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J-GLOBAL ID：201802278485903336   整理番号：18A0939314

シナプトタグミン4はインシュリン分泌小胞のCa2+感受性を調節することにより膵臓β細胞成熟を調節する【JST・京大機械翻訳】

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca²⁺ Sensitivity of Insulin Secretion Vesicles

著者 (34件)： Huang Chen (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Huang Chen (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Huang Chen (The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Walker Emily M. (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Dadi Prasanna K. (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Hu Ruiying (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Hu Ruiying (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Hu Ruiying (The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Xu Yanwen (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Xu Yanwen (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Xu Yanwen (The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Zhang Wenjian (China-Japan Friendship Hospital, Beijing 100029, P. R. China) ,  Sanavia Tiziana (Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA) ,  Mun Jisoo (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Liu Jennifer (Diabetes Center, UCSF, San Francisco, CA 94143, USA) ,  Nair Gopika G. (Diabetes Center, UCSF, San Francisco, CA 94143, USA) ,  Tan Hwee Yim Angeline (Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, Singapore) ,  Wang Sui (Department of Ophthalmology, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA 94304, USA) ,  Magnuson Mark A. (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Magnuson Mark A. (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Magnuson Mark A. (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Stoeckert Christian J. (Institute for Biomedical Informatics and Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA) ,  Hebrok Matthias (Diabetes Center, UCSF, San Francisco, CA 94143, USA) ,  Gannon Maureen (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gannon Maureen (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gannon Maureen (The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gannon Maureen (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gannon Maureen (Department of Medicine, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Han Weiping (Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, Singapore) ,  Stein Roland (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Jacobson David A. (Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gu Guoqiang (Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gu Guoqiang (Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA) ,  Gu Guoqiang (The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA)
資料名： Developmental Cell  (Developmental Cell)
巻： 45  号： 3  ページ： 347-361.e5  発行年： 2018年 
JST資料番号： W1692A  ISSN： 1534-5807  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 新生ほ乳動物の島β細胞は,高い基礎インシュリン分泌と低グルコース刺激インシュリン分泌(GSIS)を示す。ここでは,新生児のβ細胞が類似の細胞内Ca2+濃度に反応して成体より多くのインシュリンを分泌することを示し,インシュリン分泌のCa2+感受性の違いを示唆した。β細胞Ca2+センサSyt7の非Ca2+結合パラログであるシナプトタグミン4(Syt4)はβ細胞成熟時に約8倍増加した。Syt4アブレーションは基礎インシュリン分泌を増加させ,GSISを低下させた。早熟なSyt4発現は,基礎インシュリン分泌を抑制したが,膵島形態形成とGSISを障害した。Syt4はインシュリン顆粒に局在し,Syt4レベルは容易に放出可能な小胞の数に逆に関連した。このように,Syt4の転写調節はインシュリン分泌に影響する;Syt4発現はMYT転写因子により部分的に調節され,Syt4転写を抑制する。最後に,ヒトSyt4は,ヒトβ細胞系,EndoC-βH1細胞においてGSISを調節した。これらの知見は,Ca2+感知の変化がβ細胞成熟の調節に果たす役割を明らかにした。Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *分泌 ,  ヒト ,  糖尿病 ,  新生児 ,  顆粒 ,  Langerhans島 ,  形態形成 ,  哺乳類 ,  転写因子 ,  *インスリン ,  センサ ,  *分泌顆粒
準シソーラス用語： *インスリン分泌 ,  *シナプトタグミン , 【Automatic Indexing@JST】

著者キーワード (10件)： MYT1 ,  SYT4 ,  成熟 ,  インスリン ,  糖尿病 ,  Ca2+ ,  分泌 ,  ベシクル ,  ドッキング ,  膜融合

分類 (2件)： 生物学的機能  (EB03040U) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (7件)： シナプトタグミン ,  インシュリン ,  分泌小胞 ,  Ca2+感受性 ,  調節 ,  膵臓β細胞 ,  成熟