文献

J-GLOBAL ID：201802247440080379   整理番号：18A1362311

Alzheimer病のスペクトラムを越えたアミロイドβ陽性被験者におけるアポリポ蛋白質E ε4対立遺伝子の有病率【JST・京大機械翻訳】

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer’s disease

著者 (111件)： Mattsson Niklas (Clinical Memory Research Unit, Clinical Sciences Malmo, Lund University, Lund, Sweden) ,  Groot Colin (Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands) ,  Jansen Willemijn J. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands) ,  Landau Susan M. (Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA) ,  Villemagne Victor L. (Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia) ,  Engelborghs Sebastiaan (Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium) ,  Mintun Mark M. (Avid Radiopharmaceuticals, Philadelphia, PA, USA) ,  Lleo Alberto (Neurology Department, Hospital de Sant Pau, Barcelona, Spain) ,  Molinuevo Jose Luis (Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain) ,  Jagust William J. (Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA) ,  Frisoni Giovanni B. (Memory Clinic and LANVIE- Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland) ,  Frisoni Giovanni B. (Laboratory of Alzheimer’s Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  Ivanoiu Adrian (Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Universite catholique de Louvain, Brussels, Belgium) ,  Chetelat Gaeel (Inserm, Inserm UMR-S U1237, Universite de Caen-Normandie, GIP Cyceron, Caen, France) ,  Resende de Oliveira Catarina (Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal) ,  Rodrigue Karen M. (Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA) ,  Kornhuber Johannes (Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany) ,  Wallin Anders (Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden) ,  Klimkowicz-Mrowiec Aleksandra (Jagiellonian University College of Medicine, Krakow, Poland) ,  Kandimalla Ramesh (Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India) ,  Popp Julius (Department of Psychiatry, Service of Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland) ,  Aalten Pauline P. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands) ,  Aarsland Dag (Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway) ,  Alcolea Daniel (Neurology Department, Hospital de Sant Pau, Barcelona, Spain) ,  Almdahl Ina S. (Department of Neurology, Akershus University Hospital, Lorenskog, Norway) ,  Baldeiras Ines (Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal) ,  van Buchem Mark A. (Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands) ,  Cavedo Enrica (Laboratory of Alzheimer’s Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  Cavedo Enrica (AXA Research Fund & UPMC Chair, Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Epiniere (ICM), Departement de Neurologie, Institut de la Memoire et de la Maladie d’Alzheimer (IM2A), Hopital Pitie-Salpetriere, Paris...) ,  Chen Kewei (Banner Alzheimer’s Institute, Phoenix, AZ, USA) ,  Cohen Ann D. (University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA) ,  Forster Stefan (Department of Nuclear Medicine, Technische Universitaet Muenchen, Munich, Germany) ,  Fortea Juan (Neurology Department, Hospital de Sant Pau, Barcelona, Spain) ,  Frederiksen Kristian S. (Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ,  Freund-Levi Yvonne (Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden) ,  Gill Kiran Dip (Department of Biochemistry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India) ,  Gkatzima Olymbia (Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Grimmer Timo (Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet Muenchen, Munich, Germany) ,  Hampel Harald (AXA Research Fund & UPMC Chair, Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Epiniere (ICM), Departement de Neurologie, Institut de la Memoire et de la Maladie d’Alzheimer (IM2A), Hopital Pitie-Salpetriere, Paris...) ,  Hampel Harald (Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany) ,  Herukka Sanna-Kaisa (Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland) ,  Johannsen Peter (Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark) ,  van Laere Koen (Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium) ,  de Leon Mony J. (School of Medicine, Center for Brain Health, New York University, New York, NY, USA) ,  Maier Wolfgang (Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany) ,  Marcusson Jan (Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linkoping, Linkoping, Sweden) ,  Meulenbroek Olga (Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Mollergard Hanne M. (Department of Neurology, Akershus University Hospital, Lorenskog, Norway) ,  Morris John C. (Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA) ,  Mroczko Barbara (Department of Neurodegeneration Diagnostics, Leading National Research Centre in Bialystok (KNOW), Medical University of Bialystok, Bialystok, Poland) ,  Nordlund Arto (Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden) ,  Prabhakar Sudesh (Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India) ,  Peters Oliver (Department of Psychiatry and Psychotherapy, Charite Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany) ,  Rami Lorena (Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain) ,  Rodriguez-Rodriguez