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J-GLOBAL ID：201802242904605740   整理番号：18A1299665

腎移植後の後期侵襲性肺アスペルギルス症の発症に対するリスク因子の多国症例対照研究【JST・京大機械翻訳】

Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation

著者 (50件)： Lopez-Medrano F. (Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Instituto de Investigacion Hospital “12 de Octubre” (i+12), Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Fernandez-Ruiz M. (Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Instituto de Investigacion Hospital “12 de Octubre” (i+12), Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Silva J.T. (Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Instituto de Investigacion Hospital “12 de Octubre” (i+12), Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Carver P.L. (University of Michigan College of Pharmacy, Department of Clinical Pharmacy, University of Michigan Health System, Ann Arbor, MI, USA) ,  van Delden C. (Unit of Transplant Infectious Diseases, Department of Medical Specialities, University Hospitals Geneva, Geneva, Switzerland) ,  Merino E. (Unit of Infectious Diseases, Hospital Universitario General, Alicante, Spain) ,  Perez-Saez M.J. (Department of Nephrology, Hospital del Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain) ,  Montero M. (Department of Infectious Diseases, Hospital del Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain) ,  Coussement J. (Department of Nephrology, Dialysis and Kidney Transplantation, CUB-Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium) ,  de Abreu Mazzolin M. (Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo-UNIFESP and Hospital do Rim e Hipertensao, Fundacao Oswaldo Ramos, Sao Paulo, Brazil) ,  Cervera C. (Department of Infectious Diseases, Hospital Clinic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Barcelona, Spain) ,  Santos L. (Unit of Renal Transplantation, Department of Urology and Kidney Transplantation, Coimbra Hospital and University Centre, Coimbra, Portugal) ,  Sabe N. (Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut d’Investigacio Biomedica de Bellvitge (IDIBELL), Barcelona, Spain) ,  Scemla A. (Service de Nephrologie et Transplantation Adulte, Hopital Necker Enfants Malades, Assistance Publique-Hopitaux de Paris, Universite Paris Descartes Sorbonne Paris Cite, RTRS Centaure, Paris, France) ,  Cordero E. (Department of Infectious Diseases, Hospitales Universitarios “Vigen del Rocio”, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain) ,  Cruzado-Vega L. (Department of Nephrology, Hospital Universitario “La Fe”, Valencia, Spain) ,  Martin-Moreno P.L. (Department of Nephrology, Clinica Universitaria de Navarra, Pamplona, Spain) ,  Len O. (Department of Infectious Diseases, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute (VHIR), Barcelona, Spain) ,  Rudas E. (Department of Nephrology, Hospital Universitario “Carlos Haya”, Malaga, Spain) ,  Ponce de Leon A. (Department of Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubiran”, Mexico DF, Mexico) ,  Arriola M. (Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares, Santa Fe, Argentina) ,  Lauzurica R. (Department of Nephrology, University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain) ,  David M.D. (Department of Microbiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK) ,  Gonzalez-Rico C. (Department of Infectious Diseases, University Hospital “Marques de Valdecilla”, Santander, Spain) ,  Henriquez-Palop F. (Department of Nephrology, University Hospital “Doctor Negrin”, Las Palmas de Gran Canaria, Spain) ,  Fortun J. (Department of Infectious Diseases, University Hospital “Ramon y Cajal”, Madrid, Spain) ,  Nucci M. (Department of Internal Medicine, Hematology Service and Mycology Laboratory, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil) ,  Manuel O. (Department of Infectious Diseases and Transplantation Center, University Hospital (CHUV) and University of Lausanne, Switzerland) ,  Pano-Pardo J.R. (Infectious