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J-GLOBAL ID：201802261516361905   整理番号：18A0158609

可逆的リジンAminoacylationsによるセンシングと送信細胞内アミノ酸シグナル【Powered by NICT】

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

著者 (48件)： He Xia-Di (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  He Xia-Di (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  He Xia-Di (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Gong Wei (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Gong Wei (Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, PRC) ,  Zhang Jia-Nong (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Zhang Jia-Nong (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Zhang Jia-Nong (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Nie Ji (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Nie Ji (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Nie Ji (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Yao Cui-Fang (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Yao Cui-Fang (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Yao Cui-Fang (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Guo Fu-Shen (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Guo Fu-Shen (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Lin Yan (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Lin Yan (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Wu Xiao-Hui (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Wu Xiao-Hui (Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, PRC) ,  Li Feng (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Li Feng (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Li Feng (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Li Jie (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Li Jie (Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, PRC) ,  Sun Wei-Cheng (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC) ,  Wang En-Duo (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC) ,  An Yan-Peng (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  An Yan-Peng (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Tang Hui-Ru (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Tang Hui-Ru (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Yan Guo-Quan (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Yang Peng-Yuan (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Wei Yun (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Wei Yun (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Mao Yun-Zi (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Mao Yun-Zi (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Lin Peng-Cheng (Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities, Xining 810007, PRC) ,  Zhao Jian-Yuan (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Zhao Jian-Yuan (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC) ,  Xu Yanhui (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Xu Yanhui (Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, PRC) ,  Xu Yanhui (CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, PRC) ,  Xu Wei (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Xu Wei (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Zhao Shi-Min (Obstetrics and Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PRC) ,  Zhao Shi-Min (Key Laboratory of Reproduction Regulation of NPFPC (SIPPR,IRD) and Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, PRC) ,  Zhao Shi-Min (State Key Laboratory of Biotherapy/ Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PRC)
資料名： Cell Metabolism  (Cell Metabolism)
巻： 27  号： 1  ページ： 151-166.e6  発行年： 2018年 
JST資料番号： W3108A  ISSN： 1550-4131  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： アミノ酸は細胞内シグナル伝達と生理学の既知の調節因子であるが,それらは細胞内で感知されるかは完全には理解されていない。ここでは,各アミノアシルt RNAシンテターゼ(ARS)は,その特異的基質蛋白質のリジンアミノアシル化(K AA)の形成を触媒することを通してそれの同種アミノ酸充足を感知することを報告する。生理的レベルでは,アミノ酸はそれらの基質に結合したARSを促進し,反応性アミノアシルアデニル酸を産生することによってそれらの基質におけるリジンのε-アミノ基上のK AAsを形成した。KAAマークはデアセチラーゼ,SIRT1とSIRT3などにより除去され,脱アセチル化に関与するものと同じ機構を用いることができる。これらの動的に制御されたK AAsはそれらのそれぞれのアミノ酸のシグナルを伝達する。ras関連GTP結合蛋白質A/Bへの可逆的leucylationはラパマイシン複合体1の哺乳類標的の活性を調節する。アポトーシスシグナル調節キナーゼ1のGlutaminylationはアポトーシスを抑制する。ARSの非標準的機能を発見され,系統的および機能的アミノ酸センシングとシグナル伝達ネットワークを明らかにした。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 哺乳類 ,  基質 ,  脱アセチル ,  複合体 ,  RNA【核酸】 ,  アミノアシル化 ,  合成酵素 ,  アポトーシス ,  タンパク質 ,  *アミノ酸 ,  脂肪族アミン ,  脂肪族カルボン酸 ,  第一アミン
準シソーラス用語： ASK1 ,  サーチュイン3 ,  デアセチラーゼ ,  細胞内シグナル伝達 , 【Automatic Indexing@JST】

著者キーワード (5件)： アミノ酸センシング ,  t RNAシンテターゼ ,  リジンアミノアシル化 ,  deacetylase ,  deaminoacylation

分類 (2件)： 酵素一般  (EB09010D) ,  細胞生理一般  (EF02010S)

物質索引 (1件)： リジン

タイトルに関連する用語 (3件)： リジン ,  センシング ,  アミノ酸シグナル