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J-GLOBAL ID：201802275769963899   整理番号：18A0582854

安静状態脳波アルファリズムの機能的皮質源接続性はアルツハイマー病およびパーキンソン病に起因する軽度認知障害患者における類似の異常を示す【Powered by NICT】

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases

著者 (45件)： Babiloni Claudio (Department of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza”, Rome, Italy) ,  Babiloni Claudio (Institute for Research and Medical Care, IRCCS San Raffaele Pisana di Roma e di Cassino, Rome, Italy) ,  Del Percio Claudio (Department of Integrated Imaging, IRCCS SDN, Naples, Italy) ,  Lizio Roberta (Department of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza”, Rome, Italy) ,  Lizio Roberta (Institute for Research and Medical Care, IRCCS San Raffaele Pisana di Roma e di Cassino, Rome, Italy) ,  Noce Giuseppe (Department of Integrated Imaging, IRCCS SDN, Naples, Italy) ,  Lopez Susanna (Department of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza”, Rome, Italy) ,  Soricelli Andrea (Department of Integrated Imaging, IRCCS SDN, Naples, Italy) ,  Soricelli Andrea (Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy) ,  Ferri Raffaele (Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy) ,  Pascarelli Maria Teresa (Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy) ,  Catania Valentina (Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy) ,  Nobili Flavio (Clinical Neurology, Dept of Neuroscience (DiNOGMI), University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy) ,  Arnaldi Dario (Clinical Neurology, Dept of Neuroscience (DiNOGMI), University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy) ,  Fama Francesco (Clinical Neurology, Dept of Neuroscience (DiNOGMI), University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy) ,  Orzi Francesco (Department of Neuroscience, Mental Health and Sensory Organs, University of Rome “La Sapienza”, Rome, Italy) ,  Buttinelli Carla (Department of Neuroscience, Mental Health and Sensory Organs, University of Rome “La Sapienza”, Rome, Italy) ,  Giubilei Franco (Department of Neuroscience, Mental Health and Sensory Organs, University of Rome “La Sapienza”, Rome, Italy) ,  Bonanni Laura (Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d’Annunzio of Chieti-Pescara, Chieti, Italy) ,  Franciotti Raffaella (Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d’Annunzio of Chieti-Pescara, Chieti, Italy) ,  Onofrj Marco (Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d’Annunzio of Chieti-Pescara, Chieti, Italy) ,  Stirpe Paola (Institute for Research and Medical Care, IRCCS San Raffaele Pisana di Roma e di Cassino, Rome, Italy) ,  Fuhr Peter (Universitaetsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland) ,  Gschwandtner Ute (Universitaetsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland) ,  Ransmayr Gerhard (Department of Neurology 2, Med Campus III, Faculty of Medicine, Johannes Kepler University, Kepler University Hospital, Krankenhausstr. 9, A-4020 Linz, Austria) ,  Garn Heinrich (AIT Austrian Institute of Technology GmbH, Vienna, Austria) ,  Fraioli Lucia (Hospital San Raffaele of Cassino, Italy) ,  Pievani Michela (Laboratory of Alzheimer’s Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  D’Antonio Fabrizia (Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy) ,  De Lena Carlo (Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy) ,  Guentekin Bahar (Istanbul Medipol University, Istanbul, Turkey) ,  Hanoglu Lutfu (Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey) ,  Basar Erol (Department of Neurosciences, Dokuz Eyluel University, Izmir, Turkey) ,  Basar Erol (Department of Neurology, Dokuz Eyluel University Medical School, Izmir, Turkey) ,  Yener Gorsev (Department of Neurosciences, Dokuz Eyluel University, Izmir, Turkey) ,  Yener Gorsev (Department of Neurology, Dokuz Eyluel University Medical School, Izmir, Turkey) ,  Emek-Savas Derya Durusu (Department of Neurosciences, Dokuz Eyluel University, Izmir, Turkey) ,  Emek-Savas Derya Durusu (Department of Psychology, Dokuz Eyluel University, Izmir, Turkey) ,  Triggiani Antonio Ivano (Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy) ,  Taylor John Paul (Institute of Neuroscience, Newcastle University, Newcastle, UK) ,  De Pandis Maria Francesca (Hospital San Raffaele of Cassino, Italy) ,  Vacca Laura (Casa di Cura Privata del Policlinico (CCPP) Milano SpA, Milan, Italy) ,  Frisoni Giovanni B. (Laboratory of Alzheimer’s Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ,  Frisoni Giovanni B. (Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland) ,  Stocchi Fabrizio (Institute for Research and Medical Care, IRCCS San Raffaele Pisana di Roma e di Cassino, Rome, Italy)
資料名： Clinical Neurophysiology  (Clinical Neurophysiology)
巻： 129  号： 4  ページ： 766-782  発行年： 2018年 
JST資料番号： A1155A  ISSN： 1388-2457  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 本研究では,休止状態閉眼脳波(rsEEG)リズムの機能的皮質源連結性のマーカーは,健常高齢者(Nold)と比較してAlzheimer病(ADMCI)とParkinson病(PDMCI)疾患による軽度認知障害を有する被験者における異常である可能性があるという仮説を試験した。rsEEGデータはADMCI,PDMCI,Nold被験者(群75)で収集した。rsEEG皮質源からeLORETAフリーウェア推定機能的遅れ線形連結性(LLC)。受信者動作特性(AUROC)曲線下面積はNoldとMCI個体の分類精度を示した。後大脳半球間と広範な半球内アルファLLC溶液はNold群と比較して,MCI群で異常に低かった。個体レベルでは,後部アルファ線源におけるLLC溶液のAUROC曲線はNold対ADMCI PDMCI個体の識別における中程度の精度(0.70 0.72)を示した。LLC解の差は二MCI群間で認められなかった。これらの知見は,ADMCIとPDMCIにおける広範なα線源の推定機能的皮質結合性の類似した異常を明らかにした。群と個体レベルの両方で真実である。ADMCIとPDMCI被験者におけるアルファ線源類似する結合性の異常は,一般的なコリン作動性障害を反映するかもしれない。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *Alzheimer病 ,  *皮質 ,  *Parkinson病 ,  *患者 ,  *安静 ,  *連結性 ,  *脳波 ,  大脳半球 ,  脂肪族アミン ,  脂肪族アルコール ,  第四アンモニウム ,  アミノアルコール
準シソーラス用語： 分類精度 ,  被験者 ,  健常高齢者 ,  *リズム ,  閉眼 ,  *軽度認知障害 , 【Automatic Indexing@JST】

著者キーワード (4件)： 機能的脳接続性 ,  安静状態EEGリズム ,  アルツハイマー病(ADMCI)に起因する軽度認知障害 ,  パーキンソン病(PDMCI)に起因する軽度認知障害

分類 (2件)： 神経系の疾患  (GN03000O) ,  神経系の診断  (GN02000H)

物質索引 (1件)： コリン

タイトルに関連する用語 (11件)： 安静 ,  脳波 ,  リズム ,  皮質 ,  接続性 ,  アルツハイマー病 ,  パーキンソン病 ,  起因 ,  軽度認知障害 ,  患者 ,  類似