文献

J-GLOBAL ID：201802263978266983   整理番号：18A0115930

F344ラットにおける石英誘導肺炎に対する去痰薬である塩酸アンブロキソールの抑制効果

Suppressive effects of the expectorant drug ambroxol hydrochloride on quartz-induced lung inflammation in F344 rats

著者 (9件)： Kanie Shohei (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Kanie Shohei (Toxicology Laboratory, Discovery and Preclinical Research Division, TAIHO Pharmaceutical Co., Ltd., 224-2 Ebisuno, Hiraishi, Kawauchi-cho, Tokushima 771-0194, Japan) ,  Yokohira Masanao (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Yamakawa Keiko (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Nakano-Narusawa Yuko (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Yoshida Shota (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Yoshida Shota (Toxicology Laboratory, Discovery and Preclinical Research Division, TAIHO Pharmaceutical Co., Ltd., 224-2 Ebisuno, Hiraishi, Kawauchi-cho, Tokushima 771-0194, Japan) ,  Hashimoto Nozomi (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Imaida Katsumi (Onco-Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan)
資料名： Journal of Toxicologic Pathology (Web)  (Journal of Toxicologic Pathology (Web))
巻： 30  号： 2  ページ： 153-159(J-STAGE)  発行年： 2017年 
JST資料番号： U0779A  ISSN： 1881-915X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： サーファクタント蛋白質(SP)は呼吸器の構造と機能に必須であ...

シソーラス用語： *去痰薬 ,...
準シソーラス用語： F344ラット ,...

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著者キーワード (6件)： quartz ,  rat ,  lung inflammation ,  surfactant protein ,  ambroxol hydrochloride ,  instillation

分類 (2件)： 呼吸器の基礎医学  (GI01020H) ,  呼吸・呼吸器作用薬の基礎研究  (GW08010J)

物質索引 (1件)： 塩酸アンブロキソール

引用文献 (27件)：

• 1. Pérez-Gil J, and Keough KMW. Interfacial properties of surfactant proteins. Biochim Biophys Acta. 1408: 203-217. 1998.
• 2. Yokohira M, Yamakawa K, Nakano Y, Numano T, Furukawa F, Kishi S, Ninomiya F, Kanie S, Hitotsumachi H, Saoo K, and Imaida K. Immunohistochemical characteristics of surfactant proteins A, B, C and D in inflammatory and tumorigenic lung lesions of F344 rats. J Toxicol Pathol. 27: 175-182. 2014.
• 3. Perez-Gil J, and Weaver TE. Pulmonary surfactant pathophysiology: current models and open questions. Physiology (Bethesda). 25: 132-141. 2010.
• 4. Houtmeyers E, Gosselink R, Gayan-Ramirez G, and Decramer M. Effects of drugs on mucus clearance. Eur Respir J. 14: 452-467. 1999.
• 5. Nagahama F, Ito N, Momose T, Ogiwara M, Suetsugu S, Umeda H, Kawai M, Maekawa N, Inaba N, Oda Y, Uchihira F, Konishiike J, Sera Y, Ooka Y, Oishi M, Nakajima S, Sewake N, Mochizuki K, Kodomari N, Inoue K, Tsurutani H, and Nagano H. Efficacy and safety of long-term treatment with mucolytic agent (NA872) in chronic respiratory disease patients. Yakuri To Chiryo. 9: 2091-2104. 1981. (in Japanese)

タイトルに関連する用語 (7件)： F344ラット ,  石英 ,  誘導 ,  肺炎 ,  去痰薬 ,  塩酸アンブロキソール ,  抑制効果