行と関連しており,軽度認知障害を有する被験者間ではないことを示唆した。将来の研究は,これらの知見を検証し,危険因子はADの初期段階(すなわち,前臨床)で影響があるかもしれないかどうかを決定すべきである。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *認知症 ,  高コレステロール血症 ,  患者 ,  飲酒 ,  *危険因子 ,  うつ病 ,  バイオマーカー ,  *Alzheimer病 ,  病理
準シソーラス用語： 尤度 ,  被験者 ,  軽度認知障害 ,  認知障害 , 【Automatic Indexing@JST】

著者キーワード (6件)： アルツハイマー病 ,  リスクファクター ,  IWG2基準 ,  NIAAA基準 ,  バイオマーカー ,  予後

分類 (1件)： 神経系の診断  (GN02000H)

タイトルに関連する用語 (4件)： アルツハイマー病 ,  認知症 ,  リスク因子 ,  頻度