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J-GLOBAL ID：201802261310871413   整理番号：18A0819721

糖摂取と関連したFGF21における共通対立遺伝子は身体形状,低総脂肪率および高血圧と関連する【JST・京大機械翻訳】

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

著者 (30件)： Frayling Timothy M. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Beaumont Robin N. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Jones Samuel E. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Yaghootkar Hanieh (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Tuke Marcus A. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Ruth Katherine S. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Casanova Francesco (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Casanova Francesco (Diabetes and Vascular Research Centre, University of Exeter Medical School, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  West Ben (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Locke Jonathan (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Sharp Seth (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Ji Yingjie (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Thompson William (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Harrison Jamie (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Etheridge Amy S. (The University of North Carolina, Eshelman School of Pharmacy and Center for Pharmacogenomics and Individualized Therapy, Chapel Hill, NC, USA) ,  Gallins Paul J. (Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA) ,  Jima Dereje (Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA) ,  Wright Fred (Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA) ,  Zhou Yihui (Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA) ,  Innocenti Federico (The University of North Carolina, Eshelman School of Pharmacy and Center for Pharmacogenomics and Individualized Therapy, Chapel Hill, NC, USA) ,  Lindgren Cecilia M. (Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK) ,  Lindgren Cecilia M. (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Lindgren Cecilia M. (Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA) ,  Grarup Niels (Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Murray Anna (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Freathy Rachel M. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Weedon Michael N. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Tyrrell Jessica (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK) ,  Tyrrell Jessica (European Centre for Environment and Human Health, University of Exeter Medical School, The Knowledge Spa, Royal Cornwall Hospital, Truro TR1 3HD, UK) ,  Wood Andrew R. (Genetics of Complex Traits, University of Exeter Medical School, RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK)
資料名： Cell Reports  (Cell Reports)
巻： 23  号： 2  ページ： 327-336  発行年： 2018年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 線維芽細胞成長因子21(FGF21)はインシュリン感作性を有するホルモンである。FGF21類似体のいくつかの試験は,体重減少と脂質低下効果を示す。最近の研究は,FGF21遺伝子における共通対立遺伝子が消費される多量体のバランスを変えることを示したが,代謝形質に対する影響の証拠はほとんどなかった。著者らは,英国バイオバンク研究から451,099人の一般的FGF21対立遺伝子(A:rs838133)を研究し,標的FGF21の潜在的有害および有益な効果を知らせるためにヒト対立遺伝子を使用することを目的とした。A対立遺伝子とより高い炭水化物摂取量の間の関係を複製した。次に,この対立遺伝子は,BMIまたは2型糖尿病を伴うよりも,より低い総体脂肪率との関連にもかかわらず,より高い血圧およびウエスト-ヒップ比とより強く関連していることを示した。FGF21遺伝子の変異のこれらのヒト表現型はFGF21の機構と治療的可能性への研究を知らせるであろう。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： インスリン ,  脂質 ,  体重減少 ,  *高血圧症 ,  *血圧 ,  代謝 ,  2型糖尿病 ,  表現型 ,  治療法 ,  FGF【成長因子】 ,  *対立遺伝子 ,  ヒト
準シソーラス用語： 体脂肪率 ,  摂取量 ,  *FGF21 , 【Automatic Indexing@JST】

著者キーワード (8件)： FGF21 ,  BMI ,  ウエスト-股関節比 ,  血圧 ,  体脂肪 ,  対立遺伝子 ,  遺伝子変異 ,  英国バイオバンク

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (6件)： 糖 ,  FGF21 ,  対立遺伝子 ,  身体 ,  脂肪 ,  高血圧