文献

J-GLOBAL ID：201802243732168413   整理番号：18A0427608

出生前尿中多環芳香族炭化水素代謝産物,臍帯血における全体的なDNAメチル化,と出生転帰:中国におけるコホート研究【Powered by NICT】

Prenatal urinary polycyclic aromatic hydrocarbon metabolites, global DNA methylation in cord blood, and birth outcomes: A cohort study in China

著者 (21件)： Yang Pan (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Yang Pan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Gong Ya-Jie (Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China) ,  Cao Wen-Cheng (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Cao Wen-Cheng (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Wang Rui-Xin (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Wang Rui-Xin (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Wang Yi-Xin (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Wang Yi-Xin (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Liu Chong (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Liu Chong (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Chen Ying-Jun (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Chen Ying-Jun (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Huang Li-Li (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Huang Li-Li (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Ai Song-Hua (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Ai Song-Hua (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Lu Wen-Qing (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Lu Wen-Qing (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Qiang (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Qiang (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China)
資料名： Environmental Pollution  (Environmental Pollution)
巻： 234  ページ： 396-405  発行年： 2018年 
JST資料番号： D0984B  ISSN： 0269-7491  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 多環芳香族炭化水素(PAHs)への出生前の曝露は不運な誕生結果の潜在的危険因子である。後成的機構は,PAHsがその作用を発揮する重要な役割を果たしている可能性がある。著者らの研究は,出生前PAH曝露は不運な誕生結果と変化したDNAメチル化と関連していたかどうかを調べるために,DNAメチル化の潜在的媒介役割を探索することを目的とした。十尿中PAH代謝産物は中国人コホート研究における妊娠後期の106人の妊婦から測定した。グローバルDNAメチル化の代理として長鎖散在反復配列1(LINE 1)とAlu反復要素における臍帯血DNAメチル化は亜硫酸水素塩ピロシークエンス法によって解析した。多変量線形回帰を用いて,出産結果とDNAメチル化と尿中PAH代謝産物の関連を推定し,媒介分析も行った。出生前尿2-ヒドロキシナフタレン(2 OHNa),ΣOHNa(1 2OHNaの合計),モノヒドロキシPAHの合計(ΣOH PAHs)は,より低い出生時身長(例えば, 0.80%,95%CI: 1.39%,2OHNaの三対第1三分位値の 0.20%;P傾向=0.01)と関連していた。出生前尿中2OHNaと1-ヒドロキシフェナントレン(1 OHPh)は低AluとLINE-1メチル化(例えば,1.88%,95%CI:3.73%,Aluメチル化における2OHNaの三対第1三分位値三分位値の 0.10%;傾向=0.04)と関連していた。仲介分析は出生前尿OH-PAHsと出産結果との関連におけるグローバルなDNAメチル化のメディエーター効果を示さなかった。出生前特定PAH曝露は減少した出生時身長およびグローバルDNAメチル化と関連している。しかし,グローバルなDNAメチル化は出生転帰と出生前PAH曝露との関連を仲介しない。結果を確認するためにさらなる研究が必要である。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： エピジェネティクス ,  危険因子 ,  *中華人民共和国 ,  妊婦 ,  *メチル化 ,  妊娠後期 ,  *コホート研究 ,  *芳香族縮合炭化水素 ,  *臍帯血 ,  *代謝産物
準シソーラス用語： 出生時身長 ,  出産 ,  ピロシークエンス法 ,  *DNAメチル化 ,  *出生 , 【Automatic Indexing@JST】

著者キーワード (5件)： 出産結果 ,  臍帯血 ,  DNAメチル化 ,  エピジェネティクス ,  多環芳香族炭化水素

分類 (2件)： その他の汚染原因物質  (SB05040W) ,  動物に対する影響  (EE05040R)

タイトルに関連する用語 (10件)： 尿 ,  多環芳香族炭化水素 ,  代謝産物 ,  臍帯血 ,  DNAメチル化 ,  出生 ,  転帰 ,  中国 ,  コホート ,  研究