Eloy (Neurology Service, Universitary Hospital Marques de Valdecilla, CIBERNED, IDIVAL, Santander, Spain) ,  Roe Catherine M. (Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA) ,  Ruether Eckart (Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Gottingen, Germany) ,  Santana Isabel (Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal) ,  Schroder Johannes (Sektion Gerontopsychiatrie, Universitaet Heidelberg, Heidelberg, Germany) ,  Seo Sang W. (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea) ,  Soininen Hilkka (Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland) ,  Spiru Luiza (Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania) ,  Stomrud Erik (Clinical Memory Research Unit, Clinical Sciences Malmo, Lund University, Lund, Sweden) ,  Struyfs Hanne (Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium) ,  Teunissen Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands) ,  Verhey Frans R.J. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands) ,  Vos Stephanie J.B. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands) ,  van Waalwijk van Doorn Linda J.C. (Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands) ,  van Waalwijk van Doorn Linda J.C. (Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Waldemar Gunhild (Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ,  Wallin Åsa K. (Clinical Memory Research Unit, Clinical Sciences Malmo, Lund University, Lund, Sweden) ,  Wiltfang Jens (Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Gottingen, Germany) ,  Wiltfang Jens (Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Gottingen, Germany) ,  Vandenberghe Rik (Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium) ,  Brooks David J. (Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK) ,  Fladby Tormod (Department of Neurology, Akershus University Hospital, Lorenskog, Norway) ,  Rowe Christopher C. (Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia) ,  Drzezga Alexander (Department of Nuclear Medicine, University of Cologne, Cologne, Germany) ,  Verbeek Marcel M. (Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Verbeek Marcel M. (Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands) ,  Sarazin Marie (Neurologie de la Memoire et du Langage, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France) ,  Wolk David A. (Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA) ,  Fleisher Adam S. (Banner Alzheimer’s Institute, Phoenix, AZ, USA) ,  Fleisher Adam S. (Eli Lilly, Indianapolis, IN, USA) ,  Fleisher Adam S. (Department of Neurosciences, University of California, San Diego, CA, USA) ,  Klunk William E. (University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA) ,  Na Duk L. (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea) ,  Sanchez-Juan Pascual (Neurology Service, Universitary Hospital Marques de Valdecilla, CIBERNED, IDIVAL, Santander, Spain) ,  Lee Dong Young (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea) ,  Nordberg Agneta (Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden) ,  Tsolaki Magda (Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Camus Vincent ,  Rinne Juha O. ,  Fagan Anne M. (Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA) ,  Zetterberg Henrik ,  Zetterberg Henrik ,  Zetterberg Henrik ,  Zetterberg Henrik ,  Blennow Kaj ,  Blennow Kaj ,  Rabinovici Gil D. ,  Hansson Oskar (Clinical Memory Research Unit, Clinical Sciences Malmo, Lund University, Lund, Sweden) ,  van Berckel Bart N.M. ,  van der Flier Wiesje M. (Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands) ,  van der Flier Wiesje M. ,  Scheltens Philip (Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands) ,  Visser Pieter Jelle (Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands) ,  Visser Pieter Jelle (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands) ,  Ossenkoppele Rik (Clinical Memory Research Unit, Clinical Sciences Malmo, Lund University, Lund, Sweden) ,  Ossenkoppele Rik (Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands) ,  Ossenkoppele Rik
資料名： Alzheimer’s & Dementia: Journal of the Alzheimer’s Association  (Alzheimer's & Dementia: Journal of the Alzheimer's Association)
巻： 14  号： 7  ページ： 913-924  発行年： 2018年 
JST資料番号： W3115A  ISSN： 1552-5260  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： アポリポ蛋白質E(APOE)ε4はアルツハイマー病(AD)の主要な遺伝的危険因子であるが,以前の研究はアミロイドβ(Aβ)病理のバイオマーカー証拠を必要としないので,その罹患率は不明である。3451人のAβ+被験者(853人のAD型認知症,1810人の軽度認知障害,および788人の認知正常)を含んだ。一般化推定方程式モデルを用いて年齢,性別,教育および地理的位置に関するAPOEε4罹患率を評価した。APOEε4罹患率はAD型認知症で66%,軽度認知障害で64%,認知正常で51%であり,Aβ+AD認知症(P<.05)ではなく,Aβ+認知正常およびAβ+軽度認知障害(P<.05)で年齢の進行とともに減少したが,Aβ+AD認知症では減少しなかった(P<.66)。有病率はヨーロッパ北部で最も高かったが,性または教育によって変化しなかった。ADにおけるAPOEε4罹患率は,以前の研究におけるそれより高かった。それはAβ病理の存在を必要としなかった。さらに,著者らの結果は,年齢と地理的位置に関連する疾患不均一性を強調する。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 教育 ,  *アミロイド ,  *スペクトル ,  地理学 ,  ヨーロッパ ,  *対立遺伝子 ,  *Alzheimer病 ,  病理 ,  バイオマーカー ,  *アミロイドβタンパク質 ,  *アポE ,  認知症
準シソーラス用語： *被験者 ,  軽度認知障害 ,  性別 , 【Automatic Indexing@JST】

著者キーワード (12件)： APOE ,  有病率 ,  アミロイド ,  PET ,  CSF ,  アルツハイマー病 ,  軽度認知障害 ,  主観的認知低下 ,  年齢 ,  性性 ,  教育 ,  地理的位置

分類 (3件)： 生物学的機能  (EB03040U) ,  神経系の診断  (GN02000H) ,  神経系の疾患  (GN03000O)

タイトルに関連する用語 (7件)： Alzheimer病 ,  スペクトラム ,  アミロイドβ ,  被験者 ,  アポリポ蛋白質E ,  対立遺伝子 ,  有病率