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J-GLOBAL ID：201802275062513720   整理番号：18A0844434

Miro-1はGPCR活性化とCa2+ストレスによるミトコンドリア形状遷移を決定する【JST・京大機械翻訳】

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca²⁺ Stress

著者 (45件)： Nemani Neeharika (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Nemani Neeharika (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Carvalho Edmund (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Carvalho Edmund (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Tomar Dhanendra (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Tomar Dhanendra (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Dong Zhiwei (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Dong Zhiwei (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Ketschek Andrea (Department of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Breves Sarah L. (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Breves Sarah L. (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Jana Fabian (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Jana Fabian (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Worth Alison M. (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Worth Alison M. (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Heffler Julie (Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Palaniappan Palaniappan (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Palaniappan Palaniappan (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Tripathi Aparna (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Tripathi Aparna (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Subbiah Ramasamy (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Subbiah Ramasamy (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Riitano Massimo F. (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Riitano Massimo F. (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Seelam Ajay (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Seelam Ajay (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Manfred Thomas (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Manfred Thomas (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Itoh Kie (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA) ,  Meng Shuxia (Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA) ,  Sesaki Hiromi (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA) ,  Craigen William J. (Department of Molecular and Human Genetics, The Mitochondrial Diagnostic Laboratory, Baylor College of Medicine, Houston, TX 77030, USA) ,  Rajan Sudarsan (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Rajan Sudarsan (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Shanmughapriya Santhanam (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Shanmughapriya Santhanam (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Caplan Jeffrey (Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA) ,  Prosser Benjamin L. (Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Gill Donald L. (Department of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, PA 17033, USA) ,  Stathopulos Peter B. (Department of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada) ,  Gallo Gianluca (Department of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Chan David C. (Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA) ,  Mishra Prashant (Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA) ,  Madesh Muniswamy (Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA) ,  Madesh Muniswamy (Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA)
資料名： Cell Reports  (Cell Reports)
巻： 23  号： 4  ページ： 1005-1019  発行年： 2018年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： ミトコンドリア形状サイトゾルカルシウム([Ca2+]_c)過渡現象は,生物エネルギー学的出力の交換においてミトコンドリアCa2+([Ca2+]_m)を利用する。逆に,調節されない[Ca2+]_cは[Ca2+]_m過負荷を引き起こし,透過性遷移孔と細胞死を誘導する。MCU仲介Ca2+取り込みのアブレーションは[Ca2+]cの上昇を示し,ストレス誘発細胞死を防ぐことができなかった。これらの効果に対する機構は不明のままである。ここでは,ミトコンドリアがミトコンドリア分裂および膨潤と異なるサイトゾルCa2+誘導形状変化を生じることを報告する。[Ca2+]_c上昇は,MCU仲介Ca2+取り込みではなく,ミトコンドリア形状転移(ミスト)を示す過程に必須であると思われる。ミストは,複数の細胞型におけるEF-ハンドドメイン1を介してミトコンドリア蛋白質miro1により仲介される。さらに,miro1/KIF5B/チューブリン複合体のCa2+依存性破壊はmiro1 EF1ドメインにより決定される。機能的に,Miro1依存性ミストは,miro1 EF1変異体において減弱されるオートファジー/ミトファジーに必須である。このように,miro1は,ミストとして後生動物Ca2+シグナルを解読するサイトゾルCa2+センサである。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 複合体 ,  ミスト ,  *形態 ,  生物エネルギー ,  細胞死 ,  オートファジー ,  センサ ,  サイトゾル ,  膨潤 ,  過渡現象 ,  *ミトコンドリア
準シソーラス用語： マイトファジー ,  ミトコンドリア蛋白質 ,  形状変化 ,  ミトコンドリア分裂 , 【Automatic Indexing@JST】

著者キーワード (10件)： ミトコンドリアの形 ,  ミスト ,  カルシウム ,  MIRO ,  EFハンド ,  PTP ,  MCU ,  ミトファジー ,  オートファジー ,  ミトコンドリア動力学

分類 (1件)： 細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： GPCR ,  活性化 ,  ストレス ,  ミトコンドリア ,  遷移