Diseases and Clinical Microbiology Unit, Department of Internal Medicine, Hospital Universitario “La Paz”, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain) ,  Montejo M. (Department of Infectious Diseases, Hospital Universitario Cruces, Barakaldo, Bilbao, Spain) ,  Vena A. (Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Instituto de Investigacion Sanitaria Hospital Gregorio Maranon, Madrid, Spain) ,  Vena A. (CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid Spain) ,  Vena A. (Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain) ,  Sanchez-Sobrino B. (Department of Nephrology, Hospital Universitario Puerta de Hierro-Majadahonda, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain) ,  Mazuecos A. (Department of Nephrology, Hospital Universitario “Puerta del Mar”, Cadiz, Spain) ,  Pascual J. (Department of Nephrology, Hospital del Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain) ,  Horcajada J.P. (Department of Infectious Diseases, Hospital del Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain) ,  Lecompte T. (Unit of Transplant Infectious Diseases, Department of Medical Specialities, University Hospitals Geneva, Geneva, Switzerland) ,  Moreno A. (Department of Infectious Diseases, Hospital Clinic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Barcelona, Spain) ,  Carratala J. (Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut d’Investigacio Biomedica de Bellvitge (IDIBELL), Barcelona, Spain) ,  Blanes M. (Unit of Infectious Diseases, Hospital Universitario “La Fe”, Valencia, Spain) ,  Hernandez D. (Department of Nephrology, Hospital Universitario “Carlos Haya”, Malaga, Spain) ,  Hernandez-Mendez E.A. (Department of Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubiran”, Mexico DF, Mexico) ,  Farinas M.C. (Department of Infectious Diseases, University Hospital “Marques de Valdecilla”, Santander, Spain) ,  Perello-Carrascosa M. (Department of Nephrology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute (VHIR), Barcelona, Spain) ,  Munoz P. (Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Instituto de Investigacion Sanitaria Hospital Gregorio Maranon, Madrid, Spain) ,  Munoz P. (CIBER Enfermedades Respiratorias - CIBERES (CB06/06/0058), Madrid Spain) ,  Munoz P. (Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain) ,  Andres A. (Department of Nephrology, Hospital Universitario “12 de Octubre”, Instituto de Investigacion Hospital “12 de Octubre” (i+12), Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Aguado J.M. (Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Instituto de Investigacion Hospital “12 de Octubre” (i+12), Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain)
資料名： Clinical Microbiology and Infection  (Clinical Microbiology and Infection)
巻： 24  号： 2  ページ： 192-198  発行年： 2018年 
JST資料番号： W3155A  ISSN： 1198-743X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 腎臓移植(KT)後の遅発性侵襲性肺アスペルギルス症(IPA)発症の危険因子を評価する。著者らは,2000年から2013年の間にIPAと診断された112人のKTレシピエントを遡及的に募集した多国籍症例対照研究を実施した。対照は,移植の中心と日付によってマッチした(1:1の比率)。免疫抑制関連イベント(IRE)は,非静脈性関連肺炎,結核,サイトメガロウイルス疾患,および/またはde novo悪性腫瘍の発生を含んでいた。著者らは,全研究に含まれるすべての症例のうち,24の参加センター(54.5%(61/112)を占める)から,61例の後期(移植後>180日)IPAを同定した。大部分の診断(54.1%(33/61))は移植後の最初の36か月以内に確立されたが,5例は移植後10年以上に発生した。全死亡率は47.5%(29/61)であった。対照と比較して,症例は有意に高齢(p0.010)で,前移植慢性閉塞性肺疾患(p0.001)を有する可能性があり,後期IPA発症前の6か月以内に血流感染(p0.016)とIRE(p<0.001)の診断があった。多変量調整の後,IREの以前の発生(OR19.26;95%CI2.07-179.46;p0.009)は,後期IPAの独立危険因子として同定された。KT後のIPA症例の半分以上が6カ月を超えて発生し,それらのいくつかは非常に遅い。後期IPAは予後不良である。著者らは,後期IPAに対する最も高いリスクにおいて,KTレシピエントのサブグループを区切るために臨床医を助けることができるいくつかのリスク因子を同定した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 死亡率 ,  結核 ,  肺炎 ,  慢性閉塞性肺疾患 ,  *腎臓移植 ,  免疫抑制 ,  *症例対照研究 ,  *危険因子 ,  サイトメガロウイルス ,  静脈
準シソーラス用語： 臨床医 ,  予後不良 ,  血流感染症 ,  悪性腫瘍 ,  *発症 , 【Automatic Indexing@JST】

著者キーワード (4件)： ケースコントロール研究 ,  腎臓移植 ,  遅発性侵襲性肺アスペルギルス症 ,  危険因子

分類 (2件)： 感染症・寄生虫症一般  (GD01010H) ,  泌尿生殖器疾患の外科療法  (GM05030G)

タイトルに関連する用語 (5件)： 腎移植 ,  侵襲性肺アスペルギルス症 ,  発症 ,  リスク因子 ,  症例対照研究