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J-GLOBAL ID：201802262997661556   整理番号：18A0493605

興奮性ニューラル集合は前頭前皮質における短期記憶をコードしている【Powered by NICT】

An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

著者 (30件)： Tian Yonglu (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Tian Yonglu (Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China) ,  Yang Chaojuan (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Cui Yaxuan (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Su Feng (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Su Feng (School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China) ,  Wang Yongjie (Center for Mitochondrial Biology and Medicine, and Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710049, China) ,  Wang Yongjie (Department of Physiology, Institute of Neuroscience and Collaborative Innovation Center for Brain Science, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China) ,  Wang Yangzhen (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Wang Yangzhen (School of Medicine, School of Life Sciences, Tsinghua University, Beijing 100084, China) ,  Yuan Peijiang (School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China) ,  Shang Shujiang (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Li Hao (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China) ,  Li Hao (China National Clinical Research Center for Neurological Diseases, Beijing 100050, China) ,  Zhao Jizong (Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China) ,  Zhao Jizong (China National Clinical Research Center for Neurological Diseases, Beijing 100050, China) ,  Zhu Desheng (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Tang Shiming (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China) ,  Cao Peng (State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, China) ,  Liu Yunbo (Institute of Laboratory Animal Science, Peking Union Medical College/Chinese Academy of Medical Science, Beijing 100021, China) ,  Wang Xunli (Laboratory Animal Center, Fujian University of Tradition Chinese Medicine, Fuzhou, Fujian Province 350122, China) ,  Wang Liecheng (Department of Physiology, Anhui Medical University, Hefei, Anhui Province 230032, China) ,  Zeng Wenbo (State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, CAS, Wuhan, Hubei Province 430071, China) ,  Jiang Haifei (State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, CAS, Wuhan, Hubei Province 430071, China) ,  Zhao Fei (State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, CAS, Wuhan, Hubei Province 430071, China) ,  Luo Minhua (State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, CAS, Wuhan, Hubei Province 430071, China) ,  Xiong Wei (School of Medicine, School of Life Sciences, Tsinghua University, Beijing 100084, China) ,  Qiu Zilong (CAS Key Laboratory of Primate Neurobiology, Institute of Neuroscience, CAS, Shanghai 200031, China) ,  Li Xiang-Yao (Department of Physiology, Institute of Neuroscience and Collaborative Innovation Center for Brain Science, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China) ,  Zhang Chen (State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China)
資料名： Cell Reports  (Cell Reports)
巻： 22  号： 7  ページ： 1734-1744  発行年： 2018年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 短期記憶(STM)は動物時間の短周期のための情報を保持するために重要である。神経振動と共に,持続性または再発性神経活動は,細胞レベルでのSTMをコードすることが知られている。しかし,回路レベルで符号化機構は謎のままである。ここでは,神経回路の活性を監視するための行動中のマウスに対する二光子イメージングを行った。STMのような行動パラダイムの基礎となる状況依存的に創発特性を示すことが内側前頭前野(mPFC)におけるニューロン亜集団を発見した。これらニューロン亜集団は興奮性ニューロンから成り,主に強い機能的結合を持つニューロンのグループを表している。超小型回路可塑性は分間維持され,Alzheimer病(AD)の動物モデルには存在しなかった。このように,これらの結果はSTMをコードする機能的に定義された神経細胞集合の創発的な振舞いに依存する機能的符号化機構を示した。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： Alzheimer病 ,  *前頭前野 ,  符号化 ,  ニューロン ,  塑性 ,  *興奮 ,  動物 ,  走査型トンネル顕微鏡
準シソーラス用語： 興奮性ニューロン ,  内側前頭前野 ,  創発 ,  二光子イメージング ,  神経活動 ,  神経 ,  *短期記憶 , 【Automatic Indexing@JST】

著者キーワード (4件)： 短期記憶 ,  前前頭皮質 ,  微小回路 ,  アルツハイマー病

分類 (1件)： 中枢神経系  (EJ12030F)

タイトルに関連する用語 (4件)： 興奮性 ,  集合 ,  前頭前皮質 ,  短期記憶